{"title":"Tannin-albumin particles as stable carriers of medicines.","authors":"Nelli Ohanyan, Narek Abelyan, Arpi Manukyan, Vardan Hayrapetyan, Samvel Chailyan, Susanna Tiratsuyan, Kristine Danielyan","doi":"10.2217/nnm-2023-0275","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> The effectiveness of a drug is dependent on its accumulation at the site of therapeutic action, as well as its time in circulation. The aim of the research was the creation of stable albumin/tannin (punicalagin, punicalin) particles, which might serve for the delivery of medicines. <b>Methods:</b> Numerous chromatographic and analytical methods, docking analyses and <i>in vivo</i> testing were applied and used. <b>Results:</b> Stable tannin-albumin/medicine particles with a diameter of ∼100 nm were obtained. The results of <i>in vivo</i> experiments proved that tannin-albumin particles are more stable than albumin particles. <b>Conclusion:</b> Based on the experiments and docking analyses, these stable particles can carry an extended number of medicines, with diverse chemical structures.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"689-708"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine (London, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/nnm-2023-0275","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/13 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The effectiveness of a drug is dependent on its accumulation at the site of therapeutic action, as well as its time in circulation. The aim of the research was the creation of stable albumin/tannin (punicalagin, punicalin) particles, which might serve for the delivery of medicines. Methods: Numerous chromatographic and analytical methods, docking analyses and in vivo testing were applied and used. Results: Stable tannin-albumin/medicine particles with a diameter of ∼100 nm were obtained. The results of in vivo experiments proved that tannin-albumin particles are more stable than albumin particles. Conclusion: Based on the experiments and docking analyses, these stable particles can carry an extended number of medicines, with diverse chemical structures.
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