Tai chi has been used to treat different forms of osteoporosis and increase bone density without the use of pharmaceuticals.
The purpose of this study was to use bibliometric analysis to methodically examine trends and hotspots of tai chi treatment for osteoporosis in order to generate references for further investigation.
The articles on Tai Chi to treat osteoporosis was obtained from China National Knowledge Infrastructure (CNKI), Wan Fang, Web of Science (WOS) and PubMed between inception and November 8,2023. The annual publication volume, authors, institutions, and keywords, along with co-citation, clustering, and burst analysis, were analyzed using CiteSpace.
Totally, 328 publications were included. The number of annual publications has been rising rapidly in recent years. Beijing University of Chinese Medicine and Shanghai University of Sport are two of the best universities for Tai Chi treatment in osteoporosis. This area of research is dominated by Zhou, Y; Yu, DH; Pence, BC and Qin,L. Core authors and core institutions having a relatively low level of collaboration indicates that there may be limited interaction and cooperation between these key players in the field. China had the highest volume of publications, followed by the United States. Furthermore, the majority of the study subjects and influence mechanism are the focus of current research in this field.
Tai Chi in osteoporosis research field is in a stage of stable development. Universities and higher education institutions are the leading institutions in this field. China and the United States emerging as high productivity nations. The study of Tai Chi in osteoporosis not only focuses on the applicable population, effects and intervention methods, but also gradually shifts to the mechanism study such as “secretion of beneficial factors”, “physical exercise load” and “oxidative stress status”.
Hypertension is a leading contributor to cardiovascular disorders globally. There has been a recent upsurge in non-pharmacological management involving mindfulness-based meditation (MBM) in lowering blood pressure (BP) among the hypertensive population; however, the level of supportive evidence among patients primarily diagnosed with hypertension remain limited. Therefore, this systematic review aimed to synthesize the evidence of randomized controlled trials (RCTs) on the effect of MBM on BP explicitly in adults primarily diagnosed with elevated blood pressure or hypertension.
A database search of RCTs was conducted in PubMed, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science until December 2023. The effect size score was calculated for variables of interest followed by qualitative analysis.
Nine studies with 543 participants (mean age 54.9±9.0) met the pre-specified eligibility criteria. Eight trials reported MBM convincing in lowering the systolic BP (p=0.001–0.020) and 6 in reducing the diastolic BP (p=0.001–0.01) among this target population. There was a disparity of gender in 7 studies and 4 trials did not report the ethnicity of participants. The methodological quality of the trials was gratifying, however, most studies presented with absence of allocation concealment and blinding of outcome assessors, fragmentary reporting of data, and high attrition rate that potentially affected the validity of trials.
MBM interventions may serve as an early preventive and supportive measure for adults with elevated BP or hypertension. However, more robust and rigorous trials with a larger, homogeneous sample and long-term follow-up are necessary to quantify the magnitude of this intervention. Moreover, the methodological issues may affect the overall quality and reliability of MBM interventions; hence, future studies must also address the risk of bias due to inadequate blinding and high attrition through treatment concealment and personalized engagement measures.
This meta-analysis aimed to explore the relationship between the dose of acupuncture sessions, acupuncture frequency, and acupuncture duration and its effects on migraine.
Eight databases were searched for randomized controlled trials (RCTs) evaluating the efficacy of penetrating manual acupuncture for migraine published in English and Chinese from inception to June 20, 2024. The robust-error meta-regression (REMR) approach and non-linear meta-regression with restricted cubic spline (RCS) were used to investigate the dose-response association between acupuncture sessions, acupuncture frequency, and acupuncture duration and the frequency of migraine attacks. The potential nonlinear relationships was tested by restricting the regression coefficient to zero and a P value<0.1. The statistical analysis was conducted using Stata 17.0. The risk of bias was independently assessed by two reviewers using the Cochrane tool. The reporting quality for acupuncture procedures was evaluated by STRICTA criteria.
Thirty-two RCTs involving 1562 participants were included, and the results showed a J-shaped dose-response association between acupuncture sessions, acupuncture frequency, and acupuncture duration and migraine attack frequency. After 16 acupuncture sessions, the change in the frequency of migraine attacks was 3.95 (95 %CI: 3.13 to 4.77). Three sessions of acupuncture a week resulted in a significant decrease in the frequency of migraine attacks, reaching 4.04 (95 % CI: 2.49 to 5.58). After two months of acupuncture, the frequency of migraine attacks decreased significantly, showing a difference of 4.05 (95 % CI: 3.61 to 4.49). Subsequently, the improvement trend gradually flattened, yielding diminishing benefits to patients. The risk of bias showed that seven studies were rated as “low risk”, two were rated as “high risk”, and the others were rated as “unclear risk”. The reporting quality of RCTs of acupuncture for migraine remain suboptimal.
A non-linear dose-response relationship was found between acupuncture sessions, acupuncture frequency, and acupuncture duration and migraine attack frequency. The results of our study recommend 16 sessions of acupuncture with a frequency of 3 sessions/week and a treatment duration of 1.5 to 2 months.
This meta-analysis has been registered on PROSPERO (CRD42023400493).