Real-world treatment of metastatic hormone-sensitive prostate cancer in the USA, Europe and Asia.

IF 3 4区 医学 Q2 ONCOLOGY Future oncology Pub Date : 2024-05-01 Epub Date: 2024-02-14 DOI:10.2217/fon-2023-0814
Peter J Goebell, Rutika Raina, Stephanie Chen, Sanika Rege, Ruchit Shah, Jamie Partridge Grossman, A Reginald Waldeck
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Abstract

Aim: To characterize real-world patients with metastatic hormone-sensitive prostate cancer (mHSPC) and treating physicians and evaluate treatment trends and baseline concordance versus guidelines internationally. Materials & methods: Retrospective, cross-sectional data from the Ipsos Global Oncology Monitor database 2018-2020 were used for descriptive analysis of mHSPC patients, treating physicians and treatment utilization. Results: Among the 6198 mHSPC patients from five countries, the most common treatment was either androgen deprivation therapy (ADT) monotherapy or first-generation androgen receptor inhibitor + ADT. Second-generation androgen receptor inhibitor use was only initiating but increasing over the study period. Conclusion: Despite contemporaneous guidelines recommending treatment intensification of ADT in combination with novel antihormonals or docetaxel, 76.1% of reported mHSPC patients received non-guideline-concordant care.

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美国、欧洲和亚洲对转移性激素敏感前列腺癌的实际治疗情况。
目的:描述现实世界中转移性激素敏感性前列腺癌(mHSPC)患者和主治医生的特征,评估治疗趋势以及与国际指南的基线一致性。材料与方法:采用益普索全球肿瘤监测数据库 2018-2020 年的回顾性横截面数据,对 mHSPC 患者、主治医生和治疗利用率进行描述性分析。结果:在来自五个国家的6198名mHSPC患者中,最常见的治疗方法是雄激素剥夺疗法(ADT)单药治疗或第一代雄激素受体抑制剂+ADT。第二代雄激素受体抑制剂的使用才刚刚开始,但在研究期间不断增加。结论尽管当时的指南建议加强ADT与新型抗激素类药物或多西他赛联合治疗,但在报告的mHSPC患者中,76.1%的患者接受的治疗与指南不一致。
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来源期刊
Future oncology
Future oncology ONCOLOGY-
CiteScore
5.40
自引率
3.00%
发文量
335
审稿时长
4-8 weeks
期刊介绍: Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.
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