Innate immune regulation in dental implant osseointegration.

IF 3.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of prosthodontic research Pub Date : 2024-10-16 Epub Date: 2024-02-16 DOI:10.2186/jpr.JPR_D_23_00198
Takeru Kondo, Masahiro Yamada, Hiroshi Egusa
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Abstract

Purpose: Dental implant osseointegration comprises two types of bone formation-contact and distance osteogenesis-which result in bone formation originating from the implant surface or bone edges, respectively. The physicochemical properties of the implant surface regulate initial contact osteogenesis by directly tuning the osteoprogenitor cells in the peri-implant environment. However, whether these implant surface properties can regulate osteoprogenitor cells distant from the implant remains unclear. Innate immune cells, including neutrophils and macrophages, govern bone metabolism, suggesting their involvement in osseointegration and distance osteogenesis. This narrative review discusses the role of innate immunity in osseointegration and the effects of implant surface properties on distant osteogenesis, focusing on innate immune regulation.

Study selection: The role of innate immunity in bone formation and the effects of implant surface properties on innate immune function were reviewed based on clinical, animal, and in vitro studies.

Results: Neutrophils and macrophages are responsible for bone formation during osseointegration, via inflammatory mediators. The microroughness and hydrophilic status of titanium implants have the potential to alleviate this inflammatory response of neutrophils, and induce an anti-inflammatory response in macrophages, to tune both contact and distance osteogenesis through the activation of osteoblasts. Thus, the surface micro-roughness and hydrophilicity of implants can regulate the function of distant osteoprogenitor cells through innate immune cells.

Conclusions: Surface modification of implants aimed at regulating innate immunity may be useful in promoting further osteogenesis and overcoming the limitations encountered in severe situations, such as early loading protocol application.

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牙科种植体骨结合中的先天免疫调节。
目的:牙科种植体骨结合包括两种类型的骨形成--接触成骨和距离成骨,它们分别导致源自种植体表面或骨边缘的骨形成。种植体表面的物理化学特性通过直接调节种植体周围环境中的骨生成细胞来调节最初的接触成骨。然而,这些种植体表面特性是否能调节远离种植体的骨生成细胞仍不清楚。包括中性粒细胞和巨噬细胞在内的先天性免疫细胞控制着骨代谢,这表明它们参与了骨结合和远距离成骨。这篇叙述性综述讨论了先天免疫在骨结合中的作用以及种植体表面特性对远距离成骨的影响,重点关注先天免疫调节:研究选择:根据临床、动物和体外研究对先天性免疫在骨形成中的作用以及种植体表面特性对先天性免疫功能的影响进行了综述:结果:在骨结合过程中,中性粒细胞和巨噬细胞通过炎症介质促进骨形成。钛种植体的微粗糙度和亲水性有可能减轻中性粒细胞的炎症反应,并诱导巨噬细胞产生抗炎反应,通过激活成骨细胞来调节接触成骨和远距离成骨。因此,植入物表面的微粗糙度和亲水性可以通过先天性免疫细胞调节远距离成骨细胞的功能:以调节先天性免疫为目的的植入物表面改良可能有助于促进进一步的成骨,并克服在严重情况下遇到的限制,如早期加载方案的应用。
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来源期刊
Journal of prosthodontic research
Journal of prosthodontic research DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
6.90
自引率
11.10%
发文量
161
期刊介绍: Journal of Prosthodontic Research is published 4 times annually, in January, April, July, and October, under supervision by the Editorial Board of Japan Prosthodontic Society, which selects all materials submitted for publication. Journal of Prosthodontic Research originated as an official journal of Japan Prosthodontic Society. It has recently developed a long-range plan to become the most prestigious Asian journal of dental research regarding all aspects of oral and occlusal rehabilitation, fixed/removable prosthodontics, oral implantology and applied oral biology and physiology. The Journal will cover all diagnostic and clinical management aspects necessary to reestablish subjective and objective harmonious oral aesthetics and function. The most-targeted topics: 1) Clinical Epidemiology and Prosthodontics 2) Fixed/Removable Prosthodontics 3) Oral Implantology 4) Prosthodontics-Related Biosciences (Regenerative Medicine, Bone Biology, Mechanobiology, Microbiology/Immunology) 5) Oral Physiology and Biomechanics (Masticating and Swallowing Function, Parafunction, e.g., bruxism) 6) Orofacial Pain and Temporomandibular Disorders (TMDs) 7) Adhesive Dentistry / Dental Materials / Aesthetic Dentistry 8) Maxillofacial Prosthodontics and Dysphagia Rehabilitation 9) Digital Dentistry Prosthodontic treatment may become necessary as a result of developmental or acquired disturbances in the orofacial region, of orofacial trauma, or of a variety of dental and oral diseases and orofacial pain conditions. Reviews, Original articles, technical procedure and case reports can be submitted. Letters to the Editor commenting on papers or any aspect of Journal of Prosthodontic Research are welcomed.
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