A high-resolution view of the heterogeneous aging endothelium

IF 9.2 1区医学 Q1 PERIPHERAL VASCULAR DISEASE Angiogenesis Pub Date : 2024-02-07 DOI:10.1007/s10456-023-09904-6

Sarah Dobner, Fanni Tóth, Laura P. M. H. de Rooij

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Abstract

Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While studies confined to the investigation of aging-associated vascular readouts in one or a few tissues have already drastically expanded our understanding of EC aging, single-cell omics and other high-resolution profiling technologies have started to illuminate the intricate molecular changes underlying endothelial aging across diverse tissues and vascular beds at scale. In this review, we provide an overview of recent insights into the heterogeneous adaptations of the aging vascular endothelium. We address critical questions regarding tissue-specific and universal responses of the endothelium to the aging process, EC turnover dynamics throughout lifespan, and the differential susceptibility of ECs to acquiring aging-associated traits. In doing so, we underscore the transformative potential of single-cell approaches in advancing our comprehension of endothelial aging, essential to foster the development of future innovative therapeutic strategies for aging-associated vascular conditions.

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高分辨率观察异质性老化内皮。

血管内皮细胞（EC）老化对组织灌注和整体心血管健康有很大影响。虽然局限于调查一种或几种组织中与老化相关的血管读数的研究已经极大地扩展了我们对血管内皮细胞老化的认识，但单细胞全息技术和其他高分辨率剖析技术已经开始大规模地揭示不同组织和血管床中内皮老化背后错综复杂的分子变化。在这篇综述中，我们概述了最近对老化血管内皮异质性适应性的见解。我们探讨了以下关键问题：内皮对衰老过程的组织特异性和普遍性反应、整个生命周期中内皮细胞的更替动态以及内皮细胞对获得衰老相关特征的不同易感性。在此过程中，我们强调了单细胞方法在推进我们对内皮老化的理解方面所具有的变革潜力，这对促进未来针对老化相关血管疾病的创新治疗策略的开发至关重要。

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来源期刊

Angiogenesis PERIPHERAL VASCULAR DISEASE-

CiteScore

21.90

自引率

8.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.