Joel Rivera-Concepcion , Ying-Chun Lo , Dipesh Uprety , Alex A. Adjei , Vinicius Ernani , Konstantinos Leventakos
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引用次数: 0
Abstract
This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.
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