Pub Date : 2026-01-07DOI: 10.1016/j.cpccr.2026.100405
Atif Saleem Siddiqui
A primary yolk sac tumor of the lung is an extremely rare type of extragonadal germ cell tumor that originates in the lung parenchyma. We report a case of a large pulmonary yolk sac tumor in the right lower lobe with brain metastasis, treated with chemotherapy. Common symptoms of pulmonary yolk sac tumors include cough, chest pain, and shortness of breath. Risk factors for developing primary yolk sac tumors of the lung are not well defined. Elevated alpha-fetoprotein (AFP) levels are a characteristic finding in these tumors and can aid in both diagnosis and monitoring treatment response. Primary yolk sac tumor is an aggressive malignancy. Comprehensive treatment typically involves a combination of neoadjuvant chemotherapy, complete surgical resection, and postoperative chemotherapy, along with careful monitoring of AFP levels and management of complications to optimize outcomes.
{"title":"Primary pulmonary yolk sac tumor: A case report","authors":"Atif Saleem Siddiqui","doi":"10.1016/j.cpccr.2026.100405","DOIUrl":"10.1016/j.cpccr.2026.100405","url":null,"abstract":"<div><div>A primary yolk sac tumor of the lung is an extremely rare type of extragonadal germ cell tumor that originates in the lung parenchyma. We report a case of a large pulmonary yolk sac tumor in the right lower lobe with brain metastasis, treated with chemotherapy. Common symptoms of pulmonary yolk sac tumors include cough, chest pain, and shortness of breath. Risk factors for developing primary yolk sac tumors of the lung are not well defined. Elevated alpha-fetoprotein (AFP) levels are a characteristic finding in these tumors and can aid in both diagnosis and monitoring treatment response. Primary yolk sac tumor is an aggressive malignancy. Comprehensive treatment typically involves a combination of neoadjuvant chemotherapy, complete surgical resection, and postoperative chemotherapy, along with careful monitoring of AFP levels and management of complications to optimize outcomes.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"21 ","pages":"Article 100405"},"PeriodicalIF":0.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Basal cell carcinoma (BCC) is the most common skin cancer. In this study, a novel topical approach using formulated methylene blue gel and repairing gel was applied to treat two painful recurrent ulcerative BCCs and one nodular BCC in one diabetic/dialysis 78-year-old patient, who was contraindicated for further surgery due to the patient’s performance status and comorbidities. External radiation therapy was not feasible because the tumors were located at multiple sites, which made it difficult to treat all lesions. Both the recurrent ulcerative BCCs and the nodular BCC healed completely after 75 and 24 days, respectively. No recurrence was observed after one year of follow-up. This approach is a non-invasive and safe method, and further research is needed to substantiate its efficacy.
{"title":"Treatment of inoperable painful recurrent basal cell carcinoma by a novel approach","authors":"Abolfazl Zanghaei , Ehsan Soltani , Mahdi Razmara , Seyedmajid Mousavijavardi , Daryoush Hamidi Alamdari","doi":"10.1016/j.cpccr.2026.100403","DOIUrl":"10.1016/j.cpccr.2026.100403","url":null,"abstract":"<div><div>Basal cell carcinoma (BCC) is the most common skin cancer. In this study, a novel topical approach using formulated methylene blue gel and repairing gel was applied to treat two painful recurrent ulcerative BCCs and one nodular BCC in one diabetic/dialysis 78-year-old patient, who was contraindicated for further surgery due to the patient’s performance status and comorbidities. External radiation therapy was not feasible because the tumors were located at multiple sites, which made it difficult to treat all lesions. Both the recurrent ulcerative BCCs and the nodular BCC healed completely after 75 and 24 days, respectively. No recurrence was observed after one year of follow-up. This approach is a non-invasive and safe method, and further research is needed to substantiate its efficacy.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"21 ","pages":"Article 100403"},"PeriodicalIF":0.2,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.cpccr.2026.100404
Saishravan Shyamsundar , Mateo Sarmiento Bustamante , Larissa Borys , Megan S. Lim , Adam Bagg , Mary Jo Lechowicz , Daisy Alapat , Amy Chadburn , Gordan Srkalovic , Frits van Rhee , Bridget Austin , Joshua D. Brandstadter , David C. Fajgenbaum
ALK-negative anaplastic large cell lymphoma is a well-established hematologic complication of prosthetic breast implantation, but other rare conditions should also be considered. We report a case of a 36-year-old female with bilateral retropectoral breast implants since age 20 who presented with fatigue, lower extremity edema, fevers, and a slowly growing left breast mass. Ultrasound of the left breast revealed a 6 × 6 cm left upper quadrant mass. Surgical excision identified pathologic features consistent with hyaline-vascular unicentric Castleman disease (UCD). This is the first case of breast-implant associated UCD, expanding the differential diagnosis for masses associated with prosthetic breast implantation.
{"title":"Breast-implant associated unicentric castleman disease: a case report","authors":"Saishravan Shyamsundar , Mateo Sarmiento Bustamante , Larissa Borys , Megan S. Lim , Adam Bagg , Mary Jo Lechowicz , Daisy Alapat , Amy Chadburn , Gordan Srkalovic , Frits van Rhee , Bridget Austin , Joshua D. Brandstadter , David C. Fajgenbaum","doi":"10.1016/j.cpccr.2026.100404","DOIUrl":"10.1016/j.cpccr.2026.100404","url":null,"abstract":"<div><div>ALK-negative anaplastic large cell lymphoma is a well-established hematologic complication of prosthetic breast implantation, but other rare conditions should also be considered. We report a case of a 36-year-old female with bilateral retropectoral breast implants since age 20 who presented with fatigue, lower extremity edema, fevers, and a slowly growing left breast mass. Ultrasound of the left breast revealed a 6 × 6 cm left upper quadrant mass. Surgical excision identified pathologic features consistent with hyaline-vascular unicentric Castleman disease (UCD). This is the first case of breast-implant associated UCD, expanding the differential diagnosis for masses associated with prosthetic breast implantation.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"21 ","pages":"Article 100404"},"PeriodicalIF":0.2,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The advent of targeted therapies, such as panitumumab, has significantly improved treatment outcomes for metastatic colorectal cancer (mCRC). However, these therapies can also induce unique side effects, including trichomegaly, characterized by the abnormal thickening, lengthening, and curling of eyelashes.
Case Report Management & Outcome
We report the case of a 67-year-old male with metastatic colorectal cancer who developed trichomegaly following treatment with panitumumab. The patient was initially treated with FOLFOX (fluorouracil, leucovorin, and oxaliplatin) and bevacizumab, but received panitumumab after disease progression. Two months after starting panitumumab therapy, the patient exhibited significant elongation and curling of the eyelashes. Despite the discontinuation of panitumumab due to disease progression, the trichomegaly persisted.
Discussion
Panitumumab-induced trichomegaly, while not requiring discontinuation of treatment, can be persistent and may cause discomfort. Awareness and management of this side effect are essential, especially considering its potential impact on patients' quality of life. Future studies are needed to better understand the mechanisms and long-term implications of panitumumab-associated trichomegaly.
{"title":"Panitumumab-induced trichomegaly in a patient with metastatic colorectal cancer: Case report and systematic literature review","authors":"Enes Erul , Erman Akkus , Fatih Koksal , Abdulhakim Konukman , Arzu Yasar","doi":"10.1016/j.cpccr.2025.100402","DOIUrl":"10.1016/j.cpccr.2025.100402","url":null,"abstract":"<div><h3>Introduction</h3><div>The advent of targeted therapies, such as panitumumab, has significantly improved treatment outcomes for metastatic colorectal cancer (mCRC). However, these therapies can also induce unique side effects, including trichomegaly, characterized by the abnormal thickening, lengthening, and curling of eyelashes.</div></div><div><h3>Case Report Management & Outcome</h3><div>We report the case of a 67-year-old male with metastatic colorectal cancer who developed trichomegaly following treatment with panitumumab. The patient was initially treated with FOLFOX (fluorouracil, leucovorin, and oxaliplatin) and bevacizumab, but received panitumumab after disease progression. Two months after starting panitumumab therapy, the patient exhibited significant elongation and curling of the eyelashes. Despite the discontinuation of panitumumab due to disease progression, the trichomegaly persisted.</div></div><div><h3>Discussion</h3><div>Panitumumab-induced trichomegaly, while not requiring discontinuation of treatment, can be persistent and may cause discomfort. Awareness and management of this side effect are essential, especially considering its potential impact on patients' quality of life. Future studies are needed to better understand the mechanisms and long-term implications of panitumumab-associated trichomegaly.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"21 ","pages":"Article 100402"},"PeriodicalIF":0.2,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-21DOI: 10.1016/j.cpccr.2025.100401
Abdulmajeed Albarrak
Introduction: Upper gastrointestinal bleeding (UGIB) is a potentially life-threatening condition that most commonly arises from peptic ulcers, esophageal varices due to portal hypertension, or mucosal erosions. Variceal bleeding in the absence of liver disease is uncommon and warrants thorough investigation.
Case Presentation: This case report presents a 56-year-old male who experienced his first episode of hematemesis and melena. Endoscopic evaluation revealed a high-risk bleeding fundal varix, despite no clinical or laboratory evidence of chronic liver disease. Abdominal ultrasound revealed a large left renal mass consistent with renal cell carcinoma, with extensive vascular thromboses involving the portal vein, inferior vena cava, and splenic vein, leading to localized portal hypertension and variceal formation. Despite planned diagnostic and therapeutic interventions, the patient suffered a fatal pulmonary embolism. This case underscores the importance of considering malignancy-related vascular complications in non-cirrhotic variceal bleeding.
Conclusion: The presentation of UGIB due to isolated gastric varices in a non-cirrhotic patient should prompt evaluation for underlying malignancies, including renal cell carcinoma (RCC). The aggressive vascular invasion characteristic of RCC can lead to significant complications, including portal hypertension and thromboembolic events. Early diagnosis and management are essential to improve patient outcomes.
{"title":"Unexpected source of massive GI bleed: metastatic renal cell carcinoma and widespread thrombosis – a case report","authors":"Abdulmajeed Albarrak","doi":"10.1016/j.cpccr.2025.100401","DOIUrl":"10.1016/j.cpccr.2025.100401","url":null,"abstract":"<div><div>Introduction: Upper gastrointestinal bleeding (UGIB) is a potentially life-threatening condition that most commonly arises from peptic ulcers, esophageal varices due to portal hypertension, or mucosal erosions. Variceal bleeding in the absence of liver disease is uncommon and warrants thorough investigation.</div><div>Case Presentation: This case report presents a 56-year-old male who experienced his first episode of hematemesis and melena. Endoscopic evaluation revealed a high-risk bleeding fundal varix, despite no clinical or laboratory evidence of chronic liver disease. Abdominal ultrasound revealed a large left renal mass consistent with renal cell carcinoma, with extensive vascular thromboses involving the portal vein, inferior vena cava, and splenic vein, leading to localized portal hypertension and variceal formation. Despite planned diagnostic and therapeutic interventions, the patient suffered a fatal pulmonary embolism. This case underscores the importance of considering malignancy-related vascular complications in non-cirrhotic variceal bleeding.</div><div>Conclusion: The presentation of UGIB due to isolated gastric varices in a non-cirrhotic patient should prompt evaluation for underlying malignancies, including renal cell carcinoma (RCC). The aggressive vascular invasion characteristic of RCC can lead to significant complications, including portal hypertension and thromboembolic events. Early diagnosis and management are essential to improve patient outcomes.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"21 ","pages":"Article 100401"},"PeriodicalIF":0.2,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.cpccr.2025.100399
Ridwana Maher Manna , Sumyta Rahman , Nomaan Hassan Khan , Sabrina Nahin , Raihana Ferdousi , Mohammad Delwer Hossain Hawlader , Mohammad Ashraful Amin
Postmenopausal bleeding is a common presentation of gynecological malignancies, often associated with endometrial carcinoma. However, uterine carcinosarcoma is a rare and aggressive malignancy that can present similarly. This case report describes a 55-year-old woman with postmenopausal bleeding and hematometra, raising a high clinical suspicion of endometrial carcinoma, who was ultimately diagnosed with uterine carcinosarcoma on histopathologic examination. This case highlights the diagnostic challenges and the importance of histopathological evaluation in atypical presentations.
{"title":"Postmenopausal bleeding and hematometra revealing uterine carcinosarcoma","authors":"Ridwana Maher Manna , Sumyta Rahman , Nomaan Hassan Khan , Sabrina Nahin , Raihana Ferdousi , Mohammad Delwer Hossain Hawlader , Mohammad Ashraful Amin","doi":"10.1016/j.cpccr.2025.100399","DOIUrl":"10.1016/j.cpccr.2025.100399","url":null,"abstract":"<div><div>Postmenopausal bleeding is a common presentation of gynecological malignancies, often associated with endometrial carcinoma. However, uterine carcinosarcoma is a rare and aggressive malignancy that can present similarly. This case report describes a 55-year-old woman with postmenopausal bleeding and hematometra, raising a high clinical suspicion of endometrial carcinoma, who was ultimately diagnosed with uterine carcinosarcoma on histopathologic examination. This case highlights the diagnostic challenges and the importance of histopathological evaluation in atypical presentations.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"20 ","pages":"Article 100399"},"PeriodicalIF":0.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Well-differentiated papillary mesothelial tumor (WDPMT) is a rare mesothelial neoplasm that typically arises in the peritoneum of women of reproductive age and generally follows an indolent course, although occasional recurrence or malignant transformation has been reported. WDPMT of the fallopian tube is extremely uncommon. We report the case of a 46-year-old woman with long-standing menorrhagia who underwent total abdominal hysterectomy with bilateral salpingectomy for uterine leiomyomas, during which a solitary 5-mm nodule was incidentally identified on the left fallopian tube. Histological examination showed fibrovascular cores lined by cuboidal mesothelial cells with minimal atypia and no stromal invasion, while immunohistochemistry revealed WT1 and calretinin positivity, estrogen receptor and progesterone receptor negativity, weak focal PAX8 staining, and retained nuclear expression of BRCA1-associated protein 1 (BAP1) and methylthioadenosine phosphorylase (MTAP). These findings supported a diagnosis of WDPMT. This case adds to the limited literature on fallopian tube WDPMT and highlights the importance of recognizing this rare entity and considering long-term follow-up, given its generally indolent but occasionally unpredictable behavior.
{"title":"Well-differentiated papillary mesothelial tumor of the fallopian tube: A case report","authors":"Hideko Kotani , Sohei Kitazawa , Hisae Kaneko , Mie Tasaka","doi":"10.1016/j.cpccr.2025.100398","DOIUrl":"10.1016/j.cpccr.2025.100398","url":null,"abstract":"<div><div>Well-differentiated papillary mesothelial tumor (WDPMT) is a rare mesothelial neoplasm that typically arises in the peritoneum of women of reproductive age and generally follows an indolent course, although occasional recurrence or malignant transformation has been reported. WDPMT of the fallopian tube is extremely uncommon. We report the case of a 46-year-old woman with long-standing menorrhagia who underwent total abdominal hysterectomy with bilateral salpingectomy for uterine leiomyomas, during which a solitary 5-mm nodule was incidentally identified on the left fallopian tube. Histological examination showed fibrovascular cores lined by cuboidal mesothelial cells with minimal atypia and no stromal invasion, while immunohistochemistry revealed WT1 and calretinin positivity, estrogen receptor and progesterone receptor negativity, weak focal PAX8 staining, and retained nuclear expression of BRCA1-associated protein 1 (BAP1) and methylthioadenosine phosphorylase (MTAP). These findings supported a diagnosis of WDPMT. This case adds to the limited literature on fallopian tube WDPMT and highlights the importance of recognizing this rare entity and considering long-term follow-up, given its generally indolent but occasionally unpredictable behavior.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"20 ","pages":"Article 100398"},"PeriodicalIF":0.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malignant melanoma accounts for 1–4 % of all gynecological malignancies, with most cases originating in the vulva and/or vagina. Primary malignant uterine melanomas are rare. Although there are reports of initial treatment with nivolumab and combination therapy with nivolumab and radiotherapy for recurrent lesions, no standardized treatment protocol has been established. This case report describes a 74-year-old woman diagnosed with International Federation of Gynecology and Obstetrics stage IV primary malignant melanoma of the cervix. Nivolumab and radiotherapy were concurrently administered to the primary lesion, resulting in tumor mass reduction. However, new pelvic lymph node metastases were observed at 6 months. The same combination therapy was administered but proved ineffective, leading to disease progression and death. To our best knowledge, this is the first report on the combined use of immune checkpoint inhibitors and radiotherapy as the initial treatment for primary malignant melanoma of the cervix. In advanced cases, initial treatment may result in primary lesion reduction and symptom control.
{"title":"Primary advanced malignant melanoma of the uterine cervix treated with a combination of nivolumab and concurrent radiotherapy: A case report","authors":"Norihito Kamo , Shigenori Furukawa , Asami Kato , Chikako Okabe , Hideki Miura , Tetsu Sato , Shu Soeda , Keiya Fujimori","doi":"10.1016/j.cpccr.2025.100396","DOIUrl":"10.1016/j.cpccr.2025.100396","url":null,"abstract":"<div><div>Malignant melanoma accounts for 1–4 % of all gynecological malignancies, with most cases originating in the vulva and/or vagina. Primary malignant uterine melanomas are rare. Although there are reports of initial treatment with nivolumab and combination therapy with nivolumab and radiotherapy for recurrent lesions, no standardized treatment protocol has been established. This case report describes a 74-year-old woman diagnosed with International Federation of Gynecology and Obstetrics stage IV primary malignant melanoma of the cervix. Nivolumab and radiotherapy were concurrently administered to the primary lesion, resulting in tumor mass reduction. However, new pelvic lymph node metastases were observed at 6 months. The same combination therapy was administered but proved ineffective, leading to disease progression and death. To our best knowledge, this is the first report on the combined use of immune checkpoint inhibitors and radiotherapy as the initial treatment for primary malignant melanoma of the cervix. In advanced cases, initial treatment may result in primary lesion reduction and symptom control.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"20 ","pages":"Article 100396"},"PeriodicalIF":0.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.cpccr.2025.100397
Palak Vora, Akash Katkar, Parthasaradhi Reddy
Introduction and importance
Gastro intestinal stromal tumours (GIST) are benign to malignant mesenchymal tumours comprising ∼1 % of GI malignancies. They are soft tissue sarcomas most commonly arising from GI system.[1–3] Most common site being stomach and rarely arise from other parts of intestines.
Case presentation
We present a case of a 49 year old male patient diagnosed with jejunal GIST presented with urinary complaints, and found to have painless abdominal lump which was mobile. Radiological investigations were showing right iliac fossa mass. On surgical exploration, we found a mass arising from antimesenteric border of jejunum and was adherent to greater omentum above and lateral peritoneal wall inferiorly. Complete resection of the tumour with Jejuno-jejunal anastomosis was performed. Histopathology of the excised tumour also confirmed the diagnosis of GIST.
Clinical discussion
GIST commonly found in stomach and rarely in various parts of GI system. Treatment depends on tumour size, type and location. Complete resection followed by chemotherapy if required, is the mainstay of treatment.
Conclusion
A GIST can also be considered as a differential diagnosis for abdominal s symptoms which has various presentation and outcome based upon the type and attachment to nearby structures. Surgical resection remains the initial part of management.
{"title":"A rare case report of unusual presentation of jejunal gastro intestinal stromal tumor","authors":"Palak Vora, Akash Katkar, Parthasaradhi Reddy","doi":"10.1016/j.cpccr.2025.100397","DOIUrl":"10.1016/j.cpccr.2025.100397","url":null,"abstract":"<div><h3>Introduction and importance</h3><div>Gastro intestinal stromal tumours (GIST) are benign to malignant mesenchymal tumours comprising ∼1 % of GI malignancies. They are soft tissue sarcomas most commonly arising from GI system.<sup>[1–3]</sup> Most common site being stomach and rarely arise from other parts of intestines.</div></div><div><h3>Case presentation</h3><div>We present a case of a 49 year old male patient diagnosed with jejunal GIST presented with urinary complaints, and found to have painless abdominal lump which was mobile. Radiological investigations were showing right iliac fossa mass. On surgical exploration, we found a mass arising from antimesenteric border of jejunum and was adherent to greater omentum above and lateral peritoneal wall inferiorly. Complete resection of the tumour with Jejuno-jejunal anastomosis was performed. Histopathology of the excised tumour also confirmed the diagnosis of GIST.</div></div><div><h3>Clinical discussion</h3><div>GIST commonly found in stomach and rarely in various parts of GI system. Treatment depends on tumour size, type and location. Complete resection followed by chemotherapy if required, is the mainstay of treatment.</div></div><div><h3>Conclusion</h3><div>A GIST can also be considered as a differential diagnosis for abdominal s symptoms which has various presentation and outcome based upon the type and attachment to nearby structures. Surgical resection remains the initial part of management.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"20 ","pages":"Article 100397"},"PeriodicalIF":0.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05DOI: 10.1016/j.cpccr.2025.100395
Tanya Odisho , Alexander Laskaris , Sohayb Faleh , Louis-Martin Boucher , Ali Bessissow , Sinziana Dumitra
Introduction
Desmoid tumors are rare fibroblastic growths originating in mesenchymal tissues. While lacking metastatic potential, these tumors display heterogenous clinical behaviour. They can frequently recur and encroach upon surrounding structures, causing significant morbidity. Traditional management has shifted from surgical resection to more conservative strategies. Cryoablation has emerged as a promising therapeutic option, especially for tumors in anatomically complex or surgically challenging locations. However, in cases involving tumors abutting visceral organs, the risk of cryoablation-induced injury such as bowel perforation and enterocutaneous fistula formation limits its application.
Patient and methods
We present a novel case of a 38-year-old female with a biopsy-proven abdominal wall desmoid tumor exhibiting progressive growth, worsening pain and radiologic proximity to the colon following two prior gynecologic surgeries, who underwent successful percutaneous cryoablation guided by pneumoperitoneum-assisted laparoscopic visualization.
Results
This approach facilitated real-time visualization of intra-abdominal structures and dynamic assessment of tumor-bowel separation. This obviated the need for bowel mobilization and permitted direct and safe ultrasound-guided percutaneous cryoablation. Postoperative recovery was uneventful with no complications observed and the patient became pain free two days after surgery.
Conclusion
This case exemplifies how a multidisciplinary strategy, combining laparoscopy and interventional radiology expertise of cryoablation, can be used in the management of complex desmoid tumors to enhance safety and broaden treatment eligibility for patients with tumors in high-risk locations.
{"title":"Laparoscopic assisted percutaneous cryoablation of abdominal wall desmoid tumor: a case report of a novel technical approach","authors":"Tanya Odisho , Alexander Laskaris , Sohayb Faleh , Louis-Martin Boucher , Ali Bessissow , Sinziana Dumitra","doi":"10.1016/j.cpccr.2025.100395","DOIUrl":"10.1016/j.cpccr.2025.100395","url":null,"abstract":"<div><h3>Introduction</h3><div>Desmoid tumors are rare fibroblastic growths originating in mesenchymal tissues. While lacking metastatic potential, these tumors display heterogenous clinical behaviour. They can frequently recur and encroach upon surrounding structures, causing significant morbidity. Traditional management has shifted from surgical resection to more conservative strategies. Cryoablation has emerged as a promising therapeutic option, especially for tumors in anatomically complex or surgically challenging locations. However, in cases involving tumors abutting visceral organs, the risk of cryoablation-induced injury such as bowel perforation and enterocutaneous fistula formation limits its application.</div></div><div><h3>Patient and methods</h3><div>We present a novel case of a 38-year-old female with a biopsy-proven abdominal wall desmoid tumor exhibiting progressive growth, worsening pain and radiologic proximity to the colon following two prior gynecologic surgeries, who underwent successful percutaneous cryoablation guided by pneumoperitoneum-assisted laparoscopic visualization.</div></div><div><h3>Results</h3><div>This approach facilitated real-time visualization of intra-abdominal structures and dynamic assessment of tumor-bowel separation. This obviated the need for bowel mobilization and permitted direct and safe ultrasound-guided percutaneous cryoablation. Postoperative recovery was uneventful with no complications observed and the patient became pain free two days after surgery.</div></div><div><h3>Conclusion</h3><div>This case exemplifies how a multidisciplinary strategy, combining laparoscopy and interventional radiology expertise of cryoablation, can be used in the management of complex desmoid tumors to enhance safety and broaden treatment eligibility for patients with tumors in high-risk locations.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"20 ","pages":"Article 100395"},"PeriodicalIF":0.2,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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