Pub Date : 2025-04-13DOI: 10.1016/j.ntt.2025.107450
Monica Soni , Haiying Chen , Milton J. Cepeda , Lesley Berenson , Sydney Smith , Kim A. Anderson , Sara A. Quandt , Thomas A. Arcury , Paul J. Laurienti , Jonathan H. Burdette
Growing evidence shows that pesticide exposure contributes to numerous adverse health effects. Pesticide exposure can be especially problematic for vulnerable populations, and even more so for children in vulnerable populations who are still developing, such as Latinx children. Several studies have demonstrated the negative cognitive effects of prenatal exposure to pesticides, particularly organophosphates (OPs). We previously reported the results from a baseline study (Dobbins et al., 2022) designed to compare the cognitive abilities of 8-year-old children from rural, farmworking families and urban, non-farmworking families. We found that the children from both populations have considerable pesticide exposure, but to different chemicals. The children of farmworkers had greater exposure to OPs, while the children of non-farmworkers had greater exposure to organochlorines (OCs) and pyrethroids. Using the Weschler Intelligence Scale for Children–Fifth Edition (WISC-V), baseline analyses determined that children of non-farmworkers exhibited lower cognitive scores, specifically on the VSI (visual spatial) and VCI (verbal comprehension) indices. The current study examined the longitudinal significance of these findings in the same participants over a 2–3-year period. We present evidence that children from non-farmworking families exhibited significant declines on the FRI (fluid reasoning index) of the WISC-V. The children from farmworker families did not decline, and this longitudinal difference between the groups was significant. Our findings further suggest that these declines in FRI scores are likely due to greater cumulative OC exposure over the entire longitudinal period.
{"title":"A longitudinal study comparing the impact of pesticide exposure on cognitive abilities of Latinx children from rural farmworker and urban non-farmworker families","authors":"Monica Soni , Haiying Chen , Milton J. Cepeda , Lesley Berenson , Sydney Smith , Kim A. Anderson , Sara A. Quandt , Thomas A. Arcury , Paul J. Laurienti , Jonathan H. Burdette","doi":"10.1016/j.ntt.2025.107450","DOIUrl":"10.1016/j.ntt.2025.107450","url":null,"abstract":"<div><div>Growing evidence shows that pesticide exposure contributes to numerous adverse health effects. Pesticide exposure can be especially problematic for vulnerable populations, and even more so for children in vulnerable populations who are still developing, such as Latinx children. Several studies have demonstrated the negative cognitive effects of prenatal exposure to pesticides, particularly organophosphates (OPs). We previously reported the results from a baseline study (Dobbins et al., 2022) designed to compare the cognitive abilities of 8-year-old children from rural, farmworking families and urban, non-farmworking families. We found that the children from both populations have considerable pesticide exposure, but to different chemicals. The children of farmworkers had greater exposure to OPs, while the children of non-farmworkers had greater exposure to organochlorines (OCs) and pyrethroids. Using the Weschler Intelligence Scale for Children–Fifth Edition (WISC-V), baseline analyses determined that children of non-farmworkers exhibited lower cognitive scores, specifically on the VSI (visual spatial) and VCI (verbal comprehension) indices. The current study examined the longitudinal significance of these findings in the same participants over a 2–3-year period. We present evidence that children from non-farmworking families exhibited significant declines on the FRI (fluid reasoning index) of the WISC-V. The children from farmworker families did not decline, and this longitudinal difference between the groups was significant. Our findings further suggest that these declines in FRI scores are likely due to greater cumulative OC exposure over the entire longitudinal period.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107450"},"PeriodicalIF":2.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-04DOI: 10.1016/j.ntt.2025.107448
Elvis Cuevas, Susan M Lantz, J César Tobón-Velasco, Glenn D Newport, Qiangen Wu, Ashraf Virmani, Syed F Ali, Abel Santamaría
{"title":"Retraction notice to \"On the in vivo early toxic properties of Aβ<sub>25-35</sub> peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression\" [Neurotoxicology and Teratology 33 (2011) 288-296].","authors":"Elvis Cuevas, Susan M Lantz, J César Tobón-Velasco, Glenn D Newport, Qiangen Wu, Ashraf Virmani, Syed F Ali, Abel Santamaría","doi":"10.1016/j.ntt.2025.107448","DOIUrl":"10.1016/j.ntt.2025.107448","url":null,"abstract":"","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":" ","pages":"107448"},"PeriodicalIF":2.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-30DOI: 10.1016/j.ntt.2025.107447
Fuat Karakuş , Burak Kuzu
Dicofol (DCF) is an organochlorine pesticide that has recently been recognized as a persistent organic pollutant. This study begins by investigating the neurotoxicity of DCF and its metabolites through in silico tools. It subsequently explores the molecular mechanisms and key targets associated with DCF-induced neurotoxicity in humans by employing network toxicology, multi-level bioinformatics approaches, and molecular docking analyses. The prediction results indicate that both DCF and its metabolites can traverse the blood-brain barrier, penetrating the central nervous system, and inducing neurotoxicity. A thorough analysis has identified 56 potential targets linked to DCF-induced neurotoxicity. Gene Ontology enrichment analysis revealed significant associations with pathways related to sodium ion transmembrane transport, sodium/potassium-exchanging ATPase complexes, and P-type calcium transporter activity. Pathway enrichment analysis suggests that DCF-induced neurotoxicity arises from disruptions in ion transport via P-type ATPases. Further examination of gene-gene and protein-protein interactions, along with centrality analysis, identified 11 hub targets, including ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, and MAPK1, as key players. Notably, six of these targets are subunits of the Na+/K+-ATPase, a P-type ATPase. Molecular docking results demonstrated that DCF binds more effectively to the ATP1A3-ATP1B1 protein complex than to its natural ligand, ATP. These findings suggest that DCF may inhibit Na+/K+-ATPase through ATP1A3, resulting in an imbalance of sodium and potassium gradients and ultimately leading to neurotoxicity.
{"title":"An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans","authors":"Fuat Karakuş , Burak Kuzu","doi":"10.1016/j.ntt.2025.107447","DOIUrl":"10.1016/j.ntt.2025.107447","url":null,"abstract":"<div><div>Dicofol (DCF) is an organochlorine pesticide that has recently been recognized as a persistent organic pollutant. This study begins by investigating the neurotoxicity of DCF and its metabolites through <em>in silico</em> tools. It subsequently explores the molecular mechanisms and key targets associated with DCF-induced neurotoxicity in humans by employing network toxicology, multi-level bioinformatics approaches, and molecular docking analyses. The prediction results indicate that both DCF and its metabolites can traverse the blood-brain barrier, penetrating the central nervous system, and inducing neurotoxicity. A thorough analysis has identified 56 potential targets linked to DCF-induced neurotoxicity. Gene Ontology enrichment analysis revealed significant associations with pathways related to sodium ion transmembrane transport, sodium/potassium-exchanging ATPase complexes, and P-type calcium transporter activity. Pathway enrichment analysis suggests that DCF-induced neurotoxicity arises from disruptions in ion transport <em>via</em> P-type ATPases. Further examination of gene-gene and protein-protein interactions, along with centrality analysis, identified 11 hub targets, including ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, and MAPK1, as key players. Notably, six of these targets are subunits of the Na<sup>+</sup>/K<sup>+</sup>-ATPase, a P-type ATPase. Molecular docking results demonstrated that DCF binds more effectively to the ATP1A3-ATP1B1 protein complex than to its natural ligand, ATP. These findings suggest that DCF may inhibit Na<sup>+</sup>/K<sup>+</sup>-ATPase through ATP1A3, resulting in an imbalance of sodium and potassium gradients and ultimately leading to neurotoxicity.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107447"},"PeriodicalIF":2.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-27DOI: 10.1016/j.ntt.2025.107449
Katherine L. Guyon-Harris , Regan Carell , Montia D. Brock , Kathryn L. Humphreys , Alissa C. Huth-Bocks
Objective
Understanding parenting strengths and challenges among pregnant people in recovery from opioid use disorder supports effective intervention delivery. How parents think and feel about their child prenatally has implications for postnatal parenting. In our past work, greater use of positive compared to negative or neutral prenatal descriptors of the child during pregnancy was associated with higher sensitivity, warmth, and engagement during caregiver–infant interactions 12-months postpartum. We analyzed descriptions of the child among pregnant people in recovery compared to a non-substance using sample to further our understanding of potential parenting strengths and risks for people in recovery.
Method
Participants included pregnant people (N = 18; M age = 30.06, SD = 3.33) recruited from an outpatient substance use treatment program providing buprenorphine (recovery sample) and a comparison sample of pregnant people (N = 120; M age = 26.16, SD = 5.71) reporting high rates of economic disadvantage and intimate partner violence, but not substance use. Through a semi-structured interview, participants described the personality of the child they were pregnant with in up to five words/phrases. Each description was coded as positive, neutral, or negative.
Results
Participants in the recovery sample used a greater number of positive words on average (M = 3.5, SD = 1.4) relative to the comparison sample (M = 2.7, SD = 1.5; Cohen's d = 0.56, 95 % confidence interval: LL = 0.06, UL = 1.06). Use of negative descriptors was similar across samples.
Conclusions
Assessing how pregnant people in recovery think and feel about their developing fetus is feasible and could create opportunities for engagement in preventive parenting interventions to support healthy conceptualizations of the child.
{"title":"Exploring how pregnant people in recovery from opioid use disorder describe their child during pregnancy","authors":"Katherine L. Guyon-Harris , Regan Carell , Montia D. Brock , Kathryn L. Humphreys , Alissa C. Huth-Bocks","doi":"10.1016/j.ntt.2025.107449","DOIUrl":"10.1016/j.ntt.2025.107449","url":null,"abstract":"<div><h3>Objective</h3><div>Understanding parenting strengths and challenges among pregnant people in recovery from opioid use disorder supports effective intervention delivery. How parents think and feel about their child prenatally has implications for postnatal parenting. In our past work, greater use of positive compared to negative or neutral prenatal descriptors of the child during pregnancy was associated with higher sensitivity, warmth, and engagement during caregiver–infant interactions 12-months postpartum. We analyzed descriptions of the child among pregnant people in recovery compared to a non-substance using sample to further our understanding of potential parenting strengths and risks for people in recovery.</div></div><div><h3>Method</h3><div>Participants included pregnant people (<em>N</em> = 18; M age = 30.06, SD = 3.33) recruited from an outpatient substance use treatment program providing buprenorphine (recovery sample) and a comparison sample of pregnant people (<em>N</em> = 120; M age = 26.16, SD = 5.71) reporting high rates of economic disadvantage and intimate partner violence, but not substance use. Through a semi-structured interview, participants described the personality of the child they were pregnant with in up to five words/phrases. Each description was coded as positive, neutral, or negative.</div></div><div><h3>Results</h3><div>Participants in the recovery sample used a greater number of positive words on average (M = 3.5, SD = 1.4) relative to the comparison sample (M = 2.7, SD = 1.5; Cohen's d = 0.56, 95 % confidence interval: LL = 0.06, UL = 1.06). Use of negative descriptors was similar across samples.</div></div><div><h3>Conclusions</h3><div>Assessing how pregnant people in recovery think and feel about their developing fetus is feasible and could create opportunities for engagement in preventive parenting interventions to support healthy conceptualizations of the child.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107449"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-24DOI: 10.1016/j.ntt.2025.107446
Nicolas Murgueitio , Margaret A. Sheridan , Michelle Shipkova , Amy G. Halberstadt , Patricia T. Garrett-Peters , Cathi B. Propper
Dimensional models of early adversity propose developmental mechanisms by which threat and deprivation confer risk for psychopathology. Exposure to violent environments may influence social information processing biases, and limited access to complex learning environments might be associated with general challenges in emotion recognition. We examined associations of adversity measured early in development (6–36 months) and emotion recognition in early (72 months) and middle (96 months) childhood in a sample of 92 mother-child dyads. Low cognitive stimulation negatively predicted early childhood emotion recognition (β = −0.32, p = .01). Moreover, experiences of intimate-partner violence were associated with anger bias, but not global emotion recognition, in early (β = 0.24, p = .01), and middle (β = 0.18, p = .04) childhood. This pattern suggests that while the lack of exposure to complex learning experiences might impact children's conceptual knowledge of emotions, children who experience violence show biases that facilitate threat detection.
{"title":"Developmental impacts of deprivation and threat on emotion recognition","authors":"Nicolas Murgueitio , Margaret A. Sheridan , Michelle Shipkova , Amy G. Halberstadt , Patricia T. Garrett-Peters , Cathi B. Propper","doi":"10.1016/j.ntt.2025.107446","DOIUrl":"10.1016/j.ntt.2025.107446","url":null,"abstract":"<div><div>Dimensional models of early adversity propose developmental mechanisms by which threat and deprivation confer risk for psychopathology. Exposure to violent environments may influence social information processing biases, and limited access to complex learning environments might be associated with general challenges in emotion recognition. We examined associations of adversity measured early in development (6–36 months) and emotion recognition in early (72 months) and middle (96 months) childhood in a sample of 92 mother-child dyads. Low cognitive stimulation negatively predicted early childhood emotion recognition (β = −0.32, <em>p =</em> .01). Moreover, experiences of intimate-partner violence were associated with anger bias, but not global emotion recognition, in early (β = 0.24, <em>p =</em> .01), and middle (β = 0.18, <em>p =</em> .04) childhood. This pattern suggests that while the lack of exposure to complex learning experiences might impact children's conceptual knowledge of emotions, children who experience violence show biases that facilitate threat detection.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107446"},"PeriodicalIF":2.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-02DOI: 10.1016/j.ntt.2025.107443
Guilherme Malafaia
This correspondence provides constructive feedback on the study “Adolescent Exposure to Bisphenol A Antagonizes Androgen Regulation of Social Behavior in Male Mice” by Zhong et al. (2024). While the study attributes reductions in social play, interactions, and aggression to the antagonism of androgen-regulated pathways, we emphasize that unassessed confounding factors—such as locomotor deficits and anxiety-like behavior—may influence these outcomes. Evidence from Wang et al. (2020), Beauty et al. (2025), and Ji et al. (2023) highlights the necessity of evaluating these variables. We suggest incorporating behavioral assessments to ensure a more robust interpretation of BPA's direct effects on neurobehavioral responses.
本通信对 Zhong 等人的研究 "Adolescent Exposure to Bisphenol A Antagonizes Androgen Regulation of Social Behavior in Male Mice"（2024）提出了建设性的反馈意见。虽然该研究将社交游戏、互动和攻击行为的减少归因于雄激素调节途径的拮抗作用，但我们强调，未评估的混杂因素--如运动障碍和焦虑样行为--可能会影响这些结果。Wang 等人（2020 年）、Beauty 等人（2025 年）和 Ji 等人（2023 年）的研究都强调了评估这些变量的必要性。我们建议纳入行为评估，以确保更准确地解释双酚 A 对神经行为反应的直接影响。
{"title":"Critical considerations on the study “Adolescent exposure to bisphenol a antagonizes androgen regulation of social behavior in male mice” (Zhong et al., 2024): The importance of locomotor and anxiety assessments","authors":"Guilherme Malafaia","doi":"10.1016/j.ntt.2025.107443","DOIUrl":"10.1016/j.ntt.2025.107443","url":null,"abstract":"<div><div>This correspondence provides constructive feedback on the study “Adolescent Exposure to Bisphenol A Antagonizes Androgen Regulation of Social Behavior in Male Mice” by Zhong et al. (2024). While the study attributes reductions in social play, interactions, and aggression to the antagonism of androgen-regulated pathways, we emphasize that unassessed confounding factors—such as locomotor deficits and anxiety-like behavior—may influence these outcomes. Evidence from Wang et al. (2020), Beauty et al. (2025), and Ji et al. (2023) highlights the necessity of evaluating these variables. We suggest incorporating behavioral assessments to ensure a more robust interpretation of BPA's direct effects on neurobehavioral responses.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107443"},"PeriodicalIF":2.6,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ntt.2025.107435
Charles V. Vorhees, Adam L. Fritz, Brooke M. Gollaway, Michael T. Williams
The prevalence of attention deficit hyperactivity disorder (ADHD) is 9.8 % in U.S. children. Several variants of Latrophiln-3 (LPHN-3) are associated with ADHD. Using CRISPR/Cas9 we deleted exon 3 in rats to create a global Lphn3 knockout. These rats are hyperactive, startle hyper-reactive, impulsive, and have impaired working, spatial, and egocentric learning and memory. Deltamethrin (DLM) is a widely used pyrethroid insecticide. Several epidemiological studies report an increase in ADHD prevalence in children exposed to pyrethroids. Developmental exposure to DLM in rats results in multiple behavioral deficits. The present experiment tested whether Lphn3 disruption interacts with developmental DLM exposure. Because Lphn3−/− rats are severely impaired, we used Lphn3+/− (Hets) because they have an intermediate phenotype. Rats were treated by gavage once/day from postnatal day 6–20 with DLM resulting in four groups: Lphn3-Het + DLM (1.0 mg/kg), Lphn3-Het + Corn Oil (CO), Lphn3+/+ (wildtype: WT) + DLM, and WT + CO. From 31 litters, 19–27 offspring per genotype per treatment per sex were obtained with not more than 1 rat of each group and sex used from any one litter. Adult offspring were tested for exploration (open-field), 72-h home-cage activity, startle, novel object recognition (NOR), radial water maze (RWM), Morris water maze (MWM), and Cincinnati water maze (CWM). On MWM acquisition trials and the reversal probe trial, Lphn3-Het-DLM rats performed worse than other groups. This group also was impaired learning the CWM. No interactions were found for open-field, home-cage, startle, NOR, or RWM. The results show that the ADHD risk gene Lphn3 in combination with developmental DLM exposure has selective adverse effects compared with either factor alone.
{"title":"Gene × environment interaction between heterozygous deletion of the ADHD risk gene latrophilin-3 (adgrl3) and developmental deltamethrin exposure in Sprague Dawley rats","authors":"Charles V. Vorhees, Adam L. Fritz, Brooke M. Gollaway, Michael T. Williams","doi":"10.1016/j.ntt.2025.107435","DOIUrl":"10.1016/j.ntt.2025.107435","url":null,"abstract":"<div><div>The prevalence of attention deficit hyperactivity disorder (ADHD) is 9.8 % in U.S. children. Several variants of <em>Latrophiln-3</em> (<em>LPHN-3</em>) are associated with ADHD. Using CRISPR/Cas9 we deleted exon 3 in rats to create a global <em>Lphn3</em> knockout. These rats are hyperactive, startle hyper-reactive, impulsive, and have impaired working, spatial, and egocentric learning and memory. Deltamethrin (DLM) is a widely used pyrethroid insecticide. Several epidemiological studies report an increase in ADHD prevalence in children exposed to pyrethroids. Developmental exposure to DLM in rats results in multiple behavioral deficits. The present experiment tested whether <em>Lphn3</em> disruption interacts with developmental DLM exposure. Because Lphn3<sup>−/−</sup> rats are severely impaired, we used Lphn3<sup>+/−</sup> (Hets) because they have an intermediate phenotype. Rats were treated by gavage once/day from postnatal day 6–20 with DLM resulting in four groups: <em>Lphn3</em>-Het + DLM (1.0 mg/kg), <em>Lphn3</em>-Het + Corn Oil (CO), <em>Lphn3</em><sup>+/+</sup> (wildtype: WT) + DLM, and WT + CO. From 31 litters, 19–27 offspring per genotype per treatment per sex were obtained with not more than 1 rat of each group and sex used from any one litter. Adult offspring were tested for exploration (open-field), 72-h home-cage activity, startle, novel object recognition (NOR), radial water maze (RWM), Morris water maze (MWM), and Cincinnati water maze (CWM). On MWM acquisition trials and the reversal probe trial, <em>Lphn3</em>-Het-DLM rats performed worse than other groups. This group also was impaired learning the CWM. No interactions were found for open-field, home-cage, startle, NOR, or RWM. The results show that the ADHD risk gene <em>Lphn3</em> in combination with developmental DLM exposure has selective adverse effects compared with either factor alone.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"108 ","pages":"Article 107435"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.ntt.2025.107436
Kallio Hunnicutt-Ferguson , Susan A. Stoner , Julie A. Kable , Therese M. Grant , Claire D. Coles
Background
Substance use and mental health problems have been documented in individuals with prenatal alcohol exposure (PAE) in young adulthood, but little is known about how these patterns progress over time into midlife. The current study examined rates of substance use in a sample of adults with PAE in mid-life compared to a demographically similar contrast group.
Methods
Participants (n = 233) were drawn from two longitudinal cohorts of individuals recruited prenatally and followed into adulthood. Measures of cognition, substance use, and self-reported mental health functioning were obtained.
Results
Differences among groups (PAE no dysmorphology, PAE with dysmorphology, No PAE contrast group) were examined on demographic variables of interest and substance use outcomes. Both PAE groups experienced higher levels of Adverse Childhood Experiences (ACEs) compared to the contrast group. We also observed higher rates of current tobacco use in those with PAE; those with PAE and no dysmorphology had almost twice the rate of current tobacco use as the nonexposed contrast group. We observed similar rates of high risk drinking on the Alcohol Use Identification Test (AUDIT) in all groups. Individuals with PAE also showed high rates of cannabis use compared to national averages. Generalized linear regressions examining predictive effects of PAE on substance use outcomes did not show significant results, though female sex at birth was predictive of current cannabis use. Current alcohol use predicted depression and PTSD symptoms, and significant interactions were observed between PAE group and ACEs on depression, PTSD, anxiety, and psychotic symptoms.
Conclusion
This is one of the only studies to examine rates of alcohol and other substance use among adults in mid-life with PAE. Results suggest that relationships between PAE, substance use, and mental health symptoms are complex, and it will be important for future studies to examine factors associated with high-risk substance use among this vulnerable population.
{"title":"Substance use and mental health symptoms in adults with prenatal alcohol exposure","authors":"Kallio Hunnicutt-Ferguson , Susan A. Stoner , Julie A. Kable , Therese M. Grant , Claire D. Coles","doi":"10.1016/j.ntt.2025.107436","DOIUrl":"10.1016/j.ntt.2025.107436","url":null,"abstract":"<div><h3>Background</h3><div>Substance use and mental health problems have been documented in individuals with prenatal alcohol exposure (PAE) in young adulthood, but little is known about how these patterns progress over time into midlife. The current study examined rates of substance use in a sample of adults with PAE in mid-life compared to a demographically similar contrast group.</div></div><div><h3>Methods</h3><div>Participants (<em>n</em> = 233) were drawn from two longitudinal cohorts of individuals recruited prenatally and followed into adulthood. Measures of cognition, substance use, and self-reported mental health functioning were obtained.</div></div><div><h3>Results</h3><div>Differences among groups (PAE no dysmorphology, PAE with dysmorphology, No PAE contrast group) were examined on demographic variables of interest and substance use outcomes. Both PAE groups experienced higher levels of Adverse Childhood Experiences (ACEs) compared to the contrast group. We also observed higher rates of current tobacco use in those with PAE; those with PAE and no dysmorphology had almost twice the rate of current tobacco use as the nonexposed contrast group. We observed similar rates of high risk drinking on the Alcohol Use Identification Test (AUDIT) in all groups. Individuals with PAE also showed high rates of cannabis use compared to national averages. Generalized linear regressions examining predictive effects of PAE on substance use outcomes did not show significant results, though female sex at birth was predictive of current cannabis use. Current alcohol use predicted depression and PTSD symptoms, and significant interactions were observed between PAE group and ACEs on depression, PTSD, anxiety, and psychotic symptoms.</div></div><div><h3>Conclusion</h3><div>This is one of the only studies to examine rates of alcohol and other substance use among adults in mid-life with PAE. Results suggest that relationships between PAE, substance use, and mental health symptoms are complex, and it will be important for future studies to examine factors associated with high-risk substance use among this vulnerable population.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"109 ","pages":"Article 107436"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-14DOI: 10.1016/j.ntt.2025.107434
Sifan Xu , Qi Wang , Yu Qin, Qian Yang, Yang Xu, Zhiming Zhou
Objective
To investigate the anti-apoptosis and anti-ferroptosis effects of dl-3-n-butylphthalide (dl-NBP) on cerebral ischemia-reperfusion injury (CIRI) in rats, and the potential involvement of cysteine-X-cysteine chemokine receptor 4 (CXCR4).
Methods
The differentially expressed genes between healthy people and stroke patients were screened by GEO database. A transient middle cerebral artery occlusion rat model was used to induce CIRI in vivo. Rats were randomly divided into sham group, tMCAO group, and dl-NBP + tMCAO group. The therapeutic effect of dl-NBP in vivo and its effect on apoptosis and ferroptosis in brain tissues were evaluated. An in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model was established to simulate CIRI in cultured PC12 cells, and the effects of dl-NBP on apoptosis and ferroptosis were examined. In this model, CXCR4 expression was assessed by western blotting and its involvement in dl-NBP-mediated protection assessed by inhibition with AMD3100.
Results
In the stroke-related GSE22255 and GSE66724 datasets, a total of six genes with increased co-expression were found, including CXCR4. Dl-NBP treatment significantly reduced both the volume of cerebral infarction and the degree of cerebral edema, and improved neurological function in rats. dl-NBP reduced the degree of apoptosis and ferroptosis and alleviated CIRI both in vivo and in vitro. The pro-survival effects of dl-NBP were significantly reversed after CXCR4 inhibition with AMD3100.
Conclusion
Dl-NBP has anti-apoptotic and anti-ferroptotic effects on CIRI both in vivo and in vitro, and this effect is mediated by CXCR4.
{"title":"Dl-3-n-butylphthalein inhibits neuronal apoptosis and ferroptosis after cerebral ischemia-reperfusion injury in rats by regulating CXCR4","authors":"Sifan Xu , Qi Wang , Yu Qin, Qian Yang, Yang Xu, Zhiming Zhou","doi":"10.1016/j.ntt.2025.107434","DOIUrl":"10.1016/j.ntt.2025.107434","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the anti-apoptosis and anti-ferroptosis effects of dl-3-n-butylphthalide (dl-NBP) on cerebral ischemia-reperfusion injury (CIRI) in rats, and the potential involvement of cysteine-X-cysteine chemokine receptor 4 (CXCR4).</div></div><div><h3>Methods</h3><div>The differentially expressed genes between healthy people and stroke patients were screened by GEO database. A transient middle cerebral artery occlusion rat model was used to induce CIRI in vivo. Rats were randomly divided into sham group, tMCAO group, and dl-NBP + tMCAO group. The therapeutic effect of dl-NBP in vivo and its effect on apoptosis and ferroptosis in brain tissues were evaluated. An in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model was established to simulate CIRI in cultured PC12 cells, and the effects of dl-NBP on apoptosis and ferroptosis were examined. In this model, CXCR4 expression was assessed by western blotting and its involvement in dl-NBP-mediated protection assessed by inhibition with AMD3100.</div></div><div><h3>Results</h3><div>In the stroke-related GSE22255 and GSE66724 datasets, a total of six genes with increased co-expression were found, including CXCR4. Dl-NBP treatment significantly reduced both the volume of cerebral infarction and the degree of cerebral edema, and improved neurological function in rats. dl-NBP reduced the degree of apoptosis and ferroptosis and alleviated CIRI both in vivo and in vitro. The pro-survival effects of dl-NBP were significantly reversed after CXCR4 inhibition with AMD3100.</div></div><div><h3>Conclusion</h3><div>Dl-NBP has anti-apoptotic and anti-ferroptotic effects on CIRI both in vivo and in vitro, and this effect is mediated by CXCR4.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"108 ","pages":"Article 107434"},"PeriodicalIF":2.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-08DOI: 10.1016/j.ntt.2025.107433
Isabel R. Aks , Herry Patel , William E. Pelham III , Marilyn A. Huestis , Natasha E. Wade
<div><h3>Background</h3><div>Cannabis is one of the most widely used drugs in early adolescence, a crucial time for development. Cannabinoids within the cannabis plant (e.g., delta-9-tetrahydrocannabinol [THC], and cannabidiol [CBD]) are suggested to have a range of health implications. These may differ by sex, given sex differences in the endocannabinoid system (ECS). Yet, how aspects of mental and physical health are related to cannabis use as measured by hair concentrations, both within early adolescence and across sexes, is so far inconclusive.</div></div><div><h3>Methods</h3><div>We analyzed hair toxicology data from three cannabinoid analytes (THC, CBD, and 11-nor-9-carboxy-THC [THCCOOH]) and multiple mental and physical health measures in 9–15 year-old youth (49 % female) from the Adolescent Brain Cognitive Development (ABCD) Study (<em>N</em> = 2262). Two-part linear regression models were fit to assess the effects of cannabis constituent presence, concentrations, and THC concentrations + CBD presence on externalizing and internalizing symptoms, physical and strengthening exercise, asthma presence, and sleep duration. Secondary analyses fit the same models but stratified by sex. Finally, to further characterize these relationships, we conducted two exploratory analyses: we assessed health variables prospectively and concurrently predicting cannabinoid concentrations. False discovery rate corrections were employed for all analyses.</div></div><div><h3>Results</h3><div>In the full sample, greater THC concentrations predicted more frequent strength exercise one year later; greater CBD concentrations predicted fewer strength exercise days; and greater THCCOOH concentrations predicted shorter sleep duration. Among males, cannabinoids differentially predicted exercise days; greater THC and THCCOOH concentrations predicted shorter sleep duration. Among females, greater THC and THCCOOH concentrations predicted strength exercise frequency, and THC concentrations predicted shorter sleep duration. In exploratory models, asthma presence predicted THCCOOH concentration one year later. Concurrently, THC concentration alone and in the presence of CBD predicted both sleep duration and lower exercise days, while THCCOOH concentration predicted lower exercise days, less asthma presence, as well as greater internalizing and externalizing symptoms.</div></div><div><h3>Conclusion</h3><div>In a nationwide study of youth ages 9–15 years old, we found cannabinoid hair concentrations predicted differences in health outcomes a year later, suggesting potential differential mechanisms for THC and CBD effects on health. Furthermore, sex-specific observations in these prospective associations emphasize the importance of considering sex assigned at birth when investigating correlates of cannabis use. Analysis of cannabinoid hair concentrations can reveal key links to mental health, physical activity, and sleep, aiding understanding of complex cannabis effects.</div></d
{"title":"Cannabinoids in hair and their prospective association with mental and physical health outcomes in adolescents","authors":"Isabel R. Aks , Herry Patel , William E. Pelham III , Marilyn A. Huestis , Natasha E. Wade","doi":"10.1016/j.ntt.2025.107433","DOIUrl":"10.1016/j.ntt.2025.107433","url":null,"abstract":"<div><h3>Background</h3><div>Cannabis is one of the most widely used drugs in early adolescence, a crucial time for development. Cannabinoids within the cannabis plant (e.g., delta-9-tetrahydrocannabinol [THC], and cannabidiol [CBD]) are suggested to have a range of health implications. These may differ by sex, given sex differences in the endocannabinoid system (ECS). Yet, how aspects of mental and physical health are related to cannabis use as measured by hair concentrations, both within early adolescence and across sexes, is so far inconclusive.</div></div><div><h3>Methods</h3><div>We analyzed hair toxicology data from three cannabinoid analytes (THC, CBD, and 11-nor-9-carboxy-THC [THCCOOH]) and multiple mental and physical health measures in 9–15 year-old youth (49 % female) from the Adolescent Brain Cognitive Development (ABCD) Study (<em>N</em> = 2262). Two-part linear regression models were fit to assess the effects of cannabis constituent presence, concentrations, and THC concentrations + CBD presence on externalizing and internalizing symptoms, physical and strengthening exercise, asthma presence, and sleep duration. Secondary analyses fit the same models but stratified by sex. Finally, to further characterize these relationships, we conducted two exploratory analyses: we assessed health variables prospectively and concurrently predicting cannabinoid concentrations. False discovery rate corrections were employed for all analyses.</div></div><div><h3>Results</h3><div>In the full sample, greater THC concentrations predicted more frequent strength exercise one year later; greater CBD concentrations predicted fewer strength exercise days; and greater THCCOOH concentrations predicted shorter sleep duration. Among males, cannabinoids differentially predicted exercise days; greater THC and THCCOOH concentrations predicted shorter sleep duration. Among females, greater THC and THCCOOH concentrations predicted strength exercise frequency, and THC concentrations predicted shorter sleep duration. In exploratory models, asthma presence predicted THCCOOH concentration one year later. Concurrently, THC concentration alone and in the presence of CBD predicted both sleep duration and lower exercise days, while THCCOOH concentration predicted lower exercise days, less asthma presence, as well as greater internalizing and externalizing symptoms.</div></div><div><h3>Conclusion</h3><div>In a nationwide study of youth ages 9–15 years old, we found cannabinoid hair concentrations predicted differences in health outcomes a year later, suggesting potential differential mechanisms for THC and CBD effects on health. Furthermore, sex-specific observations in these prospective associations emphasize the importance of considering sex assigned at birth when investigating correlates of cannabis use. Analysis of cannabinoid hair concentrations can reveal key links to mental health, physical activity, and sleep, aiding understanding of complex cannabis effects.</div></d","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"108 ","pages":"Article 107433"},"PeriodicalIF":2.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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