Pub Date : 2025-01-01Epub Date: 2024-10-30DOI: 10.1007/s12098-024-05311-x
Diao Yu, Yuran Huang, Lan Hu, Nan Luo, Jinlin Liu
{"title":"Sitosterolemia Presenting as Thrombocytopenia and Anemia with Abdominal Pain.","authors":"Diao Yu, Yuran Huang, Lan Hu, Nan Luo, Jinlin Liu","doi":"10.1007/s12098-024-05311-x","DOIUrl":"10.1007/s12098-024-05311-x","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"85"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-11-13DOI: 10.1007/s12098-024-05324-6
Azwin Mengindra Putera, Bahrul Fikri, Muhammad Nasrum Massi, Naoki Shimojo
{"title":"Low Ferritin without Anemia in Indonesian Newborns with Mothers having Second-Hand Smoke Exposure.","authors":"Azwin Mengindra Putera, Bahrul Fikri, Muhammad Nasrum Massi, Naoki Shimojo","doi":"10.1007/s12098-024-05324-6","DOIUrl":"10.1007/s12098-024-05324-6","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"90"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Usefulness of Thymus and Activation-Regulated Chemokine for the Diagnosis of Food Protein-Induced Enterocolitis Syndrome with Sepsis-Like Symptoms in a Pediatric Patient with Trisomy 13.","authors":"Hiroaki Hitomi, Yuji Fujita, Yuhi Takagi, Manabu Miyamoto, Yuji Kano, Shigemi Yoshihara","doi":"10.1007/s12098-024-05329-1","DOIUrl":"10.1007/s12098-024-05329-1","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"106"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: To assess cognitive function and factors affecting it in Indian children with early-onset type 1 diabetes (T1D) (less than 6 y).
Methods: This cross-sectional, single-centre study recruited children diagnosed with T1D before 6 y of age and having a disease duration of at least 2 y, as cases. Controls were age- and sex-matched apparently healthy children or siblings. Children with birth asphyxia, intellectual disability, syndromic children, or pre-existing psychiatric illness were excluded. Enrolled children underwent cognitive assessment using Malin's Intelligence Scale for Indian Children (MISIC), and scores in various subtests were compared between cases and controls.
Results: A total of 60 children were enrolled in each group. When compared to controls, cases had significantly lower scores on most subtests, verbal, performance and overall Intelligence Quotient (IQ- 100.62 ± 3.26 vs. 103.23 ± 1.22). HbA1c >9%, severe hypoglycemia and lesser duration since the last diabetic ketoacidosis (DKA) episode significantly correlated with lower neurocognitive scores.
Conclusions: Children with early onset T1D showed significant deficits in various cognitive domains and IQ. Poor glycemic control, higher glycemic variability and exposure to severe hypoglycemia are risk factors for poor cognitive outcomes in these children. Further longitudinal studies could potentially aid in a finer understanding of factors affecting cognitive functioning in T1D children in developing countries.
目的：评估印度早发性1型糖尿病（T1D）（6岁以下）儿童的认知功能及其影响因素。方法：这项横断面、单中心研究招募了6岁之前被诊断为T1D且疾病持续时间至少为2年的儿童作为病例。对照组是年龄和性别匹配的健康儿童或兄弟姐妹。出生窒息、智力残疾、综合征儿童或已有精神疾病的儿童除外。使用Malin’s Intelligence Scale for Indian children（MISIC）对入选儿童进行认知评估，并比较病例和对照组在各种子测验中的得分。结果：每组共有60名儿童入选。与对照组相比，病例在大多数子测验、言语、表现和整体智商（IQ-100.62）方面的得分明显较低 ± 3.26对103.23 ± 1.22）HbA1c >9%、严重低血糖和自上次糖尿病酮症酸中毒（DKA）发作以来持续时间较短与神经认知评分较低显著相关。结论：早发T1D儿童在各种认知领域和智商方面都存在显著缺陷。血糖控制不佳、血糖变异性较高和暴露于严重低血糖是这些儿童认知结果不佳的危险因素。进一步的纵向研究可能有助于更好地了解发展中国家T1D儿童认知功能的影响因素。
{"title":"Cognitive Function in Early Onset Type 1 Diabetes in Children.","authors":"K Swaminathan, Pamali Mahasweta Nanda, Jaivinder Yadav, Prahbhjot Malhi, Rakesh Kumar, Akhilesh Sharma, Rajni Sharma, Devi Dayal","doi":"10.1007/s12098-023-04901-5","DOIUrl":"10.1007/s12098-023-04901-5","url":null,"abstract":"<p><strong>Objectives: </strong>To assess cognitive function and factors affecting it in Indian children with early-onset type 1 diabetes (T1D) (less than 6 y).</p><p><strong>Methods: </strong>This cross-sectional, single-centre study recruited children diagnosed with T1D before 6 y of age and having a disease duration of at least 2 y, as cases. Controls were age- and sex-matched apparently healthy children or siblings. Children with birth asphyxia, intellectual disability, syndromic children, or pre-existing psychiatric illness were excluded. Enrolled children underwent cognitive assessment using Malin's Intelligence Scale for Indian Children (MISIC), and scores in various subtests were compared between cases and controls.</p><p><strong>Results: </strong>A total of 60 children were enrolled in each group. When compared to controls, cases had significantly lower scores on most subtests, verbal, performance and overall Intelligence Quotient (IQ- 100.62 ± 3.26 vs. 103.23 ± 1.22). HbA1c >9%, severe hypoglycemia and lesser duration since the last diabetic ketoacidosis (DKA) episode significantly correlated with lower neurocognitive scores.</p><p><strong>Conclusions: </strong>Children with early onset T1D showed significant deficits in various cognitive domains and IQ. Poor glycemic control, higher glycemic variability and exposure to severe hypoglycemia are risk factors for poor cognitive outcomes in these children. Further longitudinal studies could potentially aid in a finer understanding of factors affecting cognitive functioning in T1D children in developing countries.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"22-28"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71481064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-10-25DOI: 10.1007/s12098-024-05306-8
Singanamalla Bhanudeep, Bramhini Bhargavi Koneti
{"title":"Successful Management of Acute Necrotizing Encephalopathy in a Child.","authors":"Singanamalla Bhanudeep, Bramhini Bhargavi Koneti","doi":"10.1007/s12098-024-05306-8","DOIUrl":"10.1007/s12098-024-05306-8","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"98"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-11-14DOI: 10.1007/s12098-024-05330-8
Apeksha Singh, Aswin A Anil, Gayathri Mohan, Gopika Chandramohan, Chameli Ratan, K P Lakshmi, R Uday Kumar, Vaishakh Anand
{"title":"A Study on the Emotional and Behavioral Side Effects Associated with Brivaracetam versus Levetiracetam in Pediatric Population with Epilepsy.","authors":"Apeksha Singh, Aswin A Anil, Gayathri Mohan, Gopika Chandramohan, Chameli Ratan, K P Lakshmi, R Uday Kumar, Vaishakh Anand","doi":"10.1007/s12098-024-05330-8","DOIUrl":"10.1007/s12098-024-05330-8","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"94"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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