Ketogenic diet in clinical practices

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2024-02-02 DOI:10.1016/j.hnm.2024.200250
İbrahim Hakkı Çağıran , Dursun Alper Yılmaz
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Abstract

Epilepsy is a medical condition characterized by seizures. While antiepileptic drugs can effectively control seizures in most epilepsy patients, there exists a subtype known as resistant epilepsy in which drugs prove ineffective in managing seizure activity. Furthermore, some patients experience undesirable side effects from these medications, leading to the discontinuation of antiepileptic drug use. In such situations and others like them, the ketogenic diet is recommended as an alternative treatment approach, one that does not rely on pharmacological interventions The fundamental rationale supporting the potential efficacy of the ketogenic diet in epilepsy treatment lies in the fact that, in certain circumstances such as fasting, ketone bodies are utilized as the primary energy source for neurons, as opposed to glucose. To facilitate the generation of ketone bodies while ensuring ease and flexibility of implementation, various types of ketogenic diets have been developed. The choice of ketogenic diet approach in the treatment of epilepsy can be tailored based on the individual tolerability of patients. This meta-analysis aims to consolidate the evidence regarding the impact of ketogenic diets on patients with epilepsy in clinical practice.

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生酮饮食在临床实践中的应用
癫痫是一种以癫痫发作为特征的疾病。虽然抗癫痫药物能有效控制大多数癫痫患者的癫痫发作,但也存在一种被称为抗药性癫痫的亚型,在这种情况下,药物无法有效控制癫痫发作活动。此外,一些患者会因这些药物产生不良副作用而停止使用抗癫痫药物。支持生酮饮食在癫痫治疗中的潜在疗效的基本原理在于,在禁食等特定情况下,酮体被用作神经元的主要能量来源,而不是葡萄糖。为了促进酮体的产生,同时确保实施的简便性和灵活性,人们开发了各种类型的生酮饮食。在治疗癫痫时,可根据患者的个体耐受性选择生酮饮食方法。本荟萃分析旨在整合临床实践中有关生酮饮食对癫痫患者影响的证据。
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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