Advancing Understanding of Childhood Asthma: Lessons Learned from Birth Cohort Studies.

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2024-02-01 Epub Date: 2024-02-07 DOI:10.1007/s12016-024-08979-3
Yuhan Xing, Xinmeng Yang, Zhaoyinqian Li, Qiyuan Zou, Ping Yang, Qinzheng Wang, Wei Ni, Dongze Wu, Guoju Li
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Abstract

Asthma and allergies are some of the most common chronic disorders affecting children, the prevalence of which has been increasing in countries and regions undergoing rapid development like China. To curb the rising tide of allergies and safeguard the health of future generations, it is of critical importance to understand how asthma inception is influenced by factors acting at different life stages. Birth cohorts represent a powerful tool to investigate the temporal sequence of exposures along the natural course of asthma. We examined recent evidence on birth cohort studies of asthma and allergic diseases and evaluated their strengths and weaknesses. Essential elements for a successful birth cohort are proposed to further elucidate asthma etiology and pathogenies. Initiating new cohorts in understudied populations with the application of advanced analytical approaches will be needed. Moreover, fostering collaborative networks using standardized methodologies should be prioritized to enable integration of findings across diverse cohorts. There remains an urgent and unmet need to further translate the seminal findings from asthma birth cohort studies into targeted primary prevention strategies to eradicate the disease.

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增进对儿童哮喘的了解:从出生队列研究中吸取经验教训。
哮喘和过敏是影响儿童的一些最常见的慢性疾病,在像中国这样快速发展的国家和地区,其发病率不断上升。为了遏制过敏症的上升趋势,保障后代的健康,了解哮喘的发病是如何受到不同生命阶段因素的影响至关重要。出生队列是研究哮喘自然病程中暴露因素时间序列的有力工具。我们研究了最近有关哮喘和过敏性疾病出生队列研究的证据,并评估了其优缺点。我们提出了成功的出生队列研究的基本要素,以进一步阐明哮喘的病因和发病机制。需要在研究不足的人群中启动新的队列研究,并应用先进的分析方法。此外,应优先考虑利用标准化方法建立合作网络,以便整合不同队列的研究结果。将哮喘出生队列研究的开创性发现进一步转化为有针对性的初级预防策略,以根除这一疾病,仍是一项迫切且尚未得到满足的需求。
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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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