Complementary therapies in medicine最新文献

Effect of music intervention on dental anxiety and fear: A bibliometric analysis of RCTs from 2004 to 2024

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-26 DOI: 10.1016/j.ctim.2025.103148

Yena Gan , Jinwei Huang , Sheng Han , He Xu , He Zhu , Duoduo Li , Zening Wei , Feng Sun , Zhigang Cai

Background

Dental treatments, especially invasive procedures, often induce anxiety and fear, impacting future treatment adherence. Music intervention, a non-pharmacological approach, has shown promise in reducing anxiety and enhancing well-being, but further research is needed to explore its application in dental settings and the influence of factors like music type, duration, and volume.

Objective

To assess the effects of music interventions on dental anxiety and fear, analyze research trends, and identify knowledge gaps through a bibliometric analysis of randomized controlled trials.

Methods

Data from eligible studies were extracted through a comprehensive search. Descriptive bibliometrics, citation analysis, and keyword analysis were performed to assess research outputs, distribution, hotspots, and trends. Different human development indices (HDI) were used to analyze variations in publication year, sex distribution, and interventions across countries.

Results

This study included 46 randomized controlled trials (RCTs) from 2004 to 2024, with a mean annual growth rate of 5.95 %. India, Japan, and Turkey led the research output and citations. Approximately 4112 participants, with 45.68 % males were enrolled. Most RCTs focused on adults (65.22 %) and used passive music interventions (73.91 %). The most common treatment was dental extraction (39.13 %), with classical music being the predominant intervention (60.87 %). The control group were often blank (80.43 %). Various indicators of anxiety and fear have been reported. Significant differences were found in the sex distribution among the different HDI ranks (p < 0.001).

Conclusions

This study outlined the research profile of music interventions for reducing anxiety and fear during dental treatments, with India, Japan, and Turkey leading in terms of output. The most frequently studied intervention is classical music, which is typically used preoperatively. Notable sex distribution differences were observed across HDI groups. Future research trends should include more extensive trials, personalized interventions, standardized guidelines, and enhanced collaboration to optimize patient engagement and emotional regulation.

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引用次数: 0

The State of Evidence in Acupuncture A Review of Metaanalyses and Systematic Reviews of Acupuncture Evidence Update 2017 to 2022.

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-26 DOI: 10.1016/j.ctim.2025.103149

Moritz Hempen, Josef Hummelsberger

Introduction: Over the last decades, acupuncture research has increased drastically. As a result, it has become more and more difficult to oversee the amount of evidence concerning its effect in various medical conditions. Different comparative reviews aimed to roughly assess individual strength of acupuncture evidence, covering the years 2005 - 2017. Our review intends to assess the level of acupuncture evidence for any medical condition available, concerning the years 2017 - 2022.

Methods: We searched the pubmed database for 'acupuncture' and filtered the results towards systematic reviews and metanalyses (SR/MA). Results were allocated towards medical disciplines and sorted to medical conditions. Each SR/MA was rated concerning quality of review (QoR), quality of data (QoD), and quality of evidence (QoE). To facilitate a rough overview, results were assessed into either of four categories: i) evidence of positive effect, ii) evidence of potential positive effect, iii) insufficient/unclear evidence, iv) no evidence of effect / evidence of no effect.

Results: After considering exclusion criteria, 862 SR/MA remained for evaluation. Results were allocated and sorted as described, resulting in 184 medical conditions. Of these, in ten medical conditions SR/MA supported evidence of positive effect: chronic pain, low-back pain, knee osteoarthritis, postoperative nausea and vomiting (PONV), migraine, tension-type headache, cancer-related fatigue, menopausal symptoms, female infertility (additional to medical reproductive treatment), chronic prostatitis / chronic pelvic pain syndrome in men. In another 82 medical conditions SR/MA supported evidence of potential positive effect, in another 86 medical conditions SR/MA revealed unclear/insufficient evidence, and in another six medical conditions no evidence of effect / evidence of no effect was found. Compared with previous reviews until the year 2017, the number of medical conditions with higher quality evidence levels has increased, namely evidence of positive effect and evidence of potential positive effect.

Discussion and conclusion: Compared to previous years, the amount and quality of acupuncture's evidence has increased in the years 2017 to 2022. In total, 862 included SR/MA resulted in a comparative review of 184 medical conditions. Evidence of positive effect was revealed ten medical conditions, another 82 showed evidence of potential positive effect. 86 medical indications revealed for a firm conclusion, six conditions showed no evidence of effect / evidence of no effect. Although general quality of evidence has dramatically increased compared to the previous years, lack of underlying high-quality trials in some cases seems to compromise a consistent comparability between SR/MA. This issue should be addressed for future studies and guidelines such as STRICTA and CONSORT should strictly be obtained.

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引用次数: 0

Oral probiotic supplementation to alleviate diarrhea induced by fluoropyrimidines or irinotecan-based chemotherapy: A systematic review and meta-analysis 口服益生菌补充剂缓解氟嘧啶类药物或伊立替康化疗引起的腹泻：系统综述和荟萃分析。

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-22 DOI: 10.1016/j.ctim.2025.103151

Tippawan Siritientong , Daylia Thet , Nattawut Leelakanok , Nutthada Areepium

Background

Fluoropyrimidines and irinotecan cause diarrhea, which can be particularly severe in some cases. Probiotic supplementation is a potential option for managing chemotherapy-induced diarrhea. This study aims to evaluate the efficacy and safety of probiotics in managing diarrhea induced by fluoropyrimidine or irinotecan-based chemotherapy in cancer patients.

Methods

A literature search was conducted in Cochrane Library, PubMed, ScienceDirect, SciFinder, and Scopus in August 2023. Observational and prospective studies of cancer patients receiving 5-fluorouracil, capecitabine, or irinotecan were included. RevMan (version 5.4.1) was used for statistical analysis. The study protocol was registered in PROSPERO.

Results

Of the 9400 records, 24 and 14 studies were included in the systematic review and meta-analysis, respectively. Most studies provided a combination of probiotic strains to patients from the initiation to the completion of chemotherapy cycles. Probiotic supplementation significantly reduced all grade diarrhea (RR = 0.40; 95 % CI: 0.27, 0.60; P < 0.00001, I²: 0 %), nausea and vomiting (RR = 0.49; 95 % CI [0.37, 0.67]; P < 0.00001, I²: 0 %), bloating (RR = 0.27; 95 % CI [0.11, 0.69]; P = 0.006, I²: 0 %) and anorexia (RR = 0.62: 95 % CI [0.43, 0.90]; P = 0.01, I²: 39 %) compared to controls. Absolute risk reductions (ARR) ranged from 22.7 % to 28.5 %, with the number needed to treat (NNT) value of 3–5. Moreover, probiotics improved intestinal microbial balance and symptom scales of quality of life.

Conclusions

Probiotic supplementation is a promising option to manage chemoradiotherapy-induced diarrhea without serious side effects in cancer patients receiving fluoropyrimidines or irinotecan-based regimens. Given the clinically meaningful ARR and favorable NNT values, probiotics may have a role in clinical practice. However, larger trials are needed to standardize probiotic strain, dosage, duration, and target patient subgroups.

Systematic review registration

PROSPERO database (CRD42023473324)

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引用次数: 0

Efficacy of melatonin as adjunctive therapy for sepsis: A meta-analysis of randomized controlled trials

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-21 DOI: 10.1016/j.ctim.2025.103147

Zhuangzhuang Sun , Cheng Yu , Zhaopeng Zhang , Chunjie Hu , Xin Li , Xiheng Dong , Ru Zhang , Zhirun Zhang , Tonggang Zhu , Xin Su , Junpeng Guo

Background

This study systematically evaluates the therapeutic efficacy of melatonin as an adjunctive therapy, aiming to determine its potential to reduce mortality and mitigate inflammatory responses in patients with sepsis.

Methods

A search was conducted across PubMed, Web of Science, Cochrane Library, and Embase databases. The Cochrane Collaboration Risk of Bias (ROB) tool was systematically employed to assess the potential for bias in the relevant studies. The I² statistic was employed to evaluate heterogeneity among the studies. Potential publication bias was assessed using Begg's test. Sensitivity analysis was performed to examine the stability of the results. Additionally, a GRADE evaluation of the evidence level.

Results

This meta-analysis encompassed a total of seven randomized controlled trials involving 421 patients diagnosed with sepsis. The primary results indicated that the mortality rate in the intervention group was significantly lower than that in the control group, suggesting that melatonin may effectively reduce mortality among sepsis patients [OR = 0.42, 95 % CI: 0.23–0.77, P = 0.005]. Additionally, the CRP levels in the intervention group were markedly lower than those in the control group, providing evidence that melatonin possesses anti-inflammatory properties that may help decrease inflammatory markers in sepsis patients [SMD= -4.00, 95 % CI: −6.47 to −1.53, P = 0.001]. Furthermore, Secondary outcome results showed no statistically significant differences in sequential organ failure assessment (SOFA) scores, length of hospital stay, and adverse effects. A sensitivity analysis confirmed the robustness of the findings from the included studies. By applying the GRADE system to evaluate the quality of evidence, we found the evidence in four grades: one rated as high quality, one as medium quality, and three rated as low quality.

Conclusion

Melatonin, when used as an adjuvant therapy, significantly reduces mortality and lowers the levels of the inflammatory marker CRP in patients with sepsis, while also improving their physical condition. However, due to the limited number and quality of the articles, these conclusions warrant further verification through the conduct of additional high-quality research.

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引用次数: 0

Influence of Referent selection on Balance in Action Observation: A Randomized Controlled Trial.

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-20 DOI: 10.1016/j.ctim.2025.103150

Tania López Hernández, Marina Caparó Ferré, Albert Salas-Huetos, Isabel Salvat Salvat, Cristina Adillón Camón

Background and purpose: Action observation (AO) generates motor simulations in the brain, activating areas involved in actual movement and facilitating imitation. This randomized controlled trial aimed to analyze if observing actions performed by a personally selected referent improves balance in asymptomatic individuals compared to observing a standard referent.

Methods: A total of 165 healthy participants were randomized into three groups: a control group observing landscape videos, a standard referent group observing an unidentifiable model, and a chosen referent group selecting models based on personal similarity. Balance (static and dynamic) and strength were assessed at baseline, immediately post-intervention, at 15 days, and at 4 weeks. AO exercises related to balance were viewed three times per week for four weeks.

Results: Key findings revealed favorable changes in static balance for both the standard and chosen referent groups, particularly in challenging single-leg stances with eyes closed. Strength improvements were observed only in the standard referent group. Average adherence to the protocol was 91%.

Conclusion: AO enhances balance and strength in healthy individuals, with referent characteristics significantly impacting outcomes. The findings suggest referent selection is a crucial factor in AO's efficacy, emphasizing AO's therapeutic potential, particularly for populations with mobility challenges. Further research should refine referent selection to optimize clinical results.

{"title":"Influence of Referent selection on Balance in Action Observation: A Randomized Controlled Trial.","authors":"Tania López Hernández, Marina Caparó Ferré, Albert Salas-Huetos, Isabel Salvat Salvat, Cristina Adillón Camón","doi":"10.1016/j.ctim.2025.103150","DOIUrl":"https://doi.org/10.1016/j.ctim.2025.103150","url":null,"abstract":"<p><strong>Background and purpose: </strong>Action observation (AO) generates motor simulations in the brain, activating areas involved in actual movement and facilitating imitation. This randomized controlled trial aimed to analyze if observing actions performed by a personally selected referent improves balance in asymptomatic individuals compared to observing a standard referent.</p><p><strong>Methods: </strong>A total of 165 healthy participants were randomized into three groups: a control group observing landscape videos, a standard referent group observing an unidentifiable model, and a chosen referent group selecting models based on personal similarity. Balance (static and dynamic) and strength were assessed at baseline, immediately post-intervention, at 15 days, and at 4 weeks. AO exercises related to balance were viewed three times per week for four weeks.</p><p><strong>Results: </strong>Key findings revealed favorable changes in static balance for both the standard and chosen referent groups, particularly in challenging single-leg stances with eyes closed. Strength improvements were observed only in the standard referent group. Average adherence to the protocol was 91%.</p><p><strong>Conclusion: </strong>AO enhances balance and strength in healthy individuals, with referent characteristics significantly impacting outcomes. The findings suggest referent selection is a crucial factor in AO's efficacy, emphasizing AO's therapeutic potential, particularly for populations with mobility challenges. Further research should refine referent selection to optimize clinical results.</p>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":" ","pages":"103150"},"PeriodicalIF":3.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of acupuncture on patients with chronic obstructive pulmonary disease: A multicenter randomized controlled trial

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-14 DOI: 10.1016/j.ctim.2025.103146

Jiansheng Li , Yang Xie , Yanjun Wang , Lei Wu , Xuefeng Yu , Li Bai , Suju Shao , Miao Zhou , Mingli Zhang , Xueqing Yu , Weihong Han , Xuanlin Li , Tao Chen

Background

Chronic obstructive pulmonary disease (COPD) is a common and frequently occurring disease that seriously endangers health, causing a heavy economic burden on patients and society. Acupuncture has been reported to have a therapeutic effect on patients with chronic obstructive pulmonary disease (COPD). However, compared with medications, it is difficult to identify a superior therapy. Therefore, the aim of this study was to evaluate the efficacy and safety of acupuncture, conventional drug and acupuncture plus conventional drug in the treatment of COPD.

Methods

This was a multicenter, open-label randomized controlled trial (RCT) through a central randomization system. A total of 150 COPD patients were randomly assigned at a 1:1:1 ratio to the acupuncture group, conventional drug group or acupuncture plus conventional drug group for 12 weeks of treatment, followed by 12 weeks of untreated follow-up. The primary outcomes included the six-minute walk distance (6MWD) and St. George’s Respiratory Questionnaire (SGRQ), and the secondary outcomes included the modified Medical Research Council dyspnea scale (mMRC), acute exacerbation, lung function, and quality of life (COPD assessment test). Statistical analysis was conducted via SPSS software (version 26.0).

Results

A total of 150 patients were included in the study, and 143 patients completed the trial. There were time effects, group effects and interaction effects in the three groups (P < 0.05). Compared with that in the conventional drug group, the 6MWD in the acupuncture plus conventional drug group increased significantly at 4, 8, and 12 weeks of treatment and at 12 weeks of follow-up. The difference was statistically significant (P < 0.05). The symptom scores, motor scores, impact scores and total SGRQ scores at different time points in the three groups tended to change with time, with a time effect (P < 0.05), and there was no group or interaction effect (P > 0.05). Among the secondary outcomes, there were time effects on the number of acute exacerbations, forced expiratory volume in one second (FEV1) and forced expiratory volume in one second/forced vital capacity (FEV1/FVC) at different time points in the three groups (P < 0.05). mMRC had time and group effects (P < 0.05). CAT had time effects, group effects and interaction effects (P < 0.05).

Conclusions

Compared with the acupuncture group and the conventional drug group, the acupuncture plus conventional drug group was better at improving exercise ability, improving quality of life, and reducing dyspnea. It is safe and effective for the treatment of chronic obstructive pulmonary disease in the stable period, which can provide a reference for further related research.

Trial registration:

ClinicalTrials.gov, NCT03169504. Registered on 30 May 2017.

{"title":"Effect of acupuncture on patients with chronic obstructive pulmonary disease: A multicenter randomized controlled trial","authors":"Jiansheng Li , Yang Xie , Yanjun Wang , Lei Wu , Xuefeng Yu , Li Bai , Suju Shao , Miao Zhou , Mingli Zhang , Xueqing Yu , Weihong Han , Xuanlin Li , Tao Chen","doi":"10.1016/j.ctim.2025.103146","DOIUrl":"10.1016/j.ctim.2025.103146","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) is a common and frequently occurring disease that seriously endangers health, causing a heavy economic burden on patients and society. Acupuncture has been reported to have a therapeutic effect on patients with chronic obstructive pulmonary disease (COPD). However, compared with medications, it is difficult to identify a superior therapy. Therefore, the aim of this study was to evaluate the efficacy and safety of acupuncture, conventional drug and acupuncture plus conventional drug in the treatment of COPD.</div></div><div><h3>Methods</h3><div>This was a multicenter, open-label randomized controlled trial (RCT) through a central randomization system. A total of 150 COPD patients were randomly assigned at a 1:1:1 ratio to the acupuncture group, conventional drug group or acupuncture plus conventional drug group for 12 weeks of treatment, followed by 12 weeks of untreated follow-up. The primary outcomes included the six-minute walk distance (6MWD) and St. George’s Respiratory Questionnaire (SGRQ), and the secondary outcomes included the modified Medical Research Council dyspnea scale (mMRC), acute exacerbation, lung function, and quality of life (COPD assessment test). Statistical analysis was conducted via SPSS software (version 26.0).</div></div><div><h3>Results</h3><div>A total of 150 patients were included in the study, and 143 patients completed the trial. There were time effects, group effects and interaction effects in the three groups (P < 0.05). Compared with that in the conventional drug group, the 6MWD in the acupuncture plus conventional drug group increased significantly at 4, 8, and 12 weeks of treatment and at 12 weeks of follow-up. The difference was statistically significant (P < 0.05). The symptom scores, motor scores, impact scores and total SGRQ scores at different time points in the three groups tended to change with time, with a time effect (P < 0.05), and there was no group or interaction effect (P > 0.05). Among the secondary outcomes, there were time effects on the number of acute exacerbations, forced expiratory volume in one second (FEV1) and forced expiratory volume in one second/forced vital capacity (FEV1/FVC) at different time points in the three groups (P < 0.05). mMRC had time and group effects (P < 0.05). CAT had time effects, group effects and interaction effects (P < 0.05).</div></div><div><h3>Conclusions</h3><div>Compared with the acupuncture group and the conventional drug group, the acupuncture plus conventional drug group was better at improving exercise ability, improving quality of life, and reducing dyspnea. It is safe and effective for the treatment of chronic obstructive pulmonary disease in the stable period, which can provide a reference for further related research.</div><div><strong>Trial registration:</strong></div><div>ClinicalTrials.gov, NCT03169504. Registered on 30 May 2017.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103146"},"PeriodicalIF":3.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects and optimal dosage of traditional Chinese exercises on patients with chronic ankle instability: A systematic review and meta-analysis

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-12 DOI: 10.1016/j.ctim.2025.103145

Yikun Yin , Qihan Lin , Yongsheng Liu

Background

The effectiveness of Traditional Chinese exercises in promoting functional recovery in patients with chronic ankle instability, as well as the potential impact of variables such as intervention type, duration, frequency, and cycle on treatment outcomes, still requires further investigation.

Methods

Literature searches were conducted in multiple databases including China National Knowledge Infrastructure (CNKI), VIP, Wanfang, China Biomedical Literature Database (CBM), PubMed, EBSCO(Medline、CINAHL、SPORTDiscus), Embase, Cochrane Library, ProQuest, and Web of Science for randomized controlled trials assessing the effects of Traditional Chinese Exercises interventions on patients with Chronic Ankle Instability. The publication timeframe spanned from the inception of each database until January 20, 2025. Meta-analysis was performed using STATA 15 software on the included studies.

Results

Twelve randomized controlled trials (RCTs) involving 323 patients were included in this analysis. Compared with the control group, Traditional Chinese exercises showed the following improvements: CAIT: WMD = 4.02, 95 % CI [3.22, 4.81], z = 9.90, P < 0.001.Balance: ANT: SMD = 0.38, 95 % CI [0.18, 0.59], z = 3.71, P = 0.003.PM: SMD = 0.49, 95 % CI [0.26, 0.70], z = 4.73, P < 0.001.PL: SMD = 0.67, 95 % CI [0.46, 0.88], z = 6.35, P < 0.001.C: SMD = 0.80, 95 % CI [0.35, 1.25], z = 3.51, P < 0.001.JPS:Plantarflexion: SMD = -0.58, 95 % CI [-0.94, −0.21], z = 3.09, P = 0.002.Inversion: SMD = -0.46, 95 % CI [-0.86, −0.06], z = 2.23, P = 0.025.Muscle Strength: Plantarflexion: SMD = 0.81, 95 % CI [0.43, 1.18], z = 4.25, P < 0.001.Inversion: SMD = 0.66, 95 % CI [0.25, 1.07], z = 3.16, P = 0.002.Eversion: SMD = 1.04, 95 % CI [0.62, 1.46], z = 4.82, P < 0.001.Subgroup Analysis: Tai Chi training conducted twice weekly for a 12-week intervention period, with 60-minute sessions, demonstrated the most effective improvements. Level of Evidence: The evidence level for the effects of Traditional Chinese exercises on Balance-ANT, Balance-PM, and Balance-PL balance directions in CAI patients is rated as "moderate."

Conclusion

Traditional Chinese exercise has been shown to significantly improve balance, muscle strength, and joint position sense in CAI patients. Based on the current findings, Tai Chi training appears to provide greater benefits for CAI patients. It is recommended that CAI patients participate in Tai Chi training twice a week, with each session lasting 60 minutes, over a 12-week period.

Systematic review registration

PROSPERO database, CRD42024613359.

{"title":"The effects and optimal dosage of traditional Chinese exercises on patients with chronic ankle instability: A systematic review and meta-analysis","authors":"Yikun Yin , Qihan Lin , Yongsheng Liu","doi":"10.1016/j.ctim.2025.103145","DOIUrl":"10.1016/j.ctim.2025.103145","url":null,"abstract":"<div><h3>Background</h3><div>The effectiveness of Traditional Chinese exercises in promoting functional recovery in patients with chronic ankle instability, as well as the potential impact of variables such as intervention type, duration, frequency, and cycle on treatment outcomes, still requires further investigation.</div></div><div><h3>Methods</h3><div>Literature searches were conducted in multiple databases including China National Knowledge Infrastructure (CNKI), VIP, Wanfang, China Biomedical Literature Database (CBM), PubMed, EBSCO(Medline、CINAHL、SPORTDiscus), Embase, Cochrane Library, ProQuest, and Web of Science for randomized controlled trials assessing the effects of Traditional Chinese Exercises interventions on patients with Chronic Ankle Instability. The publication timeframe spanned from the inception of each database until January 20, 2025. Meta-analysis was performed using STATA 15 software on the included studies.</div></div><div><h3>Results</h3><div>Twelve randomized controlled trials (RCTs) involving 323 patients were included in this analysis. Compared with the control group, Traditional Chinese exercises showed the following improvements: CAIT: WMD = 4.02, 95 % CI [3.22, 4.81], z = 9.90, P < 0.001.Balance: ANT: SMD = 0.38, 95 % CI [0.18, 0.59], z = 3.71, P = 0.003.PM: SMD = 0.49, 95 % CI [0.26, 0.70], z = 4.73, P < 0.001.PL: SMD = 0.67, 95 % CI [0.46, 0.88], z = 6.35, P < 0.001.C: SMD = 0.80, 95 % CI [0.35, 1.25], z = 3.51, P < 0.001.JPS:Plantarflexion: SMD = -0.58, 95 % CI [-0.94, −0.21], z = 3.09, P = 0.002.Inversion: SMD = -0.46, 95 % CI [-0.86, −0.06], z = 2.23, P = 0.025.Muscle Strength: Plantarflexion: SMD = 0.81, 95 % CI [0.43, 1.18], z = 4.25, P < 0.001.Inversion: SMD = 0.66, 95 % CI [0.25, 1.07], z = 3.16, P = 0.002.Eversion: SMD = 1.04, 95 % CI [0.62, 1.46], z = 4.82, P < 0.001.Subgroup Analysis: Tai Chi training conducted twice weekly for a 12-week intervention period, with 60-minute sessions, demonstrated the most effective improvements. Level of Evidence: The evidence level for the effects of Traditional Chinese exercises on Balance-ANT, Balance-PM, and Balance-PL balance directions in CAI patients is rated as \"moderate.\"</div></div><div><h3>Conclusion</h3><div>Traditional Chinese exercise has been shown to significantly improve balance, muscle strength, and joint position sense in CAI patients. Based on the current findings, Tai Chi training appears to provide greater benefits for CAI patients. It is recommended that CAI patients participate in Tai Chi training twice a week, with each session lasting 60 minutes, over a 12-week period.</div></div><div><h3>Systematic review registration</h3><div>PROSPERO database, CRD42024613359.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103145"},"PeriodicalIF":3.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative efficacy of acupuncture therapies in premature ovarian failure: A systematic review and network meta-analysis

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-07 DOI: 10.1016/j.ctim.2025.103141

Yonghang Yi, Fengjun Ma, Yang Jiao, Rongqi Zhang, Yunhao Yi, Yuxia Ma

Objectives

Premature ovarian failure (POF) is becoming more common and has a major negative impact on women's mental and physical well-being. The use of acupuncture therapies to treat POF has gained popularity. However, the optimal treatment remains uncertain. This study aimed to systematically review the literature and conduct a network meta-analysis (NMA) to compare the efficacy of different acupuncture and related therapies and identify methodologic weaknesses in previous studies.

Design

We systematically searched six databases from their inception to April 2024 for randomized controlled trials (RCTs) of acupuncture therapies for POF. We assessed methodological quality and risk of bias using the RoB 2.0 tool. The NMA was conducted using R and STATA software based on frequency theory, focusing on overall effectiveness rates and hormone levels. Additionally, we critically reviewed methodological limitations and potential biases in the studies included.

Results

Thirty-seven eligible studies involving 2419 patients were included in this NMA. The NMA results indicated that moxibustion_catgut implantation at acupoint (MB_CIA) (P-score = 0.88; pooled mean difference (95 % CI): 22.07 (1.61–302.48)) showed the highest improvement in overall effectiveness, while warming acupuncture (WA) (0.95; −27.56 (-45.35 to −9.78)) improved follicle-stimulating hormone (FSH) levels best. WA_MB (0.85; −9.35 (-15.08 to −3.62)) and WA (P-score = 0.77) were most effective for luteinizing hormone (LH) and estradiol (E2) levels, respectively. Confidence in evidence ranged from moderate to very low, with low overall confidence. Key methodologic weaknesses included insufficient allocation concealment, lack of blinding, and small sample sizes.

Conclusions

Acupuncture therapies may effectively improve POF. MB_CIA, WA, and WA_MB seem to be the most effective. However, severe methodological constraints, such as insufficient randomization and a lack of blinding, may reduce trust in these results. To offer robust evidence, high-quality RCTs must overcome these limitations.

Systematic review registration

[PROSPERO], identifier [CRD42024550180].

{"title":"Comparative efficacy of acupuncture therapies in premature ovarian failure: A systematic review and network meta-analysis","authors":"Yonghang Yi, Fengjun Ma, Yang Jiao, Rongqi Zhang, Yunhao Yi, Yuxia Ma","doi":"10.1016/j.ctim.2025.103141","DOIUrl":"10.1016/j.ctim.2025.103141","url":null,"abstract":"<div><h3>Objectives</h3><div>Premature ovarian failure (POF) is becoming more common and has a major negative impact on women's mental and physical well-being. The use of acupuncture therapies to treat POF has gained popularity. However, the optimal treatment remains uncertain. This study aimed to systematically review the literature and conduct a network meta-analysis (NMA) to compare the efficacy of different acupuncture and related therapies and identify methodologic weaknesses in previous studies.</div></div><div><h3>Design</h3><div>We systematically searched six databases from their inception to April 2024 for randomized controlled trials (RCTs) of acupuncture therapies for POF. We assessed methodological quality and risk of bias using the RoB 2.0 tool. The NMA was conducted using R and STATA software based on frequency theory, focusing on overall effectiveness rates and hormone levels. Additionally, we critically reviewed methodological limitations and potential biases in the studies included.</div></div><div><h3>Results</h3><div>Thirty-seven eligible studies involving 2419 patients were included in this NMA. The NMA results indicated that moxibustion_catgut implantation at acupoint (MB_CIA) (P-score = 0.88; pooled mean difference (95 % CI): 22.07 (1.61–302.48)) showed the highest improvement in overall effectiveness, while warming acupuncture (WA) (0.95; −27.56 (-45.35 to −9.78)) improved follicle-stimulating hormone (FSH) levels best. WA_MB (0.85; −9.35 (-15.08 to −3.62)) and WA (P-score = 0.77) were most effective for luteinizing hormone (LH) and estradiol (E2) levels, respectively. Confidence in evidence ranged from moderate to very low, with low overall confidence. Key methodologic weaknesses included insufficient allocation concealment, lack of blinding, and small sample sizes.</div></div><div><h3>Conclusions</h3><div>Acupuncture therapies may effectively improve POF. MB_CIA, WA, and WA_MB seem to be the most effective. However, severe methodological constraints, such as insufficient randomization and a lack of blinding, may reduce trust in these results. To offer robust evidence, high-quality RCTs must overcome these limitations.</div></div><div><h3>Systematic review registration</h3><div>[PROSPERO], identifier [CRD42024550180].</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103141"},"PeriodicalIF":3.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to Editor on “Tuina versus physiotherapy or a combination of both for the management of chronic nonspecific low back pain: A randomized controlled trial”

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-07 DOI: 10.1016/j.ctim.2025.103140

Swarup Ghosh, Krishnagopal Mondal

引用次数: 0

Response to Letter to Editor on “Tuina versus physiotherapy or a combination of both for the management of chronic nonspecific low back pain: A randomized controlled trial”

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine

Pub Date : 2025-02-05 DOI: 10.1016/j.ctim.2025.103143

Qinqyu Ma, Jiaxu Chen

引用次数: 0