Developmental Assessment in Neonatal Hypernatremic Dehydration Cohort at 18-30 months of Age Using DASII Score.

IF 2.1 4区 医学 Q2 PEDIATRICS Indian Journal of Pediatrics Pub Date : 2024-12-01 Epub Date: 2024-02-12 DOI:10.1007/s12098-024-05044-x
Damini Sharma, Anurag Singh, Arushi Singhal, Arushi Singh, Adhiraj Singh
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Abstract

Developmental assessment of neonatal hypernatremic dehydration cohort was done at 18-30 mo of age using Developmental Assessment Scale for Indian Infants (DASII) score in relation to brain lesions detected on brain imaging. Long-term follow-up evaluations were performed in 45 out of initial cohort of neonatal hypernatremic dehydration and compared with 45 controls with normal sodium levels. Seven percent of infants in the study group had a delay in development at 24 mo of age. The severity of hypernatremia was strongly correlated with poor developmental outcome at 24 mo (p = 0.001). Abnormal magnetic resonance imaging patterns strongly correlated with poor developmental outcome at 24 mo (p = 0.001). Brain was found to be particularly vulnerable to the effects of hypernatremic dehydration in neonates with brain imaging showing brain changes which presented with developmental delay on follow-up. Motor score was found to be more severely affected than mental facet using DASII score.

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使用 DASII 评分对 18-30 个月大的新生儿高钠血症脱水队列进行发育评估。
使用印度婴儿发育评估量表(DASII)评分,结合脑成像检测到的脑部病变,对新生儿高钠血症脱水人群在18-30个月大时的发育情况进行评估。在最初的新生儿高钠脱水组群中,对 45 名婴儿进行了长期随访评估,并与 45 名钠水平正常的对照组进行了比较。研究组中有 7% 的婴儿在 24 个月大时发育迟缓。高钠血症的严重程度与24个月时的发育不良结果密切相关(p = 0.001)。异常的磁共振成像模式与 24 个月时的不良发育结果密切相关(p = 0.001)。研究发现,新生儿的大脑特别容易受到高钠血症脱水的影响,脑成像显示其大脑发生变化,并在随访时出现发育迟缓。通过 DASII 评分发现,运动评分比智力评分受到的影响更严重。
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来源期刊
Indian Journal of Pediatrics
Indian Journal of Pediatrics 医学-小儿科
CiteScore
8.10
自引率
7.00%
发文量
394
审稿时长
3-6 weeks
期刊介绍: Indian Journal of Pediatrics (IJP), is an official publication of the Dr. K.C. Chaudhuri Foundation. The Journal, a peer-reviewed publication, is published twelve times a year on a monthly basis (January, February, March, April, May, June, July, August, September, October, November, December), and publishes clinical and basic research of all aspects of pediatrics, provided they have scientific merit and represent an important advance in knowledge. The Journal publishes original articles, review articles, case reports which provide new information, letters in relation to published articles, scientific research letters and picture of the month, announcements (meetings, courses, job advertisements); summary report of conferences and book reviews.
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