Amir Akhavanrezayat, Gunay Uludag Kirimli, Wataru Matsumiya, Hassan Khojasteh, Christopher Or, Irmak Karaca, Brandon Pham, Prapatsorn Ongpalakorn, Sherin Lajevardi, Brandon Lam, Jaclyn Joyce Hwang, Ngoc Trong Tuong Than, SungWho Park, Negin Yavari, Vahid Bazojoo, Azadeh Mobasserian, Anadi Khatri, Muhammad Sohail Halim, Zheng Xian Thng, Hashem Ghoraba, Diana V Do, Ilknur Tugal-Tutkun, Vishali Gupta, Marc de Smet, Quan Dong Nguyen
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引用次数: 0
Abstract
Purpose: The index review aims to provide an update on the role of corticosteroids and steroid-sparing immunomodulatory therapy (IMT) in managing patients with infectious uveitis.
Method: Narrative literature review.
Results: Corticosteroids and immunomodulatory therapy (IMT) focus on the host defense system instead of the pathogen, adjusting exaggerated inflammatory reactions to reduce potential harm to ocular tissues. Systemic or local corticosteroids are primarily selected as adjunctive medication for infectious uveitis. Concomitant corticosteroids have also been used in cases of paradoxical worsening in ocular tuberculosis and immune recovery uveitis in cytomegalovirus (CMV) retinitis. While there is no well-established evidence to support the use of IMT in infectious uveitis, it is occasionally used in clinical settings to treat persistent inflammation following resolution of infection such as cases of ocular tuberculosis and ocular syphilis where an insufficient response is observed with corticosteroids.
Conclusion: There is no consensus on the position of immunomodulatory therapy in the management of infectious uveitis with different etiologies. The index review provides an overview of available adjunctive corticosteroids and IMT options to assist clinicians in managing such disease entities more efficiently.
期刊介绍：
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.
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