Impact of in utero tobacco exposure on fetal growth: Amount of exposure and second trimester fetal growth measurements

IF 2.6 3区医学 Q3 NEUROSCIENCES Neurotoxicology and teratology Pub Date : 2024-02-13 DOI:10.1016/j.ntt.2024.107334

Beth A. Bailey, Haley Kopkau, Katherine Nadolski, Phoebe Dodge

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Abstract

Background

Research reveals small and inconsistent findings linking prenatal tobacco exposure and early fetal growth, but failure to consider confounding and amount of exposure many explain inconsistencies.

Goal

To examine whether fetal growth effects following exposure to tobacco are evident in the second trimester, specific to certain growth parameters, and dose dependent.

Methods

Participants were pregnant women (64 smokers, 100 controls) with no other drug use. Available data included background/medical information and ultrasound measurements coded as percentiles.

Results

Controlling for background differences, 10+ cig/day predicted a 10+ percentile point reduction in estimated fetal weight, femur length, head circumference, and biparietal diameter compared to non-exposed controls. Exposure to <10 cig/day predicted significant reduction in only biparietal diameter. Exposure was unrelated to abdominal circumference.

Conclusions

Results demonstrate utility of considering amount of exposure when examining/quantifying fetal growth effects, and suggest even reduction in early pregnancy smoking may positively benefit aspects of fetal development.

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宫内烟草暴露对胎儿生长的影响：接触量和第二孕期胎儿生长测量结果

背景研究揭示了产前烟草暴露与胎儿早期生长之间的微小且不一致的联系，但未能考虑混杂因素和暴露量可能是造成不一致的原因。方法参与者为未使用其他药物的孕妇（64 名吸烟者，100 名对照组）。结果控制背景差异后，与未暴露的对照组相比，每天吸烟 10 支以上可预测胎儿的估计体重、股骨长度、头围和双顶径减少 10 个百分点以上。每天吸食 10 支烟仅能预测双顶径的显著下降。结论研究结果表明，在检查/量化胎儿生长影响时，考虑暴露量是有用的，并表明即使减少孕早期吸烟也可能对胎儿的各方面发育产生积极的益处。

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来源期刊

Neurotoxicology and teratology 医学-毒理学

CiteScore

5.60

自引率

10.30%

发文量

审稿时长

58 days

期刊介绍： Neurotoxicology and Teratology provides a forum for publishing new information regarding the effects of chemical and physical agents on the developing, adult or aging nervous system. In this context, the fields of neurotoxicology and teratology include studies of agent-induced alterations of nervous system function, with a focus on behavioral outcomes and their underlying physiological and neurochemical mechanisms. The Journal publishes original, peer-reviewed Research Reports of experimental, clinical, and epidemiological studies that address the neurotoxicity and/or functional teratology of pesticides, solvents, heavy metals, nanomaterials, organometals, industrial compounds, mixtures, drugs of abuse, pharmaceuticals, animal and plant toxins, atmospheric reaction products, and physical agents such as radiation and noise. These reports include traditional mammalian neurotoxicology experiments, human studies, studies using non-mammalian animal models, and mechanistic studies in vivo or in vitro. Special Issues, Reviews, Commentaries, Meeting Reports, and Symposium Papers provide timely updates on areas that have reached a critical point of synthesis, on aspects of a scientific field undergoing rapid change, or on areas that present special methodological or interpretive problems. Theoretical Articles address concepts and potential mechanisms underlying actions of agents of interest in the nervous system. The Journal also publishes Brief Communications that concisely describe a new method, technique, apparatus, or experimental result.