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Indian Journal of Pediatrics最新文献

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Severe Vitamin D Deficiency Mimicking Bone Tumor in an Adolescent: Correspondence. 青少年严重维生素D缺乏模拟骨肿瘤：对应。
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-19 DOI: 10.1007/s12098-025-05909-9
Chang-Yong Chen, Kai-Wei Zhang
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引用次数: 0
An Outbreak of Vitamin D Toxicity Due to Erroneously Fortified Cooking Oil Consumption: Authors' Reply. 因误食强化食用油而引发的维生素D中毒事件：作者回复。
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-19 DOI: 10.1007/s12098-025-05908-w
Sharan Thangaraju, Devi Dayal
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引用次数: 0
Fine Motor Outcomes in Children with Guillain-Barré Syndrome. 格林-巴罗综合征患儿的精细运动预后。
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-19 DOI: 10.1007/s12098-025-05891-2
Ashna Kumar, Lokesh Saini, Pradeep Kumar Gunasekaran, Sarbesh Tiwari, Saurabh Agarwal, Rahul Gupta, Ashwini Chityala, Daisy Khera, Ravi Gaur, Jagdish Prasad Goyal, Kuldeep Singh

Objectives: To study the motor outcomes at 6-mo and 1-y follow-up of children with Guillain-Barré syndrome (GBS).

Methods: This study was an ambispective study of 12 mo duration including children with GBS. The motor outcomes were assessed using Hughes Guillain-Barré Syndrome Disability Score (GBSDS) and Overall Neuropathy Limitations Scale (ONLS) at discharge, 6-mo, and 1-y follow-up.

Results: Of 56 patients enrolled, 52 children were included in the study. The median (IQR) age at presentation was 8 (4-11) y. Acute motor axonal neuropathy (AMAN) was the most common variant (50%) in the study. At discharge, all the children had GBSDS ≥ 2, with 51.9% (27/52) patients at 6-mo follow-up, and 19.2% (10/52) had GBSDS ≥ 2 at 1-y follow-up, signifying the need for assistance. On ONLS assessment, 46.2% (24/52) had an arm score of > 2, and 86.5% (45/52) had a leg score of > 2 at discharge. At 6-mo follow-up, 26.9% (14/52) had an arm score > 2, and 19.2% (10/52) had a leg score > 2. At 1-y follow-up, 7.7% (4/52) had an arm score of > 2, and 9.7% (5/52) had a leg score > 2. There was no mortality in the index study.

Conclusions: Though most children with GBS recover completely, there can still be long-term impairments of fine motor movements required for daily activities. Early recognition and monitoring of persistent motor deficits as long-term sequelae of GBS is of utmost importance to improve the quality of life of these children.

目的：研究吉兰-巴勒综合征（GBS）患儿6个月及1年随访时的运动预后。方法：本研究是一项为期12个月的双视角研究，包括GBS患儿。在出院、6个月和1年随访时，使用休斯格林-巴勒综合征残疾评分（GBSDS）和整体神经病变限制量表（ONLS）评估运动结果。结果：56例入组患者中，52例儿童纳入研究。发病时的中位（IQR）年龄为8（4-11）岁。急性运动轴索神经病变（AMAN）是研究中最常见的变异（50%）。出院时，所有患儿的GBSDS≥2，随访6个月时51.9%(27/52)，随访1年时19.2%（10/52）患儿的GBSDS≥2，需要帮助。在ONLS评估中，46.2%（24/52）的患者出院时手臂评分为> 2,86.5%（45/52）的患者出院时腿部评分为> 2。在6个月的随访中，26.9%（14/52）的手臂评分为> 2,19.2%（10/52）的腿部评分为> 2。随访1年，7.7%（4/52）患者的手臂评分为> 2,9.7%（5/52）患者的腿部评分为> 2。在指数研究中没有死亡率。结论：虽然大多数GBS患儿完全康复，但仍可能存在日常活动所需的精细运动的长期损伤。早期识别和监测作为GBS长期后遗症的持续性运动缺陷对于改善这些儿童的生活质量至关重要。
{"title":"Fine Motor Outcomes in Children with Guillain-Barré Syndrome.","authors":"Ashna Kumar, Lokesh Saini, Pradeep Kumar Gunasekaran, Sarbesh Tiwari, Saurabh Agarwal, Rahul Gupta, Ashwini Chityala, Daisy Khera, Ravi Gaur, Jagdish Prasad Goyal, Kuldeep Singh","doi":"10.1007/s12098-025-05891-2","DOIUrl":"https://doi.org/10.1007/s12098-025-05891-2","url":null,"abstract":"<p><strong>Objectives: </strong>To study the motor outcomes at 6-mo and 1-y follow-up of children with Guillain-Barré syndrome (GBS).</p><p><strong>Methods: </strong>This study was an ambispective study of 12 mo duration including children with GBS. The motor outcomes were assessed using Hughes Guillain-Barré Syndrome Disability Score (GBSDS) and Overall Neuropathy Limitations Scale (ONLS) at discharge, 6-mo, and 1-y follow-up.</p><p><strong>Results: </strong>Of 56 patients enrolled, 52 children were included in the study. The median (IQR) age at presentation was 8 (4-11) y. Acute motor axonal neuropathy (AMAN) was the most common variant (50%) in the study. At discharge, all the children had GBSDS ≥ 2, with 51.9% (27/52) patients at 6-mo follow-up, and 19.2% (10/52) had GBSDS ≥ 2 at 1-y follow-up, signifying the need for assistance. On ONLS assessment, 46.2% (24/52) had an arm score of > 2, and 86.5% (45/52) had a leg score of > 2 at discharge. At 6-mo follow-up, 26.9% (14/52) had an arm score > 2, and 19.2% (10/52) had a leg score > 2. At 1-y follow-up, 7.7% (4/52) had an arm score of > 2, and 9.7% (5/52) had a leg score > 2. There was no mortality in the index study.</p><p><strong>Conclusions: </strong>Though most children with GBS recover completely, there can still be long-term impairments of fine motor movements required for daily activities. Early recognition and monitoring of persistent motor deficits as long-term sequelae of GBS is of utmost importance to improve the quality of life of these children.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomised Controlled Trial Comparing Single Maintenance and Reliever Therapy (SMART) with Inhaled Budesonide-Formoterol Combination, Versus Conventional Budesonide and Additional As-Needed Levo-Salbutamol, in Children with Persistent Bronchial Asthma. 比较吸入布地奈德-福莫特罗联合单次维持和缓解治疗（SMART）与常规布地奈德和额外的左旋沙丁胺醇治疗持续性支气管哮喘儿童的随机对照试验
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-17 DOI: 10.1007/s12098-025-05868-1
Annie Basson, Deepak Dhawan, Joseph L Mathew

Objectives: To compare the efficacy, safety and cost of Single Maintenance and Reliever Therapy (SMART) with low dose inhaled budesonide-formoterol combination vs. conventional budesonide plus as-needed levo-salbutamol, in 6-11-y-old children with asthma.

Methods: In this randomised controlled trial (RCT), 84 children (6-11 y) with treatment-naïve asthma were randomised to either SMART with inhaled budesonide-formoterol combination, or budesonide plus as-needed levo-salbutamol. Peak expiratory flow (PEF), asthma symptom score, number of rescue doses, exacerbations, adherence, inhalation technique, adverse events and cost were recorded over the first 12 wk of follow-up.

Results: Baseline PEF, asthma symptom score, and other characteristics were comparable. At the end of 12 wk, the median (IQR) improvement in PEF was 16% (10, 20) vs. 11% (8.5, 15.5), p = 0.01. The median (IQR) weekly asthma symptom score was 3 (2, 4.5) vs. 4 (3, 7), p = 0.02. The median (IQR) number of rescue doses were 0 (0, 0) vs. 4 (3, 6), p = 0.02. Only 9/37 (24.3%) vs. 16/37 (43.2%) children had exacerbations, p = 0.05. There were no adverse effects considered significant in either group. The total cost of treatment was lower with SMART.

Conclusions: SMART showed greater short-term efficacy and was less expensive compared to conventional therapy in 6-11 y-old asthmatic children, with no additional safety concerns.

目的：比较低剂量布地奈德-福莫特罗联合吸入单次维持和缓解治疗（SMART）与常规布地奈德加按需左旋沙丁胺醇治疗6-11岁哮喘儿童的疗效、安全性和成本。方法：在这项随机对照试验（RCT）中，84名患有treatment-naïve哮喘的儿童（6-11岁）被随机分为吸入布地奈德-福莫特罗联合SMART组，或布地奈德按需加左旋沙丁胺醇组。在随访的前12周记录呼气峰流量（PEF）、哮喘症状评分、抢救剂量、加重、依从性、吸入技术、不良事件和成本。结果：基线PEF、哮喘症状评分和其他特征具有可比性。在12周结束时，PEF的中位改善（IQR）为16%（10,20）对11% (8.5,15.5),p = 0.01。每周哮喘症状评分中位数（IQR）为3（2,4.5）比4 (3,7),p = 0.02。抢救剂量中位数（IQR）为0 (0,0)vs. 4 (3,6), p = 0.02。仅有9/37（24.3%）对16/37（43.2%）患儿出现加重，p = 0.05。两组均未发现明显的不良反应。SMART的总治疗费用较低。结论：与常规治疗相比，SMART在6-11岁哮喘儿童中表现出更高的短期疗效和更低的成本，没有额外的安全性问题。
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引用次数: 0
Myocardial Structural and Functional Assessment in Fetal Growth Restriction Infants-A Cohort Study: Authors' Reply. 胎儿生长受限婴儿心肌结构和功能评估——一项队列研究：作者回复。
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-17 DOI: 10.1007/s12098-025-05897-w
Vidya Nayak, Ashwal A Jayaram, Leslie Edward Lewis, Jyothi Samanth, Krishnananda Nayak
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引用次数: 0
Radiographic Patterns and Clinical Correlates in Pediatric Community-Acquired Pneumonia. 儿童社区获得性肺炎的影像学表现和临床相关性。
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-17 DOI: 10.1007/s12098-025-05871-6
H S Ramya, Shreeya Joshi, N Pooja
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引用次数: 0
An Outbreak of Vitamin D Toxicity Due to Erroneously Fortified Cooking Oil Consumption: Correspondence. 误用强化食用油导致的维生素D中毒事件：对应。
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-16 DOI: 10.1007/s12098-025-05907-x
Santosh Govind Rathod, Raksha Thakur
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引用次数: 0
Bridging Gaps in Pediatric Obesity Management Through Technology - Are We There? 通过技术弥合儿童肥胖管理的差距-我们在那里吗？
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-15 DOI: 10.1007/s12098-025-05818-x
Dhvani Raithatha, Anurag Bajpai
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引用次数: 0
Epidemiology of Rotavirus Gastroenteritis and Circulating Genotypes Among Hospitalized Children Aged Under 5 Years in Rajkot, Gujarat: Correspondence. 古吉拉特邦拉杰科特5岁以下住院儿童中轮状病毒胃肠炎的流行病学和循环基因型：通信
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-15 DOI: 10.1007/s12098-025-05913-z
Mengting Zhang, Ziyi Ni
{"title":"Epidemiology of Rotavirus Gastroenteritis and Circulating Genotypes Among Hospitalized Children Aged Under 5 Years in Rajkot, Gujarat: Correspondence.","authors":"Mengting Zhang, Ziyi Ni","doi":"10.1007/s12098-025-05913-z","DOIUrl":"https://doi.org/10.1007/s12098-025-05913-z","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alexander Disease Due to a Homozygous GFAP Variant. 纯合子GFAP变异引起的亚历山大病。
IF 2 4区 医学 Q2 PEDIATRICS
Indian Journal of Pediatrics
Pub Date : 2025-12-13 DOI: 10.1007/s12098-025-05889-w
Sahithi Rathod, Roopadarshini Balan, K Sravya, Prajnya Ranganath
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引用次数: 0
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