Allelic variants of the estrogen receptor genes and frailty phenotype in postmenopausal women.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-06 DOI:10.1080/13697137.2024.2306269

A Monllor-Tormos, A García-Vigara, O Morgan, M-Á García-Pérez, J J Tarín, A Cano

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Abstract

Objective: The prevalence of frailty has been related to menopause. Our main objective was to investigate whether single nucleotide polymorphisms (SNPs) of the estrogen receptor (ER) ER $α$ and ER $β$ genes were related to the frailty phenotype in a population of community-dwelling postmenopausal women.

Methods: A cross-sectional study was performed in which we selected five SNPs, three in the ER $α$ gene and two in the ER $β$ . Linear regression was used to estimate the percentage of phenotypic variance after adjusting for confounding variables.

Results: A total of 470 women (mean ± standard deviation age 63.83 ± 8.16 years) were included, of whom 137 women were frail. The SNP rs3798577 of the ER $α$ gene was the only variant associated with frailty, but this significance faded in the multivariant analysis. Body mass index (p = 0.012), number of comorbidities (0 vs. ≥2, p = 0.002) and two reproductive variables, number of miscarriages (none vs. ≥2, p = 0.036) and of childbirths (one vs. ≥3, p = 0.008), were independently related to frailty.

Conclusion: The five SNPs of the ER $α$ and ER $β$ genes tested were not correlated with frailty. Other SNPs of the ER warrant analysis to clarify whether variance in the gene response affects frailty status.

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雌激素受体基因的等位基因变异与绝经后妇女的虚弱表型。

目的虚弱的发生率与更年期有关。我们的主要目的是研究雌激素受体（ER）ERα和ERβ基因的单核苷酸多态性（SNPs）是否与社区绝经后妇女人群的虚弱表型有关：我们进行了一项横断面研究，选取了五个 SNPs，其中三个在 ERα 基因中，两个在 ERβ 基因中。在对混杂变量进行调整后，我们使用线性回归法估算了表型变异的百分比：共纳入 470 名妇女（平均 ± 标准差年龄为 63.83 ± 8.16 岁），其中 137 名妇女体弱。ERα基因的 SNP rs3798577 是唯一一个与体弱有关的变异，但在多变量分析中这一意义消失了。体重指数（p = 0.012）、合并症数量（0 vs. ≥2，p = 0.002）和两个生殖变量--流产次数（无 vs. ≥2，p = 0.036）和分娩次数（1 vs. ≥3，p = 0.008）--与虚弱有独立关系：结论：ERα和ERβ基因的5个SNP与体弱无关。结论：ERα和ERβ基因的5个SNPs与体弱无关，需要对ER的其他SNPs进行分析，以明确基因反应的差异是否会影响体弱状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.