Autoimmune, Autoinflammatory Disease and Cutaneous Malignancy Associations with Hidradenitis Suppurativa: A Cross-Sectional Study.

IF 8.6 1区医学 Q1 DERMATOLOGY American Journal of Clinical Dermatology Pub Date : 2024-05-01 Epub Date: 2024-02-09 DOI:10.1007/s40257-024-00844-5

Hilliard T Brydges, Ogechukwu C Onuh, Rebecca Friedman, Joy Barrett, Rebecca A Betensky, Catherine P Lu, Avrom S Caplan, Afsaneh Alavi, Ernest S Chiu

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Abstract

Background: Hidradenitis suppurativa (HS) is a debilitating cutaneous disease characterized by severe painful inflammatory nodules/abscesses. At present, data regarding the epidemiology and pathophysiology of this disease are limited.

Objective: To define the prevalence and comorbidity associations of HS.

Methods: This was a cross-sectional study of EPIC^TM Cosmos^© examining over 180 million US patients. Prevalences were calculated by demographic and odds ratios (OR) and identified comorbidity correlations.

Results: All examined metabolism-related, psychological, and autoimmune/autoinflammatory (AI) diseases correlated with HS. The strongest associations were with pyoderma gangrenosum [OR 26.56; confidence interval (CI): 24.98-28.23], Down syndrome (OR 11.31; CI 10.93-11.70), and polycystic ovarian syndrome (OR 11.24; CI 11.09-11.38). Novel AI associations were found between HS and lupus (OR 6.60; CI 6.26-6.94) and multiple sclerosis (MS; OR 2.38; CI 2.29-2.48). Cutaneous malignancies were largely not associated in the unsegmented cohort; however, among Black patients, novel associations with melanoma (OR 2.39; CI 1.86-3.08) and basal cell carcinoma (OR 2.69; CI 2.15-3.36) were identified.

Limitations: International Classification of Diseases (ICD)-based disease identification relies on coding fidelity and diagnostic accuracy.

Conclusion: This is the first study to identify correlations between HS with melanoma and basal cell carcinoma (BCC) among Black patients as well as MS and lupus in all patients with HS.

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自身免疫性疾病、自身炎症性疾病和皮肤恶性肿瘤与扁平苔藓的关联：一项横断面研究

背景：化脓性扁平湿疹（HS）是一种使人衰弱的皮肤病，其特征是严重疼痛的炎性结节/脓肿。目前，有关该病流行病学和病理生理学的数据十分有限：方法：这是一项横断面研究，研究对象为美国、加拿大、英国、法国、德国、日本、韩国和中国：这是 EPICTM Cosmos© 的一项横断面研究，对超过 1.8 亿美国患者进行了检查。通过人口统计学和几率比（OR）计算患病率，并确定合并症的相关性：结果：所有受检的代谢相关疾病、心理疾病和自身免疫/自体炎症（AI）疾病均与 HS 相关。与脓皮病[OR 26.56；置信区间（CI）：24.98-28.23]、唐氏综合征（OR 11.31；CI 10.93-11.70）和多囊卵巢综合征（OR 11.24；CI 11.09-11.38）的相关性最强。在 HS 与狼疮（OR 6.60；CI 6.26-6.94）和多发性硬化症（MS；OR 2.38；CI 2.29-2.48）之间发现了新的 AI 关联。皮肤恶性肿瘤在未分段队列中基本没有关联；但在黑人患者中，发现了与黑色素瘤（OR 2.39；CI 1.86-3.08）和基底细胞癌（OR 2.69；CI 2.15-3.36）的新关联：局限性：基于国际疾病分类（ICD）的疾病识别依赖于编码的准确性和诊断的准确性：这是首次在黑人患者中发现 HS 与黑色素瘤和基底细胞癌 (BCC) 之间的相关性，以及在所有 HS 患者中发现 MS 与狼疮之间的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Clinical Dermatology 医学-皮肤病学

CiteScore

15.20

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.