Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends.

IF 4.8 2区医学 Q1 NEUROSCIENCES Neurophotonics Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI:10.1117/1.NPh.11.1.010601

Hao Lin, Dongyu Li, Jingtan Zhu, Shaojun Liu, Jingting Li, Tingting Yu, Valery V Tuchin, Oxana Semyachkina-Glushkovskaya, Dan Zhu

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Abstract

The brain diseases account for 30% of all known diseases. Pharmacological treatment is hampered by the blood-brain barrier, limiting drug delivery to the central nervous system (CNS). Transcranial photobiomodulation (tPBM) is a promising technology for treating brain diseases, due to its effectiveness, non-invasiveness, and affordability. tPBM has been widely used in pre-clinical experiments and clinical trials for treating brain diseases, such as stroke and Alzheimer's disease. This review provides a comprehensive overview of tPBM. We summarize emerging trends and new discoveries in tPBM based on over one hundred references published in the past 20 years. We discuss the advantages and disadvantages of tPBM and highlight successful experimental and clinical protocols for treating various brain diseases. A better understanding of tPBM mechanisms, the development of guidelines for clinical practice, and the study of dose-dependent and personal effects hold great promise for progress in treating brain diseases.

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经颅光生物调制治疗脑部疾病：动物和人体研究综述，包括机制和新趋势。

脑部疾病占所有已知疾病的 30%。血脑屏障限制了药物在中枢神经系统（CNS）的传输，从而阻碍了药物治疗。经颅光生物调控（tPBM）因其有效性、无创性和经济性而成为治疗脑部疾病的一项前景广阔的技术。tPBM 已被广泛应用于治疗脑部疾病（如中风和阿尔茨海默病）的临床前实验和临床试验中。本综述全面概述了 tPBM。我们根据过去 20 年中发表的 100 多篇参考文献，总结了 tPBM 的新趋势和新发现。我们讨论了 tPBM 的优缺点，并重点介绍了治疗各种脑部疾病的成功实验和临床方案。更好地了解 tPBM 的机制、制定临床实践指南以及研究剂量依赖性和个人效应为治疗脑部疾病带来了巨大的希望。

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来源期刊

Neurophotonics Neuroscience-Neuroscience (miscellaneous)

CiteScore

7.20

自引率

11.30%

发文量

114

审稿时长

21 weeks

期刊介绍： At the interface of optics and neuroscience, Neurophotonics is a peer-reviewed journal that covers advances in optical technology applicable to study of the brain and their impact on the basic and clinical neuroscience applications.