Epidemiology of Keratoconjunctivitis Across India from 2017 to 2019: A Multicentric Hospital-Based Study.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY Ophthalmic epidemiology Pub Date : 2024-10-01 Epub Date: 2024-02-05 DOI:10.1080/09286586.2023.2301572

Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar

{"title":"Epidemiology of Keratoconjunctivitis Across India from 2017 to 2019: A Multicentric Hospital-Based Study.","authors":"Ferdinamarie Sharmila, Mini P Singh, Jayanti Shastry, Anil C Phukan, Subashini Kaliaperumal, R K Ratho, Jagat Ram, MadhavJagannath Sathe, Avinash Ingole, DarshanaBabubhai Rathod, Benjamin Nongrum, Kannan Thiruvengadam, Rehnuma Parvez, Vineeta Malik, Muruganandam Nagarajan, Rahul Dhodapkar","doi":"10.1080/09286586.2023.2301572","DOIUrl":null,"url":null,"abstract":"Purpose: Conjunctivitis is one of the most common ocular conditions in clinical practice. Human adenoviruses have been the common causative agents known to cause epidemic kerato-conjunctivitis (EKC) in India from 1996 to 2019 with a positivity range of 13.8%-65.2%. The current study was initiated to throw light on the distribution of keratoconjunctivitis causing agents across India covering a span of 3 years.Methods: A total of 709 swabs were collected from patients in viral transport medium (VTM), and real-time PCR was done to identify agents including Adenovirus (HAdV), Enterovirus, HSV, and Chlamydia.Results: 47.8% of the samples were positive for HAdV followed by HSV (3.4%), Enterovirus (2.7%), and Chlamydia (0.6%). Overall, 386 people (54.4%) tested positive for one of these infections, with Chandigarh (88.4%) and Port Blair (71.7%) showing higher positivity rate. Pre-auricular lymphadenopathy and follicles were significantly associated with increased risk of conjunctivitis.Conclusion: Epidemiology of keratoconjunctivitis in the current study revealed HAdV to be predominant causative agent. Knowledge gained in such epidemiological studies guide us in outbreak expectations, limit antibiotic over-prescription, and enhance disease prevention.","PeriodicalId":19607,"journal":{"name":"Ophthalmic epidemiology","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic epidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09286586.2023.2301572","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Conjunctivitis is one of the most common ocular conditions in clinical practice. Human adenoviruses have been the common causative agents known to cause epidemic kerato-conjunctivitis (EKC) in India from 1996 to 2019 with a positivity range of 13.8%-65.2%. The current study was initiated to throw light on the distribution of keratoconjunctivitis causing agents across India covering a span of 3 years.

Methods: A total of 709 swabs were collected from patients in viral transport medium (VTM), and real-time PCR was done to identify agents including Adenovirus (HAdV), Enterovirus, HSV, and Chlamydia.

Results: 47.8% of the samples were positive for HAdV followed by HSV (3.4%), Enterovirus (2.7%), and Chlamydia (0.6%). Overall, 386 people (54.4%) tested positive for one of these infections, with Chandigarh (88.4%) and Port Blair (71.7%) showing higher positivity rate. Pre-auricular lymphadenopathy and follicles were significantly associated with increased risk of conjunctivitis.

Conclusion: Epidemiology of keratoconjunctivitis in the current study revealed HAdV to be predominant causative agent. Knowledge gained in such epidemiological studies guide us in outbreak expectations, limit antibiotic over-prescription, and enhance disease prevention.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

2017 年至 2019 年印度各地角结膜炎流行病学：一项基于医院的多中心研究。

目的：结膜炎是临床上最常见的眼部疾病之一。从 1996 年到 2019 年，人类腺病毒一直是导致印度流行性角结膜炎（EKC）的常见病原体，阳性率范围为 13.8%-65.2%。目前的研究旨在揭示引起角结膜炎的病原体在印度各地的分布情况，时间跨度为 3 年：方法：用病毒转运培养基（VTM）从患者身上共采集了 709 份拭子，并进行了实时 PCR 检测，以确定包括腺病毒 (HAdV)、肠道病毒、HSV 和衣原体在内的病原体：结果：47.8%的样本对 HAdV 呈阳性，其次是 HSV（3.4%）、肠道病毒（2.7%）和衣原体（0.6%）。总体而言，有 386 人（54.4%）对其中一种感染呈阳性，其中昌迪加尔（88.4%）和布莱尔港（71.7%）的阳性率较高。耳前淋巴结病变和滤泡与结膜炎风险增加有显著相关性：结论：本次研究中的角结膜炎流行病学显示，HAdV 是主要的致病因子。从此类流行病学研究中获得的知识可指导我们对疫情的预期、限制抗生素的过度使用并加强疾病预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.