{"title":"Analysis of the relationship between comorbid obstructive sleep apnea and clinical outcomes in patients with asthma in Japan","authors":"Hitomi Ikegami-Tanaka, Naoya Yasokawa, Koji Kurose, Shonosuke Tajima, Masaaki Abe, Shigeki Katoh, Yoshihiro Kobashi, Toru Oga","doi":"10.1016/j.alit.2024.01.009","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Asthma and obstructive sleep apnea (OSA) are prevalent chronic respiratory disorders, which often coexist and interact with each other. Obesity is an important risk factor shared by them. The rate of obesity is lower in Japan versus Western countries. Hence, the co-existence of asthma and OSA has not been investigated in Japan.</p></div><div><h3>Methods</h3><p>Ninety-seven outpatients with asthma were recruited. Patients wore a portable monitor for sleep study. Background data, pulmonary function, blood tests, and patient-reported outcomes including gastroesophageal reflux disease, sleepiness, sleep quality, asthma control, cough and respiratory symptoms, and health status, were assessed.</p></div><div><h3>Results</h3><p>Of the patients, 19 (19.6 %), 40 (41.2 %), 24 (24.7 %), and 14 (14.4 %) were classified into non-, mild, moderate, and severe OSA groups. Non-OSA patients were younger than those in other groups (p < 0.05). The BMI of patients with moderate and severe OSA, was higher than that of non-OSA patients (p < 0.05). Pulmonary function, FeNO, serum IgE, and the number of peripheral eosinophils were not significantly different between groups. Nonetheless, compared with the other groups, treatment step was the highest, and the Asthma Control Test, Leicester Cough Questionnaire, COPD Assessment Test, and Asthma Health Questionnaire-33 yielded worst scores in the severe OSA group, and predicted the severe OSA after adjustment by BMI.</p></div><div><h3>Conclusions</h3><p>Moderate and severe OSA are highly prevalent among patients with asthma in Japan. Pulmonary function did not differ between groups. However, patients with asthma and severe OSA were linked to more asthma treatment, worse asthma control, more symptoms and cough, and worse health status.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 390-396"},"PeriodicalIF":6.2000,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000108/pdfft?md5=7b59586cb4bbcbcbc84e83ee54e67e81&pid=1-s2.0-S1323893024000108-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergology International","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1323893024000108","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
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Abstract
Background
Asthma and obstructive sleep apnea (OSA) are prevalent chronic respiratory disorders, which often coexist and interact with each other. Obesity is an important risk factor shared by them. The rate of obesity is lower in Japan versus Western countries. Hence, the co-existence of asthma and OSA has not been investigated in Japan.
Methods
Ninety-seven outpatients with asthma were recruited. Patients wore a portable monitor for sleep study. Background data, pulmonary function, blood tests, and patient-reported outcomes including gastroesophageal reflux disease, sleepiness, sleep quality, asthma control, cough and respiratory symptoms, and health status, were assessed.
Results
Of the patients, 19 (19.6 %), 40 (41.2 %), 24 (24.7 %), and 14 (14.4 %) were classified into non-, mild, moderate, and severe OSA groups. Non-OSA patients were younger than those in other groups (p < 0.05). The BMI of patients with moderate and severe OSA, was higher than that of non-OSA patients (p < 0.05). Pulmonary function, FeNO, serum IgE, and the number of peripheral eosinophils were not significantly different between groups. Nonetheless, compared with the other groups, treatment step was the highest, and the Asthma Control Test, Leicester Cough Questionnaire, COPD Assessment Test, and Asthma Health Questionnaire-33 yielded worst scores in the severe OSA group, and predicted the severe OSA after adjustment by BMI.
Conclusions
Moderate and severe OSA are highly prevalent among patients with asthma in Japan. Pulmonary function did not differ between groups. However, patients with asthma and severe OSA were linked to more asthma treatment, worse asthma control, more symptoms and cough, and worse health status.
背景:哮喘和阻塞性睡眠呼吸暂停(OSA)是普遍存在的慢性呼吸系统疾病,两者常常同时存在并相互影响。肥胖是它们共同的重要风险因素。与西方国家相比,日本的肥胖率较低。因此,日本尚未对哮喘和 OSA 同时存在的情况进行调查:方法:招募了 97 名门诊哮喘患者。患者佩戴便携式监测仪进行睡眠研究。对患者的背景数据、肺功能、血液检查和患者报告的结果(包括胃食管反流病、嗜睡、睡眠质量、哮喘控制、咳嗽和呼吸道症状以及健康状况)进行了评估:患者中,19 人(19.6%)、40 人(41.2%)、24 人(24.7%)和 14 人(14.4%)被分为非、轻度、中度和重度 OSA 组。与其他组别相比,非 OSA 患者更年轻(P中度和重度 OSA 在日本哮喘患者中发病率很高。各组之间的肺功能没有差异。但是,哮喘和重度 OSA 患者需要接受更多的哮喘治疗、哮喘控制能力更差、症状和咳嗽更多以及健康状况更差。
期刊介绍:
Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense.
The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.