Lipid Nanovesicle Platforms for Hepatocellular Carcinoma Precision Medicine Therapeutics: Progress and Perspectives.

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Organogenesis Pub Date : 2024-12-31 Epub Date: 2024-02-15 DOI:10.1080/15476278.2024.2313696

Brandon M Lehrich, Evan R Delgado

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Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality globally. HCC is highly heterogenous with diverse etiologies leading to different driver mutations potentiating unique tumor immune microenvironments. Current therapeutic options, including immune checkpoint inhibitors and combinations, have achieved limited objective response rates for the majority of patients. Thus, a precision medicine approach is needed to tailor specific treatment options for molecular subsets of HCC patients. Lipid nanovesicle platforms, either liposome- (synthetic) or extracellular vesicle (natural)-derived present are improved drug delivery vehicles which may be modified to contain specific cargos for targeting specific tumor sites, with a natural affinity for liver with limited toxicity. This mini-review provides updates on the applications of novel lipid nanovesicle-based therapeutics for HCC precision medicine and the challenges associated with translating this therapeutic subclass from preclinical models to the clinic.

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用于肝细胞癌精准医学治疗的脂质纳米囊平台：进展与展望》。

肝细胞癌（HCC）是全球癌症相关死亡的主要原因之一。HCC 具有高度异质性，不同的病因导致不同的驱动基因突变，从而增强了独特的肿瘤免疫微环境。目前的治疗方案，包括免疫检查点抑制剂和联合疗法，对大多数患者的客观反应率有限。因此，需要一种精准医疗方法，为 HCC 患者的分子亚群量身定制特定的治疗方案。脂质纳米囊平台，无论是脂质体（合成的）还是细胞外囊（天然的），都是经过改良的给药载体，可被修饰成含有针对特定肿瘤部位的特定载体，对肝脏具有天然的亲和力，且毒性有限。这篇微型综述介绍了基于新型脂质纳米囊泡的疗法在 HCC 精准医疗中的最新应用，以及将这一治疗亚类从临床前模型转化到临床所面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.