Effects of aerobic exercise on cognitive function in adults with major depressive disorder: A systematic review and meta-analysis

IF 5.3 1区 心理学 Q1 PSYCHOLOGY, CLINICAL International Journal of Clinical and Health Psychology Pub Date : 2024-02-09 DOI:10.1016/j.ijchp.2024.100447
Fei-Fei Ren , Charles H. Hillman , Wei-Guang Wang , Ruei-Hong Li , Wen-Sheng Zhou , Wen-Ming Liang , Yong Yang , Feng-Tzu Chen , Yu-Kai Chang
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Abstract

Background

Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder that impairs the cognitive function of individuals. Aerobic exercise stands out as a promising non-pharmacological intervention for enhancing cognitive function and promoting brain health.

While positive impacts of aerobic exercise on executive function in adults with depression have been documented, a comprehensive understanding of its benefits on overall cognitive function, including memory, attention, and processing speed, along with key moderating factors in adults with MDD, remains unexplored. The purpose of the systematic review and meta-analysis was to investigate the effects of aerobic exercise on overall cognitive function in adults with MDD, and to explore whether cognitive sub-domains, aerobic exercise characteristics, and study and sample variables modify the effects of aerobic exercise on cognition.

Methods

Six English electronic databases (Embase, Cochrane Central, Scopus, APA PsycInfo, PubMed, Web of Science) were searched from inception to 2 April 2023. Randomized trials, including adults aged 18 years or above with a diagnosis of clinical depression, of the effects of aerobic exercise on cognitive function in adults with MDD compared to non-aerobic exercise groups were included. A three-level meta-analysis was conducted utilizing a random-effects model in R. The quality of the studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale. The PROSPERO registration number is CRD42022367350.

Results

Twelve randomized trials including 945 adults with MDD were included. Results indicated that aerobic exercise significantly improved overall cognitive function (g = 0.21; 95 % confidence intervals [CI] = 0.07, 0.34), and the sub-domains of memory (g = 0.25; 95 % CI = 0.06, 0.44) and executive function (g = 0.12; 95 % CI = 0.04, 0.20). Significant benefits in cognitive function were found from moderate-to-vigorous (mixed) intensity (g = 0.19; 95 % CI = 0.02, 0.37), aerobic exercise conducted 3 times per week (g = 0.23; 95 % CI = 0.10, 0.38), in sessions < 45 min (g = 0.59; 95 % CI = 0.28, 0.90), and 45–60 min (g = 0.16; 95 % CI = 0.07, 0.26), in aerobic exercise intervention ≤ 12 weeks (g = 0. 26; 95 % CI = 0.08, 0.44).

Limitations

This review only included peer-reviewed English-language studies, which may lead to a language bias. The results of the Egger's test suggested a potential publication bias.

Conclusions

Aerobic exercise is efficacious in improving overall cognitive function and the sub-domains of memory and executive function in adults with major depressive disorder.

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有氧运动对重度抑郁症成人认知功能的影响:系统回顾与荟萃分析
背景重度抑郁症(MDD)是一种高发的精神疾病,会损害患者的认知功能。有氧运动是增强认知功能和促进大脑健康的一种很有前景的非药物干预措施。虽然有文献记载了有氧运动对成人抑郁症患者的执行功能有积极影响,但对其对整体认知功能(包括记忆力、注意力和处理速度)的益处以及对成人 MDD 患者的关键调节因素的全面了解仍有待探索。本系统综述和荟萃分析旨在研究有氧运动对患有 MDD 的成人整体认知功能的影响,并探讨认知子领域、有氧运动特征以及研究和样本变量是否会改变有氧运动对认知的影响。纳入的随机试验包括年龄在 18 岁或以上、诊断为临床抑郁症的成人,与非有氧运动组相比,有氧运动对患有 MDD 的成人认知功能的影响。研究质量采用物理治疗证据数据库(PEDro)量表进行评估。PROSPERO注册号为CRD42022367350。结果纳入了12项随机试验,包括945名患有MDD的成人患者。结果表明,有氧运动能明显改善整体认知功能(g = 0.21;95 % 置信区间 [CI] = 0.07,0.34)、记忆子域(g = 0.25;95 % CI = 0.06,0.44)和执行功能(g = 0.12;95 % CI = 0.04,0.20)。每周 3 次(g = 0.23;95 % CI = 0.10,0.38)、每次 45 分钟(g = 0.59;95 % CI = 0.限制本综述只纳入了同行评审的英语研究,这可能会导致语言偏差。结论有氧运动能有效改善重度抑郁障碍成人的整体认知功能以及记忆和执行功能的子领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.70
自引率
5.70%
发文量
38
审稿时长
33 days
期刊介绍: The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.
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