JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties.

IF 3.3 3区 生物学 Q3 CELL BIOLOGY Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI:10.1080/19336918.2024.2316576
Yibeini Wu, Yiling Zhao, Ziman Guan, Sajjad Esmaeili, Zhicheng Xiao, Diji Kuriakose
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Abstract

The intensive study and investigation of neuroprotective therapy for central nervous system (CNS) diseases is ongoing. Due to shared mechanisms of neurodegeneration, a neuroprotective approach might offer benefits across multiple neurological disorders, despite variations in symptoms or injuries. C-Jun N-terminal Kinase 3 (JNK3) is found primarily in the CNS and is involved in physiological processes such as brain development, synapse formation, and memory formation. The potential of JNK3 as a target for pharmacological development holds promise for advancing neuroprotective therapies. Developing small molecule JNK3 inhibitors into drugs with neuroprotective qualities could facilitate neuronal restoration and self-repair. This review focuses on elucidating key neuroprotective mechanisms, exploring the interplay between neurodegenerative diseases and neuroprotection, and discussing advancements in JNK3 inhibitor drug development.

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JNK3 抑制剂是一种具有神经保护特性的有前途的药物。
针对中枢神经系统(CNS)疾病的神经保护疗法的深入研究和调查正在进行中。由于神经变性的机制相同,尽管症状或损伤各不相同,但神经保护方法可能会给多种神经系统疾病带来益处。C-Jun N-terminal Kinase 3(JNK3)主要存在于中枢神经系统,参与大脑发育、突触形成和记忆形成等生理过程。JNK3 作为药理开发靶点的潜力为推进神经保护疗法带来了希望。将小分子 JNK3 抑制剂开发成具有神经保护特性的药物可促进神经元的恢复和自我修复。本综述将重点阐明关键的神经保护机制,探讨神经退行性疾病与神经保护之间的相互作用,并讨论 JNK3 抑制剂药物开发的进展。
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来源期刊
CiteScore
6.40
自引率
0.00%
发文量
7
审稿时长
53 weeks
期刊介绍: Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
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