Ketogenic diet in clinical practices

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2024-02-02 DOI:10.1016/j.hnm.2024.200250
İbrahim Hakkı Çağıran , Dursun Alper Yılmaz
{"title":"Ketogenic diet in clinical practices","authors":"İbrahim Hakkı Çağıran ,&nbsp;Dursun Alper Yılmaz","doi":"10.1016/j.hnm.2024.200250","DOIUrl":null,"url":null,"abstract":"<div><p>Epilepsy is a medical condition characterized by seizures. While antiepileptic drugs can effectively control seizures in most epilepsy patients, there exists a subtype known as resistant epilepsy in which drugs prove ineffective in managing seizure activity. Furthermore, some patients experience undesirable side effects from these medications, leading to the discontinuation of antiepileptic drug use. In such situations and others like them, the ketogenic diet is recommended as an alternative treatment approach, one that does not rely on pharmacological interventions The fundamental rationale supporting the potential efficacy of the ketogenic diet in epilepsy treatment lies in the fact that, in certain circumstances such as fasting, ketone bodies are utilized as the primary energy source for neurons, as opposed to glucose. To facilitate the generation of ketone bodies while ensuring ease and flexibility of implementation, various types of ketogenic diets have been developed. The choice of ketogenic diet approach in the treatment of epilepsy can be tailored based on the individual tolerability of patients. This meta-analysis aims to consolidate the evidence regarding the impact of ketogenic diets on patients with epilepsy in clinical practice.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666149724000124/pdfft?md5=51189cc400f96cde0c35fe3e67536baa&pid=1-s2.0-S2666149724000124-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Nutrition and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666149724000124","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Epilepsy is a medical condition characterized by seizures. While antiepileptic drugs can effectively control seizures in most epilepsy patients, there exists a subtype known as resistant epilepsy in which drugs prove ineffective in managing seizure activity. Furthermore, some patients experience undesirable side effects from these medications, leading to the discontinuation of antiepileptic drug use. In such situations and others like them, the ketogenic diet is recommended as an alternative treatment approach, one that does not rely on pharmacological interventions The fundamental rationale supporting the potential efficacy of the ketogenic diet in epilepsy treatment lies in the fact that, in certain circumstances such as fasting, ketone bodies are utilized as the primary energy source for neurons, as opposed to glucose. To facilitate the generation of ketone bodies while ensuring ease and flexibility of implementation, various types of ketogenic diets have been developed. The choice of ketogenic diet approach in the treatment of epilepsy can be tailored based on the individual tolerability of patients. This meta-analysis aims to consolidate the evidence regarding the impact of ketogenic diets on patients with epilepsy in clinical practice.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
生酮饮食在临床实践中的应用
癫痫是一种以癫痫发作为特征的疾病。虽然抗癫痫药物能有效控制大多数癫痫患者的癫痫发作,但也存在一种被称为抗药性癫痫的亚型,在这种情况下,药物无法有效控制癫痫发作活动。此外,一些患者会因这些药物产生不良副作用而停止使用抗癫痫药物。支持生酮饮食在癫痫治疗中的潜在疗效的基本原理在于,在禁食等特定情况下,酮体被用作神经元的主要能量来源,而不是葡萄糖。为了促进酮体的产生,同时确保实施的简便性和灵活性,人们开发了各种类型的生酮饮食。在治疗癫痫时,可根据患者的个体耐受性选择生酮饮食方法。本荟萃分析旨在整合临床实践中有关生酮饮食对癫痫患者影响的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
期刊最新文献
Contribution of body adiposity index and conicity index in prediction of metabolic syndrome risk and components Effectiveness of nutritional supplements (vitamins, minerals, omega-3, and probiotics) in preventing and treating COVID-19 and viral respiratory infections Prevalence of hypertension and its associated risk factors during COVID-19 pandemic in the capital of Bangladesh Diet and gut microbiome: Impact of each factor and mutual interactions on prevention and treatment of type 1, type 2, and gestational diabetes mellitus Dietary practices of type 2 diabetes mellitus patients concerning Pender's health Promotion Model in Lalitpur district, Nepal
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1