Oral manifestations after vaccinations: A systematic review of observational studies.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-09-01 Epub Date: 2024-02-06 DOI:10.1111/odi.14883

Sabrina Messina, Patrizia Natale, Giusi Graziano, Sara Galleggiante, Giovanni F M Strippoli, Massimo Petruzzi

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引用次数: 0

Abstract

Objective: This study aimed to assess the prevalence and types of oral adverse events following immunization (AEFIs) in people who received at least one dose of any type of vaccine.

Materials and methods: We conducted a bibliographic search about oral AEFIs in MEDLINE, Embase, PubMed, and Ovid from database inception to November 07, 2022. Risk of bias was assessed using the MURAD or the Quality In Prognosis Studies tools. Random-effects proportional meta-analysis was applied.

Results: A total of 119 studies involving 343 people were eligible. These reported AEFIs occurred following administration of the coronavirus disease 2019 vaccine, anti-influenza vaccine, hepatitis B vaccine, and anti-smallpox vaccine. The most common to be affected in vaccinated people were buccal mucosa (63.1%; 95% confidence interval (CI) 33.4-88.2) and lips (55.7%; 95% CI, 41.1-69.8). The most prevalent oral AEFIs were ulceration (55.2%; 95% CI 24.4-84.0), swelling (65.2%; 95% CI 34.9-89.8), and burning sensation (18.3%; 95% CI 7.9-31.8).

Conclusions: The mechanisms underlying oral AEFIs should be further investigated to promptly recognize oral manifestations and provide optimal management for people undergoing vaccination.

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接种疫苗后的口腔表现：观察性研究的系统回顾。

研究目的本研究旨在评估至少接种过一剂任何类型疫苗的人群中免疫接种后口腔不良事件（AEFIs）的发生率和类型：我们在 MEDLINE、Embase、PubMed 和 Ovid 中进行了有关口腔 AEFIs 的文献检索，检索时间为数据库建立至 2022 年 11 月 7 日。使用MURAD或预后研究质量工具评估了偏倚风险。采用随机效应比例荟萃分析：共有 119 项研究符合条件，涉及 343 人。这些报告的AEFI发生在接种2019年冠状病毒病疫苗、抗流感疫苗、乙肝疫苗和抗天花疫苗之后。接种者最常受影响的部位是口腔粘膜（63.1%；95% 置信区间 (CI)，33.4-88.2）和嘴唇（55.7%；95% 置信区间 (CI)，41.1-69.8）。最常见的口腔 AEFI 为溃疡（55.2%；95% CI 24.4-84.0）、肿胀（65.2%；95% CI 34.9-89.8）和烧灼感（18.3%；95% CI 7.9-31.8）：结论：应进一步研究口腔 AEFI 的发病机制，以便及时发现口腔表现，为接受疫苗接种的人群提供最佳治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.