Tuberculosis and lung cancer: metabolic pathways play a key role.

IF 1.1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Nucleosides, Nucleotides & Nucleic Acids Pub Date : 2024-02-02 DOI:10.1080/15257770.2024.2308522
Kianoosh Ferdosnejad, Mohammad Saber Zamani, Erfan Soroush, Abolfazl Fateh, Seyed Davar Siadat, Samira Tarashi
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Abstract

Despite the fact that some cases of tuberculosis (TB) are undiagnosed and untreated, it remains a serious global public health issue. In the diagnosis, treatment, and control of latent and active TB, there may be a lack of effectiveness. An understanding of metabolic pathways can be fundamental to treat latent TB infection and active TB disease. Rather than targeting Mycobacterium tuberculosis, the control strategies aim to strengthen host responses to infection and reduce chronic inflammation by effectively enhancing host resistance to infection. The pathogenesis and progression of TB are linked to several metabolites and metabolic pathways, and they are potential targets for host-directed therapies. Additionally, metabolic pathways can contribute to the progression of lung cancer in patients with latent or active TB. A comprehensive metabolic pathway analysis is conducted to highlight lung cancer development in latent and active TB. The current study aimed to emphasize the association between metabolic pathways of tumor development in patients with latent and active TB. Health control programs around the world are compromised by TB and lung cancer due to their special epidemiological and clinical characteristics. Therefore, presenting the importance of lung cancer progression through metabolic pathways occurring upon TB infection can open new doors to improving control of TB infection and active TB disease while stressing that further evaluations are required to uncover this correlation.

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肺结核与肺癌:代谢途径发挥着关键作用。
尽管有些结核病病例未经诊断和治疗,但它仍然是一个严重的全球公共卫生问题。在诊断、治疗和控制潜伏和活动性结核病方面,可能缺乏有效性。了解代谢途径是治疗潜伏肺结核感染和活动性肺结核病的基础。控制策略的目标不是针对结核分枝杆菌,而是通过有效增强宿主对感染的抵抗力,加强宿主对感染的反应,减少慢性炎症。结核病的发病机制和进展与多种代谢物和代谢途径有关,它们是宿主定向疗法的潜在靶点。此外,代谢途径还可能导致潜伏或活动性肺结核患者肺癌的进展。进行全面的代谢途径分析可突出潜伏期和活动期肺结核患者的肺癌发展。本研究旨在强调潜伏肺结核和活动性肺结核患者肿瘤发生的代谢途径之间的关联。由于肺结核和肺癌在流行病学和临床上的特殊性,全世界的健康控制计划都受到了它们的影响。因此,介绍肺结核感染后通过代谢途径导致肺癌进展的重要性,可以为改善肺结核感染和活动性肺结核病的控制打开新的大门,同时强调需要进一步评估以揭示这种相关性。
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来源期刊
Nucleosides, Nucleotides & Nucleic Acids
Nucleosides, Nucleotides & Nucleic Acids 生物-生化与分子生物学
CiteScore
2.60
自引率
7.70%
发文量
91
审稿时长
6 months
期刊介绍: Nucleosides, Nucleotides & Nucleic Acids publishes research articles, short notices, and concise, critical reviews of related topics that focus on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. Complete with experimental details, this all-inclusive journal emphasizes the synthesis, biological activities, new and improved synthetic methods, and significant observations related to new compounds.
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