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Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.
IF 3.3 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2025-12-01 Epub Date: 2024-12-18 DOI: 10.1080/19336918.2024.2442349
Zeyu Wang, Taiyuan Liu, Kang He, Longyun Wang, Xiaoxuan Ma, Zhaoyun Yang, Yingchao Zhang, Lijing Zhao

Background: Research on the function of HGH1 in breast cancer remains lacking.

Methods: TCGAand GEO (GSE45827) datasets investigated discrepancies in HGH1 expression in BC. An aggregate of 106 clinical samples were gathered through immunohistochemistry, KM curves were drawn for prognostic analysis, and the function of HGH1 of BC was predicted. Finally, the effects of HGH1 knockdown on MDA-MB-231 and MCF-7 BC cells were verified via CCK8, invasion, wound healing and colony formation assays.

Results: HGH1 is highly expressed in BC and is linked to unfavorable prognosis. HGH1 overexpression is connected to keratinization and the cell cycle and is closely related to ER and PR expression and tumor stage in BC patients. Knocking down HGH1 in BC cells inhibited the viability, invasion and migration.

Conclusion: Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.

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引用次数: 0
Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer.
IF 3.3 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2025-12-01 Epub Date: 2024-12-07 DOI: 10.1080/19336918.2024.2434209
Zhe Liu, Xiaofeng Pu

The research endeavors to expound the role of ORM1 in bladder cancer (BCa) and the implied response mechanism. RT-qPCR and Western blotting examined ORM1 and S100A12 expression. Functional experiments assessed the cellular phenotypes. HDOCK and Co-IP confirmed the interaction of ORM1 and S100A12. Western blotting tested apoptosis- and ERK signaling-associated proteins. ORM1 and S100A12 were abundant in the BCa cells. ORM1 or S100A12 loss impaired cell proliferation, migration, and invasion, and aggravated cell apoptosis. ORM1 interacted with S100A12. ORM1 knockdown down-regulated S100A12 expression and inactivated ERK signaling.S100A12 overexpression or ERK activator reversed the impacts of ORM1 interference on ERK signaling and BCa cells. ORM1 mightdrive BCa via binding to S100A12 and activating ERK signaling.

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引用次数: 0
Fe3O4 nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis. 含有甘草酸的Fe3O4纳米粒子通过RORB/EMILIN1轴抑制结直肠癌转移
IF 3.3 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI: 10.1080/19336918.2024.2427585
Xiaodong Fan, Chunyang Lv, Meiling Xue, Peng Meng, Xiaoping Qian

This research aims to study the effect of magnetic nanoparticles of Fe3O4 (MNP Fe3O4) containing gambogic acid (GA-MNP Fe3O4) on colorectal cancer (CRC). MNP Fe3O4 enhanced the antitumor effect of GA by inhibiting the malignant behavior of CRC cells. RORB was a target of GA, and GA activated RORB expression to inhibit metastasis of CRC. Knockdown of RORB impaired the effect of GA-MNP Fe3O4 on CRC metastasis. EMILIN1 was a target of RORB, and RORB promoted transcription of EMILIN1. Overexpression of EMILIN1 reversed the effect of knockdown of RORB on GA-MNP Fe3O4 and inhibited metastasis in CRC. These findings revealed that MNP Fe3O4 enhanced the antitumor effect of GA and activated RORB to promote EMILIN1 transcription and inhibit CRC metastasis.

本研究旨在探讨含有甘草酸的磁性纳米颗粒Fe3O4(MNP Fe3O4)(GA-MNP Fe3O4)对结直肠癌(CRC)的影响。MNP Fe3O4通过抑制CRC细胞的恶性行为增强了GA的抗肿瘤作用。RORB是GA的靶点,GA激活RORB的表达以抑制CRC的转移。敲除RORB会削弱GA-MNP Fe3O4对CRC转移的影响。EMILIN1是RORB的靶标,RORB促进EMILIN1的转录。EMILIN1的过表达逆转了RORB敲除对GA-MNP Fe3O4的影响,并抑制了CRC的转移。这些研究结果表明,MNP Fe3O4增强了GA的抗肿瘤作用,并激活了RORB,促进了EMILIN1的转录,抑制了CRC的转移。
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引用次数: 0
Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma. 敲除 PIK3R6 会阻碍透明细胞肾细胞癌的发生和发展。
IF 3.2 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2024-12-01 Epub Date: 2024-06-03 DOI: 10.1080/19336918.2024.2353920
Jia Yang, Xiaoni Zhong, Xiaoling Gao, Wenyi Xie, Yaokai Chen, Yuanjiang Liao, Peilin Zhang

In this research, we investigated the role of PIK3R6, a regulatory subunit of PI3Kγ, known for its tumor-promoting properties, in clear cell renal cell carcinoma (CCRCC). Utilizing the UALCAN website, we found PIK3R6 upregulated in CCRCC, correlating with lower survival rates. We compared PIK3R6 expression in CCRCC tumor tissues and adjacent normal tissues using immunohistochemistry. Post RNA interference-induced knockdown of PIK3R6 in 786-O and ACHN cell lines, we performed CCK-8, colony formation, Edu staining, flow cytometry, wound healing, and transwell assays. Results showed that PIK3R6 silencing reduced cell proliferation, migration, and invasion, and induced G0/G1 phase arrest and apoptosis. Molecular analysis revealed decreased CDK4, Cyclin D1, N-cadherin, Vimentin, Bcl-2, p-PI3K and p-AKT, with increased cleaved caspase-3, Bax, and E-cadherin levels in CCRCC cells. Moreover, inhibiting PIK3R6 hindered tumor growth. These findings suggest a significant role for PIK3R6 in CCRCC cell proliferation and metastasis, presenting it as a potential therapeutic target.

在这项研究中,我们调查了PIK3R6在透明细胞肾细胞癌(CCRCC)中的作用,PIK3R6是PI3Kγ的一个调节亚基,以其肿瘤促进特性而闻名。利用 UALCAN 网站,我们发现 PIK3R6 在 CCRCC 中上调,与较低的生存率相关。我们使用免疫组化方法比较了 PIK3R6 在 CCRCC 肿瘤组织和邻近正常组织中的表达。在 RNA 干扰诱导敲除 786-O 和 ACHN 细胞系中的 PIK3R6 后,我们进行了 CCK-8、集落形成、Edu 染色、流式细胞术、伤口愈合和透孔试验。结果表明,PIK3R6沉默可减少细胞增殖、迁移和侵袭,并诱导细胞G0/G1期停滞和凋亡。分子分析表明,CCRCC细胞中CDK4、细胞周期蛋白D1、N-钙粘蛋白、波形蛋白、Bcl-2、p-PI3K和p-AKT水平降低,裂解的Caspase-3、Bax和E-钙粘蛋白水平升高。此外,抑制 PIK3R6 会阻碍肿瘤生长。这些研究结果表明,PIK3R6 在 CCRCC 细胞增殖和转移过程中发挥着重要作用,是一个潜在的治疗靶点。
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引用次数: 0
JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties. JNK3 抑制剂是一种具有神经保护特性的有前途的药物。
IF 3.2 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI: 10.1080/19336918.2024.2316576
Yibeini Wu, Yiling Zhao, Ziman Guan, Sajjad Esmaeili, Zhicheng Xiao, Diji Kuriakose

The intensive study and investigation of neuroprotective therapy for central nervous system (CNS) diseases is ongoing. Due to shared mechanisms of neurodegeneration, a neuroprotective approach might offer benefits across multiple neurological disorders, despite variations in symptoms or injuries. C-Jun N-terminal Kinase 3 (JNK3) is found primarily in the CNS and is involved in physiological processes such as brain development, synapse formation, and memory formation. The potential of JNK3 as a target for pharmacological development holds promise for advancing neuroprotective therapies. Developing small molecule JNK3 inhibitors into drugs with neuroprotective qualities could facilitate neuronal restoration and self-repair. This review focuses on elucidating key neuroprotective mechanisms, exploring the interplay between neurodegenerative diseases and neuroprotection, and discussing advancements in JNK3 inhibitor drug development.

针对中枢神经系统(CNS)疾病的神经保护疗法的深入研究和调查正在进行中。由于神经变性的机制相同,尽管症状或损伤各不相同,但神经保护方法可能会给多种神经系统疾病带来益处。C-Jun N-terminal Kinase 3(JNK3)主要存在于中枢神经系统,参与大脑发育、突触形成和记忆形成等生理过程。JNK3 作为药理开发靶点的潜力为推进神经保护疗法带来了希望。将小分子 JNK3 抑制剂开发成具有神经保护特性的药物可促进神经元的恢复和自我修复。本综述将重点阐明关键的神经保护机制,探讨神经退行性疾病与神经保护之间的相互作用,并讨论 JNK3 抑制剂药物开发的进展。
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引用次数: 0
The relationship between endoplasmic reticulum stress and apoptosis in the process of adipose-derived stromal cells differentiating into astrocytes. 脂肪基质细胞分化为星形胶质细胞过程中内质网应激与细胞凋亡之间的关系
IF 3.3 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1080/19336918.2024.2430561
Pingshu Zhang, Wen Li, Ya Ou, Qi Yan, Qi Wu, Xiaodong Yuan

The potential of adult adipose-derived stromal cells (ADSCs) to differentiate into astrocytes holds promise for future cell transplantation therapies. However, the growth of differentiated astrocytes is unstable, and their survival rate is low. Endoplasmic reticulum (ER) pathway mediated apoptosis is one of the causes of cell death, but whether there is ER stress response in the differentiation of ADSCs into astrocytes is still unclear. In this study, the expression of protein factors related to endoplasmic reticulum stress (ERS) and apoptosis, including GRP78, ATF6, PERK, CHOP, Caspase12, and Caspase3, was detected in cells. It was found that the expression of ERS pro-survival factors was highest in the ADSCs group and decreased with prolonged induction time. Conversely, the expression levels of pro-apoptotic factors increased with the extension of induction time. Thus, ERS occurs during the differentiation of ADSCs into astrocytes, and ERS can mediate apoptosis of ADSC-derived astrocytes.

成体脂肪源性基质细胞(ADSCs)具有分化成星形胶质细胞的潜力,这为未来的细胞移植疗法带来了希望。然而,分化后的星形胶质细胞生长不稳定,存活率低。内质网(ER)通路介导的细胞凋亡是细胞死亡的原因之一,但 ADSCs 分化为星形胶质细胞的过程中是否存在 ER 应激反应仍不清楚。本研究检测了细胞中与内质网应激(ERS)和细胞凋亡相关的蛋白因子的表达,包括GRP78、ATF6、PERK、CHOP、Caspase12和Caspase3。结果发现,ADSCs 组中 ERS 促生存因子的表达量最高,并随着诱导时间的延长而降低。相反,促凋亡因子的表达水平随着诱导时间的延长而增加。因此,ERS发生在ADSCs向星形胶质细胞分化的过程中,并且ERS可以介导ADSCs衍生的星形胶质细胞的凋亡。
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引用次数: 0
Cell adhesion and migration in disease: translational and therapeutic opportunities. 疾病中的细胞粘附和迁移:转化和治疗机会。
IF 3.3 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2024-12-01 Epub Date: 2024-06-11 DOI: 10.1080/19336918.2024.2362978
Kurt Anderson, Yolanda Calle-Patino, Aleksandar Ivetic, Maddy Parsons, Ferran Valderrama, Claire Wells, Ines Anton

In September 2023 members of the cell adhesion and cell migration research community came together to share their latest research and consider how our work might be translated for clinical practice. Alongside invited speakers, selected speakers and poster presentations, the meeting also included a round table discussion of how we might overcome the challenges associated with research translation. This meeting report seeks to highlight the key outcomes of that discussion and spark interest in the cell adhesions and cell migration research community to cross the perceived valley of death and translate our work into therapeutic benefit.

2023年9月,细胞粘附和细胞迁移研究界的成员齐聚一堂,分享他们的最新研究成果,并探讨如何将我们的研究成果转化为临床实践。除了特邀发言人、精选发言人和海报展示之外,会议还就如何克服研究转化过程中遇到的挑战进行了圆桌讨论。本会议报告旨在强调讨论的主要成果,并激发细胞粘附和细胞迁移研究界的兴趣,以跨越死亡之谷,将我们的工作转化为治疗效益。
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引用次数: 0
Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin. 萘丁抑制 JNK/STAT3/NF-KB 通路介导的肺腺癌 A549 细胞迁移和克隆形成。
IF 3.3 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-29 DOI: 10.1080/19336918.2024.2418049
Zhe Lv, Yuna Du, Huiqing Zhang, Hui Fang, Yujie Guo, Lifeng Zeng, Yiguo Chen, Dan Li, Rong Li

Daphnetin, a coumarin derivative isolated from Daphne odorifera, has anti-tumor effects. The MAPK, STAT3, and NF-κB signaling pathways are closely related to the pathogenesis of lung cancer. To investigate the effect of daphnetin on anti-lung adenocarcinoma A549 cells and its mechanism. The anti-tumor effects of daphnetin on the proliferation, clone formation, migration, and invasion of A549 lung adenocarcinoma cells were investigated. The results showed that daphnetin inhibited the proliferation, colony formation, migration, and invasion of A549 cells through the MAPK/STAT3/NF-KB pathway, and mainly inhibited the clonal formation and migration of A549 cells through the JNK pathway. These results provide a new research direction and theoretical basis for the use of daphnetin in the inhibition of lung adenocarcinoma.

Daphnetin 是一种从 Daphne odorifera 中分离出来的香豆素衍生物,具有抗肿瘤作用。MAPK、STAT3 和 NF-κB 信号通路与肺癌的发病机制密切相关。为了研究水飞蓟素对肺腺癌 A549 细胞的抗肿瘤作用及其机制。研究了水飞萘素对 A549 肺腺癌细胞的增殖、克隆形成、迁移和侵袭的抗肿瘤作用。结果表明,水飞萘素通过MAPK/STAT3/NF-KB途径抑制A549细胞的增殖、克隆形成、迁移和侵袭,主要通过JNK途径抑制A549细胞的克隆形成和迁移。这些结果为水飞蓟素用于抑制肺腺癌提供了新的研究方向和理论依据。
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引用次数: 0
Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches. 利用综合生物信息学和实验方法阐明 MICAL1 在泛癌症中的作用。
IF 3.2 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2024-12-01 Epub Date: 2024-03-31 DOI: 10.1080/19336918.2024.2335682
Canxuan Li, Yunfei Xiao, Jianqiu Kong, Cong Lai, Zhiliang Chen, Zhuohang Li, Weibin Xie

Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, and prognostic value were assessed. Associations with tumor characteristics, immune factors, and drug sensitivity were explored. Enrichment analysis revealed MICAL1's involvement in metastasis, angiogenesis, metabolism, and immune pathways. Functional experiments demonstrated its impact on renal carcinoma cells. These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis.

与 CasL 1 相互作用的分子(MICAL1)是一种参与细胞运动、轴突导向、细胞骨架动力学和基因转录的重要蛋白质。这项泛癌症研究利用生物信息学和实验分析了 33 种癌症类型中的 MICAL1。研究评估了失调表达、诊断潜力和预后价值。研究还探讨了与肿瘤特征、免疫因素和药物敏感性的关联。富集分析显示,MICAL1参与了转移、血管生成、新陈代谢和免疫途径。功能实验证明了它对肾癌细胞的影响。这些发现将 MICAL1 定位为特定癌症的潜在生物标记物和治疗靶点,值得进一步研究它在癌症发病机制中的作用。
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引用次数: 0
Copine C plays a role in adhesion and streaming in Dictyostelium. Copine C 在竹荪的粘附和流变过程中发挥作用。
IF 3.3 3区 生物学 Q3 CELL BIOLOGY Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/19336918.2024.2315629
Rodney A Nichols, Amber D Ide, Cody T Morrison, Amber L Anger, Matthew J Buccilli, Cynthia K Damer

Copines are a family of calcium-dependent membrane-binding proteins. To study these proteins, anull mutant for cpnC was created in Dictyostelium, which has six copines genes (cpnA-cpnF). During development, cpnC- cells were able to aggregate, but did not form streams. Once aggregated into mounds, they formed large ring structures. cpnC- cells were less adherent to plastic substrates, but more adherent to other cells. These phenotypes correlated with changes in adhesion protein expression with decreased expression of SibA and increased expression of CsaA in developing cpnC- cells. We also measured the expression of RegA, a cAMP phosphodiesterase, and found that cpnC- cells have reduced RegA expression. The reduced RegA expression in cpnC- cells is most likely responsible for the observed phenotypes.

共价键是钙依赖性膜结合蛋白的一个家族。为了研究这些蛋白,我们在竹荪中创建了一个 cpnC 空突变体,该突变体有六个 copines 基因(cpnA-cpnF)。在发育过程中,cpnC-细胞能够聚集,但不能形成流。cpnC- 细胞对塑料基质的粘附性较低,但对其他细胞的粘附性较高。这些表型与粘附蛋白表达的变化有关,在发育中的 cpnC- 细胞中,SibA 的表达量减少,而 CsaA 的表达量增加。我们还测量了 cAMP 磷酸二酯酶 RegA 的表达,发现 cpnC- 细胞的 RegA 表达减少。cpnC- 细胞中 RegA 表达的减少很可能是导致观察到的表型的原因。
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引用次数: 0
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Cell Adhesion & Migration
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