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Rebalancing the narrative on MHT - the menopause momentum continues following FDA 'unboxing'! 重新平衡MHT的叙述-绝经势头在FDA“开箱”后继续!
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-06 DOI: 10.1080/13697137.2026.2620977
Rossella E Nappi, Seng Bing Ang, Steven R Goldstein, Pauline Maki, Nick Panay, Wendy Wolfman
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引用次数: 0
A preliminary pilot study to address design issues related to research on potential association of hormone therapy and adhesive capsulitis. 一项初步的试点研究,旨在解决与激素治疗和粘连性囊炎的潜在关联研究相关的设计问题。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-30 DOI: 10.1080/13697137.2026.2615391
Emily K Reinke, Anne C Ford, Elizabeth Wahl, June Kennedy, Emily Poehlein, Cynthia L Green, Eliana Saltzman, Jocelyn R Wittstein

Objective: Adhesive capsulitis (AC) is considered idiopathic, yet typically affects women aged 40-60 years. The purpose of this study was to determine whether hormone therapy is protective against AC in menopausal women. The study hypothesized that patients prescribed hormone therapy would have lower odds of AC than those not using hormone therapy.

Method: Medical record extraction for a single health maintenance organization was used to identify postmenopausal women aged 40- 60 years and assess the utilization of hormone therapy and diagnosis of AC. The distribution of AC and endocrine disorders was compared between treatment groups using chi-squared tests and the odds ratio (OR) was reported.

Results: The cohort included 1952 patients (152 hormone therapy, 1800 without hormone therapy). No statistically significant differences were found between treatment groups for endocrine disorders. A higher percentage of AC was noted in patients without hormone therapy compared to patients with hormone therapy (7.65% vs. 3.95%), although the association was not statistically significant (OR 1.99; 95% confidence interval 0.86-4.58; p = 0.10).

Conclusion: This pilot study did not demonstrate a statistically significant difference in odds of AC in menopausal women with and without hormone therapy. Larger prospective studies are needed to further explore potential protective effects of hormone therapy against AC.

目的:粘连性囊炎(AC)被认为是特发性的,但通常影响40-60岁的女性。本研究的目的是确定激素治疗是否对绝经期妇女的AC有保护作用。该研究假设,接受激素治疗的患者比不接受激素治疗的患者患AC的几率更低。方法:抽取某健康维护机构的病历,对40 ~ 60岁绝经后妇女进行诊断,评估激素治疗的使用情况和AC的诊断情况。采用卡方检验比较两组间AC和内分泌疾病的分布情况,并报道比值比(OR)。结果:纳入1952例患者(激素治疗152例,未激素治疗1800例)。内分泌紊乱治疗组间差异无统计学意义。与接受激素治疗的患者相比,未接受激素治疗的患者AC百分比更高(7.65% vs. 3.95%),尽管两者之间的关联无统计学意义(OR 1.99; 95%可信区间0.86-4.58;p = 0.10)。结论:这项初步研究没有显示绝经期妇女接受和不接受激素治疗的AC发生率有统计学上的显著差异。需要更大规模的前瞻性研究来进一步探索激素治疗对AC的潜在保护作用。
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引用次数: 0
Association between adverse life events, DNA methylation and risk of premature ovarian insufficiency. 不良生活事件、DNA甲基化与卵巢功能不全风险之间的关系。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-28 DOI: 10.1080/13697137.2025.2610484
Shuang Yuan, Liutong Wei, Junyan Sun, Yihui Fan, Meiling Li, Lulu Wang, Qiuwan Zhang, Qian Wang, Shengju Yin, Dongmei Lai

Objective: This study aimed to assess psychological and lifestyle risk factors for premature ovarian insufficiency (POI) and their association with DNA methylation.

Methods: A case-control study was conducted in Shanghai (2017-2022), including 304 controls and 160 newly diagnosed cases with POI (diagnosed within the past 6 months). Cumulative adverse life events were assessed using the life event scale (LES), and genome-wide DNA methylation was evaluated in whole blood-derived DNA obtained from a sub-sample.

Results: The median total event score for POI patients and control individuals was 48.5 and 20.0, respectively (p < 0.001). Participants experiencing more stressful life events (LES >32) were 2.33-fold more likely to have POI compared to controls (odds ratio 2.33, 95% confidence interval 1.53-3.56). Genome-wide DNA methylation analysis identified 5582 differentially methylated sites (DMSs) between POI patients and controls. Further analysis showed that higher negative life events scores were significantly associated with accelerated DNA methylation aging in the POI group (β = 0.06, p < 0.001).

Conclusion: This case-control study revealed that cumulative stressful or adverse life events were associated with an increased risk of POI, and that accelerated epigenetic aging was correlated with chronic stress in POI patients. These findings suggest potential links that warrant further mechanistic investigation.

目的:本研究旨在评估卵巢早衰(POI)的心理和生活方式危险因素及其与DNA甲基化的关系。方法:在上海市(2017-2022年)开展病例-对照研究,包括304例对照和160例新诊断POI(最近6个月内诊断)。使用生活事件量表(LES)评估累积不良生活事件,并对从亚样本中获得的全血来源DNA进行全基因组DNA甲基化评估。结果:POI患者和对照组的中位总事件评分分别为48.5和20.0 (p 32),发生POI的可能性是对照组的2.33倍(优势比2.33,95%可信区间1.53-3.56)。全基因组DNA甲基化分析在POI患者和对照组之间鉴定出5582个差异甲基化位点(dms)。进一步分析表明,较高的负性生活事件评分与POI组DNA甲基化老化加速显著相关(β = 0.06, p)。结论:本病例对照研究显示,累积应激或不良生活事件与POI患者POI风险增加相关,加速表观遗传老化与POI患者慢性应激相关。这些发现表明了潜在的联系,需要进一步的机制调查。
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引用次数: 0
Global burden of gastroesophageal reflux disease in women of perimenopausal age: trends and forecasts. 围绝经期妇女胃食管反流疾病的全球负担:趋势和预测。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-26 DOI: 10.1080/13697137.2025.2610483
Yijun Zheng, Haoen Li, Yitong Zheng, Yanping Wu, Yujie Wen, Jiaxuan Zhou, Jia Wei, Wenting Zhang, Tong Kang, Bin Qin, Jiong Jiang, Jun Zhang, Yan Cheng

Objective: Gastroesophageal reflux disease (GERD) is a highly prevalent disorder that diminishes quality of life. Hormonal fluctuations during the perimenopausal transition (age 45-54 years) may heighten susceptibility to GERD, yet the magnitude of the burden in this group remains poorly characterized. This study aims to quantify GERD trends in women of perimenopausal age and forecast disease trajectories to 2045.

Method: Data from the 2021 Global Burden of Disease (GBD) database were utilized. Age-standardized rates were calculated, annual percentage changes were estimated (EAPC) and Bayesian age-period-cohort (BAPC) models were employed to project trends to 2045.

Results: From 1990 to 2021, the global age-standardized prevalence rate (ASPR) and age-standardized disability-adjusted life year rate (ASDR) of GERD in women of perimenopausal age exhibited a decreasing trend (EAPC for both: -0.09, 95% confidence interval [CI] - 0.14 to -0.04), despite a marked rise in the prevalent cases. Latin America recorded the highest ASDR. Middle Socio-demographic Index regions experienced the greatest growth in prevalent cases. The BAPC model predicts a rise in the age-standardized incidence rate.

Conclusion: The burden of GERD in women of perimenopausal age exhibits significant global heterogeneity. Incidence rates have risen persistently and are projected to increase through 2045.

目的:胃食管反流病(GERD)是一种非常普遍的疾病,降低了生活质量。围绝经期过渡期间(45-54岁)的激素波动可能会增加对胃食管反流的易感性,但这一群体的负担程度仍不清楚。本研究旨在量化围绝经期妇女的GERD趋势,并预测到2045年的疾病轨迹。方法:使用2021年全球疾病负担(GBD)数据库的数据。计算了年龄标准化率,估计了年百分比变化(EAPC),并采用贝叶斯年龄-时期-队列(BAPC)模型预测了到2045年的趋势。结果:从1990年到2021年,围绝经期妇女GERD的全球年龄标准化患病率(ASPR)和年龄标准化残疾调整生命年率(ASDR)呈下降趋势(两者的EAPC均为-0.09,95%置信区间[CI] - 0.14至-0.04),尽管患病率明显上升。拉丁美洲的ASDR最高。中等社会人口指数区域的流行病例增长最大。BAPC模型预测了年龄标准化发病率的上升。结论:围绝经期妇女的胃食管反流负担具有明显的全球异质性。发病率持续上升,预计到2045年还会增加。
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引用次数: 0
Statement of Retraction: Rapid and random-start endometrial preparation before outpatient hysteroscopic polypectomy in patients of perimenopausal age. 收缩声明:围绝经期患者在门诊宫腔镜息肉切除术前快速和随机启动子宫内膜准备。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-20 DOI: 10.1080/13697137.2026.2618911
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引用次数: 0
Intermittent walking training improves thyroid function and cardiometabolic risk factors in postmenopausal women. 间歇性步行训练可改善绝经后妇女的甲状腺功能和心脏代谢危险因素。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-08 DOI: 10.1080/13697137.2025.2601008
Wissal Abassi, Nejmeddine Ouerghi, Nidhal Jebabli, Wissem Dhahbi, Nadhir Hammami, Noomen Guelmami, Anissa Bouassida, Moncef Feki, Katja Weiss, Thomas Rosemann, Ismail Dergaa, Beat Knechtle

Objective: This study aimed to investigate the impact of a 10-week moderate intermittent walking training (MIWT) program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women.

Methods: Thirty-six obese postmenopausal women (body mass index ≥ 30 kg.m-2, aged 50-60 years) were randomized to either the MIWT group (n = 18) or the control group (CG; n = 18). Participants performed the MIWT program for four sessions per week (five repetitions of the 6-min walking test [6MWT] at 60-80% of the distance covered in the 6-min walking test [6MWD], interspersed by 6 min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone [TSH] and thyroxine-free [FT4]), lipid profile (triglycerides [TRG], total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C] and low-density lipoprotein cholesterol [LDL-C]), blood pressure and aerobic fitness (6MWT) were determined before and after the MIWT.

Results: The MIWT resulted in significant reductions in body composition (p < 0.05), TSH (-5.29%, p = 0.019, d = 0.16), FT4 (-1.84%, p = 0.032, d = 0.28), TRG (-7.29%, p = 0.003, d = 0.27), TC (-4.98%, p = 0.003, d = 0.31), LDL-C (-10.08%, p = 0.003, d = 0.51) and SBP (-2.57%, p = 0.035, d = 0.66), and significant increases in HDL-C (13.36%, p = 0.020, d = 0.52) and 6MWD (2.81%, p = 0.031, d = 0.51).

Conclusions: A 10-week MIWT program modestly improved thyroid hormones, cardiometabolic risk and functional capacity in obese postmenopausal women without adverse effects. MIWT is an accessible and low-impact intervention suitable for integration into routine clinical practice to prevent and manage thyroid-related and cardiometabolic disorders in this high-risk population.

目的:本研究旨在探讨10周中度间歇步行训练(MIWT)计划对肥胖绝经后妇女甲状腺激素水平和关键心脏代谢指标的影响。方法:36例肥胖绝经后妇女(体重指数≥30 kg)。m-2,年龄50-60岁)随机分为MIWT组(n = 18)和对照组(CG; n = 18)。参与者每周进行四次MIWT训练(重复5次6分钟步行测试[6MWT],每次步行距离为6分钟步行测试[6MWD]所走距离的60-80%,在重复之间穿插6分钟的主动恢复)。在MIWT前后测定体成分、甲状腺激素(促甲状腺激素[TSH]和无甲状腺激素[FT4])、血脂(甘油三酯[TRG]、总胆固醇[TC]、高密度脂蛋白胆固醇[HDL-C]和低密度脂蛋白胆固醇[LDL-C])、血压和有氧适能(6MWT)。结果:MIWT导致身体成分显著减少(p p = 0.019 d = 0.16), FT4 (-1.84%, p = 0.032 d = 0.28),丹(-7.29%,p = 0.003 d = 0.27), TC (-4.98%, p = 0.003 d = 0.31),低密度脂蛋白(-10.08%,p = 0.003 d = 0.51)和SBP (-2.57%, p = 0.035 d = 0.66),并显著增加高密度脂蛋白胆固醇(13.36%,p = 0.020 d = 0.52)和6随钻测量(2.81%,p = 0.031 d = 0.51)。结论:10周的MIWT计划适度改善了肥胖绝经后妇女的甲状腺激素、心脏代谢风险和功能能力,无不良反应。MIWT是一种易于获得的低影响干预措施,适合纳入常规临床实践,以预防和管理这一高危人群的甲状腺相关疾病和心脏代谢疾病。
{"title":"Intermittent walking training improves thyroid function and cardiometabolic risk factors in postmenopausal women.","authors":"Wissal Abassi, Nejmeddine Ouerghi, Nidhal Jebabli, Wissem Dhahbi, Nadhir Hammami, Noomen Guelmami, Anissa Bouassida, Moncef Feki, Katja Weiss, Thomas Rosemann, Ismail Dergaa, Beat Knechtle","doi":"10.1080/13697137.2025.2601008","DOIUrl":"https://doi.org/10.1080/13697137.2025.2601008","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the impact of a 10-week moderate intermittent walking training (MIWT) program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women.</p><p><strong>Methods: </strong>Thirty-six obese postmenopausal women (body mass index ≥ 30 kg.m<sup>-2</sup>, aged 50-60 years) were randomized to either the MIWT group (<i>n</i> = 18) or the control group (CG; <i>n</i> = 18). Participants performed the MIWT program for four sessions per week (five repetitions of the 6-min walking test [6MWT] at 60-80% of the distance covered in the 6-min walking test [6MWD], interspersed by 6 min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone [TSH] and thyroxine-free [FT4]), lipid profile (triglycerides [TRG], total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C] and low-density lipoprotein cholesterol [LDL-C]), blood pressure and aerobic fitness (6MWT) were determined before and after the MIWT.</p><p><strong>Results: </strong>The MIWT resulted in significant reductions in body composition (<i>p</i> < 0.05), TSH (-5.29%, <i>p</i> = 0.019, <i>d</i> = 0.16), FT4 (-1.84%, <i>p</i> = 0.032, <i>d</i> = 0.28), TRG (-7.29%, <i>p</i> = 0.003, <i>d</i> = 0.27), TC (-4.98%, <i>p</i> = 0.003, <i>d</i> = 0.31), LDL-C (-10.08%, <i>p</i> = 0.003, <i>d</i> = 0.51) and SBP (-2.57%, <i>p</i> = 0.035, <i>d</i> = 0.66), and significant increases in HDL-C (13.36%, <i>p</i> = 0.020, <i>d</i> = 0.52) and 6MWD (2.81%, <i>p</i> = 0.031, <i>d</i> = 0.51).</p><p><strong>Conclusions: </strong>A 10-week MIWT program modestly improved thyroid hormones, cardiometabolic risk and functional capacity in obese postmenopausal women without adverse effects. MIWT is an accessible and low-impact intervention suitable for integration into routine clinical practice to prevent and manage thyroid-related and cardiometabolic disorders in this high-risk population.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body composition and self-perception of age and health in resistance-trained postmenopausal women. 经抗阻训练的绝经后妇女的身体组成和年龄与健康的自我认知。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-08 DOI: 10.1080/13697137.2025.2601006
Alberto Nishimura, Milton Rocha Moraes, Elbert Wander Cantão, Patrício Lopes Araújo Leite, Larissa Alves Maciel, Caio Victor Sousa, Rita Cristine Barboza Patricio, Samuel da Silva Aguiar, Carmen Sílvia Grubert Campbell, Hélcio Rossi Gonçalves, Herbert Gustavo Simões

Objective: This study investigated the associations among subjective age, age perception ratio (APR), self-rated health, happiness score and body composition in postmenopausal women.

Method: A total of 46 postmenopausal women aged 50-69 years participated, divided into a resistance training group (RTG; n = 24; age 58.2 ± 5.1 years, ≥7 years training) and an untrained group (UNG; n = 22; age 58.5 ± 4.1 years). The APR, self-rated health and happiness were assessed and compared. Body composition variables included the waist-to-hip ratio, waist-to-height ratio, body fat percentage and absolute fat mass. Statistical analyses included t-tests, correlations and multiple regression to predict APR.

Results: Women in the RTG perceived themselves as 27.1 ± 11.3% younger than their actual age, significantly more than the 10.6 ± 17.8% in the UNG (p = 0.001). Self-rated health was higher in the RTG (4.1 ± 0.7) than in the UNG (3.1 ± 1.0; p < 0.001), with no group differences in happiness (p = 0.799). The APR correlated with self-rated health (r = 0.689; p < 0.001) and happiness (r = 0.435; p = 0.003). Regression showed that self-rated health, happiness and waist-to-hip ratio predicted 56.7% of APR variance (R2 = 0.567; p < 0.001). The RTG also had better body composition values than the UNG.

Conclusion: Postmenopausal women engaged in long-term resistance training showed a higher APR and self-rated health, likely associated with improved body composition and younger self-perception of age.

目的:探讨绝经后妇女主观年龄、年龄感知比(APR)、自评健康、幸福指数与身体成分的关系。方法:50 ~ 69岁绝经后妇女46例,分为阻力训练组(RTG, n = 24,年龄58.2±5.1岁,训练≥7年)和未训练组(UNG, n = 22,年龄58.5±4.1岁)。评估和比较了APR,自我评价的健康和幸福。身体组成变量包括腰臀比、腰高比、体脂率和绝对脂肪量。结果:RTG组的女性认为自己比实际年龄年轻27.1±11.3%,显著高于UNG组的10.6±17.8% (p = 0.001)。RTG组自评健康水平(4.1±0.7)高于UNG组(3.1±1.0;p p = 0.799)。APR与自评健康相关(r = 0.689; p r = 0.435; p = 0.003)。回归显示,自评健康、快乐和腰臀比预测APR方差的56.7% (R2 = 0.567; p)结论:长期抗阻训练的绝经后妇女APR和自评健康较高,可能与改善的身体成分和更年轻的年龄自我感知有关。
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引用次数: 0
Sexual dysfunction and quality of life in postmenopausal type 2 diabetes mellitus: clinical and laboratory factors. 绝经后2型糖尿病患者的性功能障碍和生活质量:临床和实验室因素。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-08 DOI: 10.1080/13697137.2025.2601007
Sandra Ester Alves, Márcia Silva Queiroz

Objective: This study aimed to evaluate female sexual dysfunction (FSD) in postmenopausal women with and without type 2 diabetes (T2D) and its relationship with clinical, laboratory and socioeconomic parameters and quality of life (QoL).

Method: This cross-sectional study enrolled postmenopausal women with and without T2D not taking hormone replacement. Clinical and laboratory factors were assessed, and participants answered cardiovascular risk, socioeconomic, Short Form Health Survey 36 (SF-36) and Female Sexual Function Index (FSFI) questionnaires.

Results: Postmenopausal women without diabetes (n = 105) and with a previous T2D diagnosis (n = 110) were similar in age, marital status, race/ethnicity, employment status, alcohol use and body mass index. Women with T2D showed higher glycemia, glycated hemoglobin, cholesterol, thyroid-stimulating hormone and cardiovascular risk factors. SF-36 scores were significantly lower in women with T2D and sexual dysfunction compared to those without diabetes. FSFI scores below 26.55 were associated with higher odds of FSD with increasing age, whereas vitality showed an inverse association.

Conclusion: In postmenopausal women with T2D, reduced FSFI scores along with hypertension, hypothyroidism and elevated cardiometabolic risk were linked to poorer QoL. Age increased the odds of FSD, while vitality decreased them. These results underscore the multifactorial interaction of T2D, comorbidities and menopause in women's sexual health and well-being.

目的:探讨绝经后伴有和不伴有2型糖尿病(T2D)的女性性功能障碍(FSD)及其与临床、实验室、社会经济参数和生活质量(QoL)的关系。方法:这项横断面研究纳入了绝经后未接受激素替代治疗的有或无T2D的妇女。对临床和实验室因素进行评估,参与者回答心血管风险、社会经济、简短健康调查36 (SF-36)和女性性功能指数(FSFI)问卷。结果:无糖尿病的绝经后妇女(n = 105)和既往T2D诊断的妇女(n = 110)在年龄、婚姻状况、种族/民族、就业状况、酒精使用和体重指数方面相似。患有T2D的女性血糖、糖化血红蛋白、胆固醇、促甲状腺激素和心血管危险因素均较高。与没有糖尿病的女性相比,患有T2D和性功能障碍的女性的SF-36评分明显较低。FSFI得分低于26.55与FSD的几率随年龄增长而增加相关,而活力呈负相关。结论:绝经后T2D患者,FSFI评分降低、高血压、甲状腺功能减退和心脏代谢风险升高与较差的生活质量有关。年龄增加了FSD的几率,而活力降低了FSD的几率。这些结果强调了T2D、合并症和绝经对女性性健康和福祉的多因素相互作用。
{"title":"Sexual dysfunction and quality of life in postmenopausal type 2 diabetes mellitus: clinical and laboratory factors.","authors":"Sandra Ester Alves, Márcia Silva Queiroz","doi":"10.1080/13697137.2025.2601007","DOIUrl":"https://doi.org/10.1080/13697137.2025.2601007","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate female sexual dysfunction (FSD) in postmenopausal women with and without type 2 diabetes (T2D) and its relationship with clinical, laboratory and socioeconomic parameters and quality of life (QoL).</p><p><strong>Method: </strong>This cross-sectional study enrolled postmenopausal women with and without T2D not taking hormone replacement. Clinical and laboratory factors were assessed, and participants answered cardiovascular risk, socioeconomic, Short Form Health Survey 36 (SF-36) and Female Sexual Function Index (FSFI) questionnaires.</p><p><strong>Results: </strong>Postmenopausal women without diabetes (<i>n</i> = 105) and with a previous T2D diagnosis (<i>n</i> = 110) were similar in age, marital status, race/ethnicity, employment status, alcohol use and body mass index. Women with T2D showed higher glycemia, glycated hemoglobin, cholesterol, thyroid-stimulating hormone and cardiovascular risk factors. SF-36 scores were significantly lower in women with T2D and sexual dysfunction compared to those without diabetes. FSFI scores below 26.55 were associated with higher odds of FSD with increasing age, whereas vitality showed an inverse association.</p><p><strong>Conclusion: </strong>In postmenopausal women with T2D, reduced FSFI scores along with hypertension, hypothyroidism and elevated cardiometabolic risk were linked to poorer QoL. Age increased the odds of FSD, while vitality decreased them. These results underscore the multifactorial interaction of T2D, comorbidities and menopause in women's sexual health and well-being.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Menopausal transition and metabolic syndrome risk: insights from the Chinese PALM longitudinal cohort. 绝经过渡和代谢综合征风险:来自中国PALM纵向队列的见解。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-08 DOI: 10.1080/13697137.2025.2591300
Jingbo Huang, Penghui Feng, Ruiyi Tang, Feiling Huang, Yubo Fan, Xuanjin Yang, Zhuolin Xie, Lingjin Yang, Xiaonan Ma, Keyang Yang, Runhua Zhang, Gaifen Liu, Min Luo, Rong Chen

Objective: This study aimed to investigate trends of metabolic syndrome (MetS) and its components across the menopausal transition and to identify key metabolic risk factors in Chinese midlife women.

Method: The longitudinal study included 841 women from the Peking Union Medical College Hospital Aging Longitudinal Cohort of Women in Midlife (PALM cohort, 2005-2024), classified by the Stages of Reproductive Aging Workshop +10 (STRAW +10) criteria. Repeated measures of metabolic indicators, sex hormones and sociodemographic factors were analyzed using generalized estimating equations.

Results: MetS prevalence rose from 15.0% in the reproductive stage to 43.9% in late postmenopause. All components except reduced high-density lipoprotein cholesterol (HDL-C) increased progressively. After adjustment, perimenopause and postmenopause stages showed higher MetS odds than the reproductive stage (p = 0.008), with the highest observed in the early postmenopause stage (odds ratio = 1.796, 95% confidence interval = 1.224-2.634), primarily driven by central obesity and elevated triglycerides. Age, follicle stimulating hormone (FSH) and estradiol (E2) were independently associated with MetS risk. Lower education and poor self-rated health correlated with higher MetS risk. Vasomotor symptoms were significantly associated with central obesity (p = 0.012) and elevated triglycerides (p < 0.001).

Conclusion: The menopausal transition is a critical period for metabolic deterioration. Central obesity and elevated triglycerides are key markers. Early identification and targeted intervention are essential during this transition.

目的:本研究旨在探讨中国中年妇女绝经期代谢综合征(MetS)及其组成因素的变化趋势,并确定关键的代谢危险因素。方法:纵向研究纳入2005-2024年北京协和医院中年妇女老龄化纵向队列(PALM队列,2005-2024)841名妇女,按生殖老龄化工作坊+10 (STRAW +10)分期标准进行分类。使用广义估计方程对代谢指标、性激素和社会人口因素的重复测量进行分析。结果:met患病率从生殖期的15.0%上升到绝经后晚期的43.9%。除降低的高密度脂蛋白胆固醇(HDL-C)外,所有成分均逐渐升高。经调整后,围绝经期和绝经后阶段的MetS发生率高于生殖期(p = 0.008),绝经后早期最高(优势比= 1.796,95%可信区间= 1.224-2.634),主要由中心性肥胖和甘油三酯升高驱动。年龄、卵泡刺激素(FSH)和雌二醇(E2)与met风险独立相关。较低的教育程度和较差的自我评价健康状况与较高的MetS风险相关。血管舒缩症状与中心性肥胖(p = 0.012)和甘油三酯升高显著相关(p结论:绝经过渡期是代谢恶化的关键时期。中心性肥胖和甘油三酯升高是关键的标志。在这一转变过程中,早期识别和有针对性的干预至关重要。
{"title":"Menopausal transition and metabolic syndrome risk: insights from the Chinese PALM longitudinal cohort.","authors":"Jingbo Huang, Penghui Feng, Ruiyi Tang, Feiling Huang, Yubo Fan, Xuanjin Yang, Zhuolin Xie, Lingjin Yang, Xiaonan Ma, Keyang Yang, Runhua Zhang, Gaifen Liu, Min Luo, Rong Chen","doi":"10.1080/13697137.2025.2591300","DOIUrl":"https://doi.org/10.1080/13697137.2025.2591300","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate trends of metabolic syndrome (MetS) and its components across the menopausal transition and to identify key metabolic risk factors in Chinese midlife women.</p><p><strong>Method: </strong>The longitudinal study included 841 women from the Peking Union Medical College Hospital Aging Longitudinal Cohort of Women in Midlife (PALM cohort, 2005-2024), classified by the Stages of Reproductive Aging Workshop +10 (STRAW +10) criteria. Repeated measures of metabolic indicators, sex hormones and sociodemographic factors were analyzed using generalized estimating equations.</p><p><strong>Results: </strong>MetS prevalence rose from 15.0% in the reproductive stage to 43.9% in late postmenopause. All components except reduced high-density lipoprotein cholesterol (HDL-C) increased progressively. After adjustment, perimenopause and postmenopause stages showed higher MetS odds than the reproductive stage (<i>p</i> = 0.008), with the highest observed in the early postmenopause stage (odds ratio = 1.796, 95% confidence interval = 1.224-2.634), primarily driven by central obesity and elevated triglycerides. Age, follicle stimulating hormone (FSH) and estradiol (E2) were independently associated with MetS risk. Lower education and poor self-rated health correlated with higher MetS risk. Vasomotor symptoms were significantly associated with central obesity (<i>p</i> = 0.012) and elevated triglycerides (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The menopausal transition is a critical period for metabolic deterioration. Central obesity and elevated triglycerides are key markers. Early identification and targeted intervention are essential during this transition.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-15"},"PeriodicalIF":3.2,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Menarche, menopause and reproductive span in relation to frailty trajectories in Chinese women. 初潮、停经和生育跨度与中国女性脆弱轨迹的关系。
IF 3.2 4区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-07 DOI: 10.1080/13697137.2025.2601009
Cui-E Li, Yong-Yong Liu, Yu-Xuan Zhang, Bin-Bin Feng, Lin Zhu, Ruo-Wei Ma, Guo-Cui Wu

Objective: Frailty is a dynamic condition, but the influence of female reproductive factors on its long-term trajectories remains unclear. This study aimed to examine whether age at menarche (AAM), age at menopause (AMP) and reproductive span (RS) predict long-term frailty trajectories in middle-aged and older women.

Method: Data were analyzed from four waves (2011-2018) of the China Health and Retirement Longitudinal Study (CHARLS). Frailty was measured using the frailty index (FI), and trajectories were identified via latent category growth modeling (LCGM). Logistic regression and restricted cubic spline analyses assessed the associations of reproductive factors with FI trajectories.

Results: Among 2775 women, FI trajectories were classified into two groups: 'low-stable' (N = 1961) and 'high-rising' (N = 814). Compared with women who had menopause at ages 46-54 years, those with AMP ≤45 years (odds ratio [OR] = 1.377, 95% confidence interval [CI]: 1.073-1.766) or AMP ≥55 years (OR = 1.558, 95% CI: 1.113-2.181) had higher odds of following the 'high-rising' frailty trajectory. Similarly, RS < 26 years (OR = 1.810, 95% CI: 1.277-2.566) or RS ≥40 years (OR = 1.734, 95% CI: 1.123-2.678) were associated with increased odds of the 'high-rising' trajectory. AAM was not significantly associated with frailty trajectories.

Conclusions: Early or late menopause and extreme RS are associated with worsening frailty trajectories.

目的:虚弱是一种动态状态,但女性生殖因素对其长期轨迹的影响尚不清楚。本研究旨在探讨初潮年龄(AAM)、绝经年龄(AMP)和生殖跨度(RS)是否能预测中老年妇女的长期衰弱轨迹。方法:对中国健康与退休纵向研究(CHARLS) 2011-2018年四波数据进行分析。使用衰弱指数(FI)测量衰弱,并通过潜在类别增长模型(LCGM)确定轨迹。逻辑回归和限制三次样条分析评估了生殖因素与FI轨迹的关系。结果:在2775名女性中,FI轨迹分为两组:“低稳定”(N = 1961)和“高上升”(N = 814)。与46-54岁绝经的女性相比,AMP≤45年(比值比[OR] = 1.377, 95%可信区间[CI]: 1.073-1.766)或AMP≥55年(OR = 1.558, 95% CI: 1.113-2.181)的女性出现“高上升”虚弱轨迹的几率更高。同样,RS < 26年(OR = 1.810, 95% CI: 1.277-2.566)或RS≥40年(OR = 1.734, 95% CI: 1.123-2.678)与“高上升”轨迹的几率增加相关。AAM与脆弱轨迹没有显著相关。结论:早或晚绝经和极端RS与恶化的衰弱轨迹有关。
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Climacteric
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