Feline high-grade and large granular lymphocyte alimentary lymphomas treated with COP- or CHOP-based chemotherapy: A multi-centric retrospective study of 57 cases.

IF 2.3 2区农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2024-06-01 Epub Date: 2024-02-14 DOI:10.1111/vco.12965

Grégoire Bernardo Marques, Frédérique Ponce, Claire Beaudu-Lange, Jérémy Béguin, Laurie Boissy, Thomas Chavalle, Pauline Denoeux, Nicolas Diop, Livia Ferro, Franck Floch, Mathilde Lajoinie, David Sayag, Laura E Barrett, Gabriel Chamel

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Abstract

Specific data regarding outcome of cats with high-grade and large granular lymphocyte alimentary lymphoma (HGAL and LGL, respectively) treated with multi-agent chemotherapy are scarce. The aims of this multi-centric, retrospective study were to describe the outcome of cats with HGAL and LGL treated with COP- or CHOP-based chemotherapy and to identify potential prognostic factors. Cats with a cytological or histological diagnosis of HGAL or LGL lymphoma treated with COP- or CHOP-based protocol as first-line chemotherapy were included. Data regarding diagnosis, staging, treatment and follow-up were collected. Fifty-seven cats treated with CHOP (n = 37) or COP (n = 20) protocols were included. Complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD) were observed in 20%, 22%, 36% and 22% of cats, respectively, for an overall response rate of 42%. Median progression-free interval (PFI) was 148 days and overall median survival time (OST) was 131 days. Cats achieving CR, PR or SD showed significantly longer PFI (p < .01) and OST (p < .015) compared with cats with PD. Other positive prognostic factors in multi-variate analysis were rescue treatment (p < .001) and absence of lymph node involvement (p < .03). Negative prognostic factors were diffuse infiltration of the gastrointestinal tract (p = .035) and infiltration of a non-haematopoietic organ (p < .01).

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以 COP 或 CHOP 为基础的化疗治疗猫高级别和大颗粒淋巴细胞消化道淋巴瘤：对 57 例病例的多中心回顾性研究。

有关猫高级别和大颗粒淋巴细胞消化道淋巴瘤（分别为HGAL和LGL）多药化疗结果的具体数据很少。这项多中心回顾性研究的目的是描述以 COP 或 CHOP 为基础的化疗对 HGAL 和 LGL 猫的疗效，并确定潜在的预后因素。研究纳入了细胞学或组织学诊断为HGAL或LGL淋巴瘤并接受COP或CHOP方案作为一线化疗的猫。收集了有关诊断、分期、治疗和随访的数据。纳入了57只接受CHOP（37只）或COP（20只）方案治疗的猫。分别有20%、22%、36%和22%的猫出现完全应答（CR）、部分应答（PR）、疾病稳定（SD）和疾病进展（PD），总应答率为42%。无进展间隔中位数（PFI）为 148 天，总生存时间中位数（OST）为 131 天。获得 CR、PR 或 SD 的猫的无进展间隔时间明显更长（P

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来源期刊

Veterinary and comparative oncology 农林科学-兽医学

CiteScore

4.80

自引率

9.50%

发文量

审稿时长

>24 weeks

期刊介绍： Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.