Cumulative live birth rate of in vitro fertilization cycle via progestin-primed ovarian stimulation versus gonadotropin-releasing hormone antagonist protocol in infertile women with normal ovarian reserve: an open-label, randomized controlled trial.

IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI:10.1080/14647273.2024.2316005
Hongjuan Ye, Liya Shi, Xinxin Quan, Min Hou, Huilan Ma, Songguo Xue, Zhao Yu, Qiuju Chen, Lihua Sun
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Abstract

This study aimed to evaluate the cumulative live birth rate (cLBR) of progestin-primed ovarian stimulation (PPOS) protocol versus gonadotropin-releasing hormone antagonist (GnRH-ant) protocol for in vitro fertilization (IVF) cycle in infertile women with normal ovarian reserve (NOR). Infertile women with NOR who underwent their first IVF cycle were enrolled in an open-label randomized controlled trial. Patients were randomly assigned 1:1 to receive a freeze-all strategy with delayed embryo transfer (PPOS group, n = 174) and fresh embryo transfer first (GnRH-ant group, n = 174). The primary outcome was the cLBR per aspiration. The cLBR between the PPOS group and GnRH-ant group were comparable (55.75% vs. 52.87%, p = 0.591). A premature luteinizing hormone surge was not observed in the PPOS group, while there were six cases (3.45%) in the GnRH-ant group, but no premature ovulation in either of the groups. The pregnancy outcomes, including implantation rate, clinical pregnancy rate and miscarriage rate, were all comparable. In addition, the number of retrieved oocytes, mature oocytes and viable embryos were similar (all p > 0.05) between the two groups.

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卵巢储备功能正常的不孕妇女通过孕激素刺激卵巢与促性腺激素释放激素拮抗剂方案进行体外受精周期的累积活产率:开放标签随机对照试验。
本研究旨在评估孕激素促排卵(PPOS)方案与促性腺激素释放激素拮抗剂(GnRH-ant)方案在卵巢储备正常(NOR)的不孕妇女体外受精(IVF)周期中的累积活产率(cLBR)。首次接受体外受精周期治疗的卵巢储备正常的不孕妇女参加了一项开放标签随机对照试验。患者以1:1的比例随机分配接受全部冷冻策略,延迟胚胎移植(PPOS组,n = 174)和先进行新鲜胚胎移植(GnRH-ant组,n = 174)。主要结果是每次抽吸的 cLBR。PPOS 组和 GnRH-ant 组的 cLBR 值相当(55.75% 对 52.87%,P = 0.591)。PPOS 组未观察到黄体生成素过早激增,而 GnRH-ant 组有 6 例(3.45%),但两组均未观察到过早排卵。植入率、临床妊娠率和流产率等妊娠结果均相当。此外,两组取回的卵母细胞数、成熟卵母细胞数和存活胚胎数相似(均 p > 0.05)。
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来源期刊
Human Fertility
Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY
CiteScore
3.30
自引率
5.30%
发文量
50
期刊介绍: Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.
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