Correlation of fitzpatrick skin type and iris color with tumor size in 823 patients with uveal melanoma

IF 3.7 3区 医学 Q1 OPHTHALMOLOGY Asia-Pacific Journal of Ophthalmology Pub Date : 2024-03-01 DOI:10.1016/j.apjo.2024.100046
Kushal U. Agrawal, Matthew R. Barke, Lawrence Chiang, Roselind Ni, Rachel S. Kim, Qiang Zhang, Carol L. Shields
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Abstract

Purpose

To determine the correlation of Fitzpatrick Skin Type (FST) and iris color with tumor size (tumor thickness and basal diameter) in patients with uveal melanoma.

Design

Retrospective Cohort

Methods

Retrospective cohort from a single ocular oncology center of 823 patients with uveal melanoma and documented FST, iris color, and tumor size. Patients were classified by FST (type I, II, and III–V) and iris color (blue, green, and brown) on the basis of external facial photography. There were no FST type VI patients. Tumor thickness was classified into small [< 3 millimeter (mm)], medium (3.1–8.0 mm), or large (> 8.0 mm), and basal diameter into small (< 10 mm), medium (10.1–15 mm) or large (> 15 mm). The correlation of FST and iris color with tumor thickness and basal diameter was evaluated using the Kruskal-Wallis H test.

Results

The FST classification was type I (n = 92, 11%), type II (n = 643, 78%), or III–V (n = 88, 11%), and iris color was blue (n = 472, 57%), green (n = 102, 12%), or brown (n = 249, 30%). A comparison of FST revealed differences in mean tumor thickness (P = 0.04) and basal diameter (P = 0.006). Iris color showed no difference for mean tumor thickness (P = 0.41) or basal diameter (P = 0.48). There was a statistically significant difference with brown iris color relative to FST III–V for mean tumor thickness (P = 0.003) and basal diameter (P = 0.001) but no difference with blue or green iris color (P > 0.05).

Conclusions

Iris color alone showed no difference in tumor size, but those with brown iris color and FST type III–V demonstrated larger tumor thickness and basal diameter.

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823 名葡萄膜黑色素瘤患者的菲茨帕特里克皮肤类型和虹膜颜色与肿瘤大小的相关性。
目的:确定葡萄膜黑色素瘤患者的菲茨帕特里克皮肤类型(FST)和虹膜颜色与肿瘤大小(肿瘤厚度和基底直径)的相关性:回顾性队列方法:来自一家眼部肿瘤中心的回顾性队列,共有 823 名葡萄膜黑色素瘤患者,并记录了 FST、虹膜颜色和肿瘤大小。根据外部面部照片,按 FST(I 型、II 型和 III-V 型)和虹膜颜色(蓝色、绿色和棕色)对患者进行分类。没有 FST VI 型患者。肿瘤厚度分为小型(< 3 毫米)、中型(3.1-8.0 毫米)和大型(> 8.0 毫米),基底直径分为小型(< 10 毫米)、中型(10.1-15 毫米)和大型(> 15 毫米)。采用 Kruskal-Wallis H 检验评估了 FST 和虹膜颜色与肿瘤厚度和基底直径的相关性:FST分类为I型(92人,占11%)、II型(643人,占78%)或III-V型(88人,占11%),虹膜颜色为蓝色(472人,占57%)、绿色(102人,占12%)或棕色(249人,占30%)。FST 比较显示,平均肿瘤厚度(P = 0.04)和基底直径(P = 0.006)存在差异。虹膜颜色在肿瘤平均厚度(P = 0.41)和基底直径(P = 0.48)方面没有差异。相对于 FST III-V,棕色虹膜颜色在肿瘤平均厚度(P = 0.003)和基底直径(P = 0.001)方面有显著统计学差异,但与蓝色或绿色虹膜颜色没有差异(P > 0.05):结论:单纯虹膜颜色与肿瘤大小无差异,但棕色虹膜颜色和 FST III-V 型患者的肿瘤厚度和基底直径更大。
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来源期刊
CiteScore
8.10
自引率
18.20%
发文量
197
审稿时长
6 weeks
期刊介绍: The Asia-Pacific Journal of Ophthalmology, a bimonthly, peer-reviewed online scientific publication, is an official publication of the Asia-Pacific Academy of Ophthalmology (APAO), a supranational organization which is committed to research, training, learning, publication and knowledge and skill transfers in ophthalmology and visual sciences. The Asia-Pacific Journal of Ophthalmology welcomes review articles on currently hot topics, original, previously unpublished manuscripts describing clinical investigations, clinical observations and clinically relevant laboratory investigations, as well as .perspectives containing personal viewpoints on topics with broad interests. Editorials are published by invitation only. Case reports are generally not considered. The Asia-Pacific Journal of Ophthalmology covers 16 subspecialties and is freely circulated among individual members of the APAO’s member societies, which amounts to a potential readership of over 50,000.
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