Effects of dried okra extract on lipid profile, renal function and some RAGE-related inflammatory genes expression in patients with diabetic nephropathy: A randomized controlled trial

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-02-07 DOI:10.1016/j.ctim.2024.103027

Nazgol Bahreini , Maryam Saghafi-Asl , Omid Nikpayam , Ehsan Safaei , Vahideh Sadra , Laleh Fakhr , Hanieh Beyrampour-Basmenj , Parina Asgharian , Mohammad Asghari- Jafarabadi

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Abstract

Background

Diabetic nephropathy (DN) is a common complication of type 2 diabetes. Okra (Abelmoschus esculentus L) is reported to have anti-diabetic effects. The present study aimed to investigate the effects of dried okra extract (DOE) supplementation on lipid profile, renal function indices, and expression of inflammatory genes, as well as serum level of soluble Receptor for Advanced glycation end products (sRAGE) in patients with DN.

Methods

In this triple-blind randomized placebo-controlled clinical trial, 64 eligible patients with DN received either 125 mg of DOE or placebo daily along with DN-related nutritional recommendations for 10 weeks. Changes in kidney indices including proteinuria and estimated glomerular filtration rate (eGFR), lipid profile, serum SRAGE, as well as the expression of RAGE, ICAM-1, and IL-1 genes were measured over 10 weeks.

Results

After adjustment for the potential confounders, between-group analyses showed no significant differences in terms of lipid profile, kidney function indices, sRAGE, and RAGE-related inflammatory genes expression after 10 weeks.

Conclusion

Daily 125 mg DOE along with nutritional recommendations on top of usual care did not lead to significant changes in renal function indices, lipid profile, and inflammatory genes expression in patients with DN.

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干秋葵提取物对糖尿病肾病患者血脂、肾功能和一些 RAGE 相关炎症基因表达的影响：随机对照试验

背景：糖尿病肾病（DN糖尿病肾病（DN）是 2 型糖尿病的常见并发症。据报道，秋葵（Abelmoschus esculentus L）具有抗糖尿病作用。本研究旨在探讨补充秋葵干提取物（DOE）对糖尿病肾病患者血脂、肾功能指数、炎症基因表达以及血清可溶性高级糖化终产物受体（sRAGE）水平的影响：在这项三盲随机安慰剂对照临床试验中，64 名符合条件的 DN 患者每天服用 125 毫克 DOE 或安慰剂，同时接受与 DN 相关的营养建议，为期 10 周。在 10 周的时间里，测量了包括蛋白尿和估计肾小球滤过率 (eGFR)、血脂概况、血清 SRAGE 以及 RAGE、ICAM-1 和 IL-1 基因表达在内的肾脏指数的变化：结果：在对潜在的混杂因素进行调整后，组间分析表明，10 周后，血脂、肾功能指数、血清 SRAGE 和 RAGE 相关炎症基因的表达均无显著差异：结论：在常规治疗的基础上，每天服用 125 毫克 DOE 和营养建议不会导致 DN 患者的肾功能指数、血脂状况和炎症基因表达发生显著变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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