Vaccine Safety: Assessing the Prevalence and Severity of Adverse Events Following COVID-19 Vaccination amongst Healthcare Workers in Tertiary Health Facilities in Nigeria.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Nigerian Postgraduate Medical Journal Pub Date : 2024-01-01 Epub Date: 2024-02-07 DOI:10.4103/npmj.npmj_227_23
Ayotunde Sherif Azees, Mojirola Martina Fasiku, Abdulfattah Isa, Ahuna Zainab Ezenwoko, Abdullahi Ahmed, Abiola Oluwatoyin Temitayo-Oboh, Rowland Utulu, Makinde Adebayo Adeniyi, Abubakar Musa, Chihurumnanya Alo, Usman Muhammed Ibrahim, Gloria Bosede Imhonopi, Oluwaseun Opeyemi Adesoye, Ifeyinwa Maureen Okeke, Godwin ThankGod John, Abdulquadri Yeketi Ayinla
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Abstract

Background: Vaccines, including COVID-19 vaccines, are known to be cost-effective interventions for disease prevention and control. However, adverse events following immunisation (AEFI) may challenge the acceptance of these vaccines. This study assessed the prevalence and severity of COVID-19-related AEFI amongst healthcare workers at tertiary health facilities in Nigeria.

Materials and methods: This descriptive, cross-sectional study was conducted among healthcare workers who had received the COVID-19 vaccine. A multi-stage sampling technique was used to select participants from six Tertiary Health Facilities in Nigeria. Ethical approval (NHREC/01/01/2007-19/07/2021) was obtained from NHREC. Data were analysed using IBM® SPSS version 25 and categorical variables were presented in tables/charts using frequencies and proportions.

Results: A total of 2130 respondents participated in the study, with a mean age of 37.4 ± 9.1 years. Most of the respondents, 1674 (78.6%), had two doses of the vaccine, and the overall prevalence of AEFI was 813 (38.2%). Common among the AEFI reported following the administration of the first dose of the vaccine were fever 649 (30.5%) and pain at the injection site 644 (30.2%), while it was pain at the injection site 216 (10.1%) and fever 173 (8.1%) for second dose. The higher proportions of AEFI were mostly mild to moderate.

Conclusion: The study observed a relatively low prevalence of AEFI, with the commonly reported ones being fever and injection site pain. It is crucial that countries continuously collect the data on AEFI and establish causality as a way to improve quality and guarantee vaccine safety.

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疫苗安全:评估尼日利亚三级医疗机构医护人员接种 COVID-19 疫苗后不良事件的发生率和严重程度。
背景:众所周知,包括 COVID-19 疫苗在内的疫苗是具有成本效益的疾病预防和控制干预措施。然而,免疫接种后的不良反应(AEFI)可能会影响人们对这些疫苗的接受程度。本研究评估了尼日利亚三级医疗机构医护人员中与 COVID-19 疫苗相关的 AEFI 的发生率和严重程度:这项描述性横断面研究在接种过 COVID-19 疫苗的医护人员中进行。研究采用多阶段抽样技术,从尼日利亚的六家三级医疗机构中挑选参与者。研究获得了尼日利亚国家卫生与健康委员会的伦理批准(NHREC/01/01/2007-19/07/2021)。数据使用 IBM® SPSS 第 25 版进行分析,分类变量使用频率和比例以表格/图表的形式呈现:共有 2130 名受访者参与了研究,平均年龄为 37.4 ± 9.1 岁。大多数受访者(1674 人(78.6%))接种过两剂疫苗,AEFI 的总发病率为 813 人(38.2%)。在接种第一剂疫苗后报告的 AEFI 中,常见的是发烧 649 例(30.5%)和注射部位疼痛 644 例(30.2%),而接种第二剂疫苗时,常见的是注射部位疼痛 216 例(10.1%)和发烧 173 例(8.1%)。较高比例的 AEFI 多为轻度至中度:研究发现,AEFI 的发生率相对较低,常见的是发烧和注射部位疼痛。至关重要的是,各国应持续收集 AEFI 数据并确定因果关系,以此提高疫苗质量并保证疫苗安全。
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来源期刊
Nigerian Postgraduate Medical Journal
Nigerian Postgraduate Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.90
自引率
0.00%
发文量
52
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