Neurotoxicology and teratology最新文献

Dl-3-n-butylphthalein inhibits neuronal apoptosis and ferroptosis after cerebral ischemia-reperfusion injury in rats by regulating CXCR4.

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-02-14 DOI: 10.1016/j.ntt.2025.107434

Sifan Xu, Qi Wang, Yu Qin, Qian Yang, Yang Xu, Zhiming Zhou

Objective: To investigate the anti-apoptosis and anti-ferroptosis effects of dl-3-n-butylphthalide (dl-NBP) on cerebral ischemia-reperfusion injury (CIRI) in rats, and the potential involvement of cysteine-X-cysteine chemokine receptor 4 (CXCR4).

Methods: The differentially expressed genes between healthy people and stroke patients were screened by GEO database. A transient middle cerebral artery occlusion rat model was used to induce CIRI in vivo. Rats were randomly divided into sham group, tMCAO group, and dl-NBP + tMCAO group. The therapeutic effect of dl-NBP in vivo and its effect on apoptosis and ferroptosis in brain tissues were evaluated. An in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model was established to simulate CIRI in cultured PC12 cells, and the effects of dl-NBP on apoptosis and ferroptosis were examined. In this model, CXCR4 expression was assessed by western blotting and its involvement in dl-NBP-mediated protection assessed by inhibition with AMD3100.

Results: In the stroke-related GSE22255 and GSE66724 datasets, a total of six genes with increased co-expression were found, including CXCR4. Dl-NBP treatment significantly reduced both the volume of cerebral infarction and the degree of cerebral edema, and improved neurological function in rats. dl-NBP reduced the degree of apoptosis and ferroptosis and alleviated CIRI both in vivo and in vitro. The pro-survival effects of dl-NBP were significantly reversed after CXCR4 inhibition with AMD3100.

Conclusion: Dl-NBP has anti-apoptotic and anti-ferroptotic effects on CIRI both in vivo and in vitro, and this effect is mediated by CXCR4.

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引用次数: 0

Cannabinoids in hair and their prospective association with mental and physical health outcomes in adolescents.

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-02-08 DOI: 10.1016/j.ntt.2025.107433

Isabel R Aks, Herry Patel, William E Pelham, Marilyn A Huestis, Natasha E Wade

Background: Cannabis is one of the most widely used drugs in early adolescence, a crucial time for development. Cannabinoids within the cannabis plant (e.g., delta-9-tetrahydrocannabinol [THC], and cannabidiol [CBD]) are suggested to have a range of health implications. These may differ by sex, given sex differences in the endocannabinoid system (ECS). Yet, how aspects of mental and physical health are related to cannabis use as measured by hair concentrations, both within early adolescence and across sexes, is so far inconclusive.

Methods: We analyzed hair toxicology data from three cannabinoid analytes (THC, CBD, and 11-nor-9-carboxy-THC [THCCOOH]) and multiple mental and physical health measures in 9-15 year-old youth (49 % female) from the Adolescent Brain Cognitive Development (ABCD) Study (N = 2262). Two-part linear regression models were fit to assess the effects of cannabis constituent presence, concentrations, and THC concentrations + CBD presence on externalizing and internalizing symptoms, physical and strengthening exercise, asthma presence, and sleep duration. Secondary analyses fit the same models but stratified by sex. Finally, to further characterize these relationships, we conducted two exploratory analyses: we assessed health variables prospectively and concurrently predicting cannabinoid concentrations. False discovery rate corrections were employed for all analyses.

Results: In the full sample, greater THC concentrations predicted more frequent strength exercise one year later; greater CBD concentrations predicted fewer strength exercise days; and greater THCCOOH concentrations predicted shorter sleep duration. Among males, cannabinoids differentially predicted exercise days; greater THC and THCCOOH concentrations predicted shorter sleep duration. Among females, greater THC and THCCOOH concentrations predicted strength exercise frequency, and THC concentrations predicted shorter sleep duration. In exploratory models, asthma presence predicted THCCOOH concentration one year later. Concurrently, THC concentration alone and in the presence of CBD predicted both sleep duration and lower exercise days, while THCCOOH concentration predicted lower exercise days, less asthma presence, as well as greater internalizing and externalizing symptoms.

Conclusion: In a nationwide study of youth ages 9-15 years old, we found cannabinoid hair concentrations predicted differences in health outcomes a year later, suggesting potential differential mechanisms for THC and CBD effects on health. Furthermore, sex-specific observations in these prospective associations emphasize the importance of considering sex assigned at birth when investigating correlates of cannabis use. Analysis of cannabinoid hair concentrations can reveal key links to mental health, physical activity, and sleep, aiding understanding of complex cannabis effects.

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引用次数: 0

Tricresylphosphate isomers: A review of toxicity pathways

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-02-06 DOI: 10.1016/j.ntt.2025.107432

Marta Tkachuk, Nataliya Matiytsiv

Synthetiс organophosphates are a large group of chemicals, annually produced by an industry with their further application as oil additives, flame retardants, plasticizers, warfare agents and insecticides for domestic use and in the control of vector-borne diseases. Consequently, organophosphates are often detected in the environment and human samples, which can have adverse effects on ecosystems and human health. This review aimed to summarize recent findings about different aspects of tricresyl phosphate mixture and separate isomers toxicity, including their impact on nervous, endocrine, and reproductive systems studied in animal models or in vitro. We also discuss the underlying molecular and cellular mechanisms involved in these processes, which comprise inhibition of neuropathy target esterase (NTE), overactivation of neuregulin1/ErbB and MAPK signaling pathways, impairment of glutamate signaling as well as interaction with nuclear hormone. Finally, we outline potential therapeutic targets and promising agents as important directions for future research.

引用次数: 0

Associations of prenatal maternal psychosocial stress and depression with neurodevelopmental outcomes in 7.5-month-old infants in the ECHO.CA.IL prospective birth cohorts 产前母亲心理社会压力和抑郁与7.5月龄婴儿神经发育结局的关系

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-01-10 DOI: 10.1016/j.ntt.2025.107431

Nicholas Cragoe , Jenna Sprowles , Stephanie M. Eick , Lynn Harvey , Xavier R. Ramirez , Gloria Arroyo Sugg , Rachel Morello-Frosch , Tracey Woodruff , Susan L. Schantz

Background

Exposure to maternal stress and depression during pregnancy can have a marked impact on birth outcomes and child development, escalating the likelihood of preterm birth, lower birth weight, and various domains of physical and neurodevelopment.

Methods

The joint ECHO.CA.IL cohort is comprised of the Chemicals in Our Bodies (CIOB) and Illinois Kids Development Study (IKIDS) prospective cohorts, recruiting pregnant women in San Francisco, CA, and Urbana-Champaign, IL, respectively. Using a combined sample of 428 mother-infant dyads, we examined associations between two prenatal measures of maternal stress (perceived stress (PSS) and stressful events (SLE)), as well as maternal depression, and five domains of neurodevelopment via the Ages & Stages Questionnaire (ASQ) administered at 7.5 months. Linear regression models were adjusted for relevant demographic characteristics and used to identify patterns of association.

Results

CIOB mothers were comparatively racially/ethnically diverse (52 % white, 28 % Asian American/Pacific Islander, 12 % Hispanic), while IKIDS mothers were disproportionately white (80 %). Both cohorts demonstrated high levels of maternal education and were similar in terms of other demographic characteristics. CIOB mothers reported higher levels of stress (e.g., SLE: 49.63 % report ≥1 event) compared to IKIDS mothers (e.g., SLE: 16.34 % report ≥1 event). In adjusted linear models, patterns of association were nearly uniformly negative between stress and ASQ measures, with associations between PSS and fine motor skills (β-0.26, CI = -0.52; 0.00) and SLEs and communication skills (β = −2.9245, CI = -6.1643; 0.3152) showing the strongest associations (p < 0.1). Depression showed no significant or clear pattern of association with ASQ scores.

Conclusion

This study found negative associations between prenatal maternal stress and infant neurodevelopment in the combined ECHO.CA.IL cohort, suggesting that prenatal stress is associated with delayed development of motor and communication skills during infancy. The inconclusive links between maternal depression and ASQ outcomes leave open the question regarding the influence of prenatal depression on early child neurodevelopment.

背景：在怀孕期间暴露于母亲的压力和抑郁会对出生结果和儿童发育产生显著影响，增加早产、低出生体重的可能性，以及身体和神经发育的各个领域。方法：联合ECHO.CA.IL队列由我们体内的化学物质（CIOB）和伊利诺斯州儿童发展研究（IKIDS）前瞻性队列组成，分别在加州旧金山和伊利诺斯州厄巴纳-香槟招募孕妇。使用428对母婴组合样本，我们通过7.5 个月的年龄和阶段问卷（ASQ）检查了母亲压力的两种产前测量（感知压力（PSS）和压力事件（SLE））以及母亲抑郁与神经发育的五个领域之间的关联。线性回归模型根据相关的人口统计学特征进行调整，并用于确定关联模式。结果：CIOB母亲的种族/民族相对多样化（52% %为白人，28% %为亚裔美国人/太平洋岛民，12% %为西班牙裔），而IKIDS母亲的白人比例过高（80% %）。两个队列都显示出高水平的母亲教育，并且在其他人口统计学特征方面相似。与IKIDS母亲（sle: 16.34 %报告≥1个事件）相比，CIOB母亲报告的压力水平更高（例如，sle: 49.63 %报告≥1个事件）。在调整后的线性模型中，压力与ASQ测量之间的关联模式几乎一致为负，PSS与精细运动技能之间存在关联(β-0.26, CI = -0.52；0.00)、SLEs和沟通能力(β = -2.9245,CI = -6.1643；结论：本研究发现，在ECHO.CA.IL联合队列中，产前母亲压力与婴儿神经发育呈负相关，提示产前压力与婴儿运动和沟通技能发育迟缓有关。母亲抑郁和ASQ结果之间不确定的联系留下了关于产前抑郁对儿童早期神经发育影响的问题。

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引用次数: 0

Transplacental signals involved in the programming effects of prenatal psychosocial stress on neurodevelopment 经胎盘信号参与产前社会心理应激对神经发育的编程效应。

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-01-01 DOI: 10.1016/j.ntt.2025.107424

Sandra P. Zoubovsky , Louis J. Muglia

Exposure to psychosocial stress during pregnancy has been associated with the emergence of neurodevelopmental and neuropsychiatric disorders in offspring. The placenta is known to orchestrate various functions that are essential for normal fetal development, including the brain. It has therefore been postulated that alterations in such functions, and downstream signaling, have the potential to dramatically affect brain developmental trajectories and contribute to adverse neurodevelopmental outcomes. This review will focus on discussing various placental functions that have been proposed to be affected by exposure to prenatal psychosocial stress and the implications of such disruptions on long-term neurodevelopmental programming.

怀孕期间暴露于社会心理压力与后代出现神经发育和神经精神障碍有关。众所周知，胎盘协调各种对胎儿正常发育至关重要的功能，包括大脑。因此，这些功能和下游信号的改变有可能显著影响大脑发育轨迹，并导致不利的神经发育结果。这篇综述将集中讨论各种胎盘功能，这些功能已被提出受到产前社会心理压力的影响，以及这种破坏对长期神经发育程序的影响。

引用次数: 0

Earlier pubertal timing, not tempo, links time-limited early adversity with psychopathology 较早的青春期时间，而不是节奏，将有限的早期逆境与精神病理联系起来。

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-01-01 DOI: 10.1016/j.ntt.2024.107420

Mariann A. Howland , Brie M. Reid , Bonny Donzella , Megan R. Gunnar

Evolutionary-developmental theories propose that early adverse experiences adaptively shift the timing (i.e., onset) and tempo (i.e., rate) of pubertal maturation. Empirical evidence of links between early life adversity and pubertal maturation is mixed, potentially in part because isolating the unique impacts of early environments is challenging. The current accelerated longitudinal study used a quasi-experimental design to examine pubertal maturation among 132 previously-institutionalized (PI), internationally adopted children who experienced a time-limited form of severe early life adversity, compared to 169 non-adopted (NA) children. Based on prior literature, we also assessed whether pubertal timing and/or tempo are pathways by which early adversity relates to later symptoms of psychopathology. At each of three annual sessions, Tanner pubertal staging was determined by nurse exam, and symptoms of psychopathology were captured in a composite of child self-reported internalizing and parent-reported externalizing symptoms. Findings revealed that, only among children at Tanner pubertal stages 3 or below, PI children were more likely to have reached stage 3 compared to NA children, reflective of earlier pubertal timing. No group differences were found for pubertal tempo. In the subsample of children at Tanner stage 3 or lower, earlier pubertal timing was an indirect pathway by which early adversity related to both higher levels and greater longitudinal declines in internalizing and externalizing symptoms of psychopathology, accounting for a small proportion of the total effect of early adversity on psychopathology. Results from this quasi-experimental study add to existing research on associations between early adversity, early pubertal timing, and psychopathology, further suggesting that links may be specific to timing but not tempo. While findings broadly align with recent calls to consider early pubertal maturation as a transdiagnostic risk marker with utility for identifying children who could benefit from early mental health intervention, they also suggest that pubertal timing is unlikely to be a robust target for reducing psychopathology risk in these children.

进化发展理论认为，早期的不良经历适应性地改变了青春期成熟的时间（即开始）和速度（即速度）。早期生活逆境与青春期成熟之间联系的经验证据好坏参半，可能部分原因是孤立早期环境的独特影响是具有挑战性的。当前的加速纵向研究采用准实验设计来检查132名以前被收容（PI）的国际收养儿童的青春期成熟度，这些儿童经历了一段时间的严重早期生活逆境，与169名非收养（NA）儿童进行了比较。基于先前的文献，我们也评估了青春期的时间和/或节奏是否是早期逆境与后来的精神病理症状相关的途径。在每年三次的会议中，坦纳青春期分期由护士检查确定，精神病理症状由儿童自我报告的内化症状和父母报告的外化症状组成。研究结果显示，只有在Tanner青春期第3阶段或以下的儿童中，PI儿童比NA儿童更有可能达到第3阶段，这反映了早期的青春期时间。青春期发育速度无组间差异。在Tanner阶段3或更低的儿童子样本中，较早的青春期时间是一个间接途径，通过该途径，早期逆境与精神病理学内在化和外在化症状的较高水平和较大的纵向下降相关，占早期逆境对精神病理学总影响的一小部分。这项准实验研究的结果为现有的关于早期逆境、青春期早期时间和精神病理之间关系的研究提供了补充，进一步表明这种联系可能只与时间有关，而与速度无关。虽然研究结果与最近的呼吁大体一致，即将青春期早期成熟作为一种跨诊断风险标记，用于识别可能从早期心理健康干预中受益的儿童，但它们也表明，青春期时间不太可能是降低这些儿童精神病理风险的有力目标。

{"title":"Earlier pubertal timing, not tempo, links time-limited early adversity with psychopathology","authors":"Mariann A. Howland , Brie M. Reid , Bonny Donzella , Megan R. Gunnar","doi":"10.1016/j.ntt.2024.107420","DOIUrl":"10.1016/j.ntt.2024.107420","url":null,"abstract":"<div><div>Evolutionary-developmental theories propose that early adverse experiences adaptively shift the timing (i.e., onset) and tempo (i.e., rate) of pubertal maturation. Empirical evidence of links between early life adversity and pubertal maturation is mixed, potentially in part because isolating the unique impacts of early environments is challenging. The current accelerated longitudinal study used a quasi-experimental design to examine pubertal maturation among 132 previously-institutionalized (PI), internationally adopted children who experienced a time-limited form of severe early life adversity, compared to 169 non-adopted (NA) children. Based on prior literature, we also assessed whether pubertal timing and/or tempo are pathways by which early adversity relates to later symptoms of psychopathology. At each of three annual sessions, Tanner pubertal staging was determined by nurse exam, and symptoms of psychopathology were captured in a composite of child self-reported internalizing and parent-reported externalizing symptoms. Findings revealed that, only among children at Tanner pubertal stages 3 or below, PI children were more likely to have reached stage 3 compared to NA children, reflective of earlier pubertal timing. No group differences were found for pubertal tempo. In the subsample of children at Tanner stage 3 or lower, earlier pubertal timing was an indirect pathway by which early adversity related to both higher levels and greater longitudinal declines in internalizing and externalizing symptoms of psychopathology, accounting for a small proportion of the total effect of early adversity on psychopathology. Results from this quasi-experimental study add to existing research on associations between early adversity, early pubertal timing, and psychopathology, further suggesting that links may be specific to timing but not tempo. While findings broadly align with recent calls to consider early pubertal maturation as a transdiagnostic risk marker with utility for identifying children who could benefit from early mental health intervention, they also suggest that pubertal timing is unlikely to be a robust target for reducing psychopathology risk in these children.</div></div>","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":"107 ","pages":"Article 107420"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study 产前咖啡因暴露与儿童发育之间的关系：青少年大脑认知发展（ABCD）研究的纵向结果。

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-01-01 DOI: 10.1016/j.ntt.2024.107404

Hailey Modi , David A.A. Baranger , Sarah E. Paul , Aaron J. Gorelik , Alana Hornstein , Jared V. Balbona , Arpana Agrawal , Janine D. Bijsterbosch , Ryan Bogdan

Objective

Though caffeine use during pregnancy is common, its longitudinal associations with child behavioral and physical health outcomes remain poorly understood. Here, we estimated associations between prenatal caffeine exposure, body mass index (BMI), and behavior as children enter adolescence.

Method

Longitudinal data and caregiver-reported prenatal caffeine exposure were obtained from the ongoing Adolescent Brain and Cognitive Development (ABCD)^SM Study, which recruited 11,875 children aged 9–11 years at baseline from 21 sites across the United States starting June 1, 2016. Prenatal caffeine exposure was analyzed as a 4-level categorical variable, and further group contrasts were used to characterize “any exposure” and “daily exposure” groups. Outcomes included psychopathology characteristics in children, sleep problems, and BMI. Potentially confounding covariates included familial (e.g., income, familial psychopathology), pregnancy (e.g., prenatal substance exposure), and child (e.g., caffeine use) variables.

Results

Among 10,873 children (5686 boys [52.3 %]; mean [SD] age, 9.9 [0.6] years) with nonmissing prenatal caffeine exposure data, 6560 (60 %) were exposed to caffeine prenatally. Relative to no exposure, daily caffeine exposure was associated with higher child BMI (β = 0.08; FDR-corrected p = 0.02), but was not associated with child behavior following correction for multiple testing. Those exposed to two or more cups of caffeine daily (n = 1028) had greater sleep problems than those with lower/no exposure (β > 0.92; FDR-corrected p < 0.04).

Conclusion

Daily prenatal caffeine exposure is associated with heightened childhood BMI, and when used multiple times a day greater sleep problems even after accounting for potential confounds. Whether this relationship is a consequence of prenatal caffeine exposure or its correlated factors remains unknown.

目的：虽然孕期使用咖啡因很常见，但人们对咖啡因与儿童行为和身体健康结果的纵向关系仍然知之甚少。在此，我们估算了产前咖啡因暴露、体重指数（BMI）和儿童进入青春期后的行为之间的关系：纵向数据和护理人员报告的产前咖啡因暴露来自正在进行的青少年大脑和认知发展（ABCD）SM 研究，该研究从 2016 年 6 月 1 日开始在全美 21 个地点招募了 11,875 名基线年龄为 9-11 岁的儿童。产前咖啡因暴露作为一个四级分类变量进行分析，并进一步进行分组对比，以确定 "任何暴露 "组和 "每日暴露 "组的特征。研究结果包括儿童心理病理学特征、睡眠问题和体重指数。潜在的混杂协变量包括家庭（如收入、家庭精神病理学）、妊娠（如产前药物暴露）和儿童（如咖啡因使用）变量：在产前咖啡因暴露数据无遗漏的10873名儿童（5686名男孩[52.3%]；平均[SD]年龄为9.9[0.6]岁）中，有6560名儿童（60%）在产前接触过咖啡因。与未接触咖啡因相比，每天接触咖啡因与儿童较高的体重指数相关（β = 0.08；经FDR校正后p = 0.02），但经多重检验校正后与儿童行为无关。每天摄入两杯或两杯以上咖啡因的人（n = 1028）比摄入较少/未摄入咖啡因的人有更多的睡眠问题（β > 0.92；FDR校正后的p 结论：与其他儿童相比，每天摄入两杯或两杯以上咖啡因的人（n = 1028）有更多的睡眠问题：即使考虑了潜在的混杂因素，产前每日摄入咖啡因与儿童体重指数（BMI）升高有关，如果每天多次摄入咖啡因，睡眠问题会更严重。这种关系是否是产前咖啡因暴露或其相关因素造成的，目前仍不得而知。

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引用次数: 0

The effects of developmental sub-chronic low-level lead exposure on microglia and a test of possible mitigation by apigenin in C57BL/6J young mice 发育亚慢性低水平铅暴露对C57BL/6/J幼鼠小胶质细胞的影响及芹菜素可能缓解作用的试验

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-01-01 DOI: 10.1016/j.ntt.2024.107406

Gisel Flores-Montoya, Zichen Tian, Ayasa Michii, Sze Ying Chan, Natalie Sanchez

Developmental chronic low-level lead (Pb) exposure disrupts central nervous system function and diminishes neurocognition. Microglial cell activation might contribute to these deficits. The present study evaluated the effects of developmental sub-chronic low-level lead exposure on microglial cells and the possible effectiveness of a natural anti-inflammatory intervention with apigenin to mitigate these effects. From PND 0 to 28, 87 C57BL/6 J mice were exposed to one of six treatment conditions: 0 ppm Pb; 30 ppm Pb; 430 ppm Pb; 30 ppm Pb + 400 ppm apigenin; 430 ppm Pb + 400 ppm apigenin; or 400 ppm apigenin, via dams' drinking water. Following sacrifice, brain tissue was harvested and microglial cells were labeled via immunohistochemistry and counted within the dentate gyrus (DG) using unbiased stereology methods. It was hypothesized that developmental sub-chronic low-level lead exposure would increase microglial cell numbers within the DG and that apigenin treatment may mitigate these effects. A significant effect of treatment group was found and post-hoc analyses revealed that Pb-exposure generated an increased number of microglial cells as compared to controls. Interestingly, the 30 ppm Pb with apigenin treatment group did not generate microglial cell numbers different from the control group unexposed to Pb. These results suggested that developmental sub-chronic low-level lead exposure increased microglial cell activation within the DG and that, at low-levels of Pb exposure, apigenin treatment may mitigate these effects. These results provided the groundwork for studies that could identify an effective intervention to alleviate the effects of developmental chronic low-level lead exposure in child neurocognition.

发育性慢性低水平铅（Pb）暴露会破坏中枢神经系统功能并降低神经认知能力。小胶质细胞激活可能导致这些缺陷。本研究评估了发育亚慢性低水平铅暴露对小胶质细胞的影响，以及芹菜素天然抗炎干预减轻这些影响的可能效果。从PND 0到28,87只C57BL/6 J小鼠暴露于以下六种处理条件之一：0 ppm Pb；30 ppm铅;430 Pb ppm;30 ppm Pb + 400 ppm芹菜素；430 ppm Pb + 400 ppm芹菜素；或者400 ppm的芹菜素，通过大坝的饮用水。牺牲后，采集脑组织，通过免疫组织化学标记小胶质细胞，并使用无偏体视学方法在齿状回（DG）内计数。据推测，发育亚慢性低水平铅暴露会增加DG内的小胶质细胞数量，而芹菜素治疗可能减轻这些影响。发现治疗组有显著效果，事后分析显示，与对照组相比，暴露于铅会产生更多的小胶质细胞。有趣的是，30 ppm的铅与芹菜素处理组没有产生不同于未暴露于铅的对照组的小胶质细胞数量。这些结果表明，发育亚慢性低水平铅暴露增加了DG内的小胶质细胞活化，而在低水平铅暴露下，芹菜素治疗可能减轻这些影响。这些结果为研究提供了基础，可以确定有效的干预措施，以减轻发育性慢性低水平铅暴露对儿童神经认知的影响。

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引用次数: 0

Retraction notice to “Screening for novel central nervous system biomarkers in veterans with Gulf War Illness” [Neurotoxicology and Teratology 61 (2017) 36–46] 《海湾战争病退伍军人新型中枢神经系统生物标志物筛选》撤回通知[神经毒理学与畸形学61(2017)36-46]。

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2025-01-01 DOI: 10.1016/j.ntt.2024.107423

Mohamed B. Abou-Donia , Lisa A. Conboy , Efi Kokkotou , Eric Jacobson , Eman M. Elmasry , Passent Elkafrawy , Megan Neely , Cameron R. Dale Bass , Kimberly Sullivan

引用次数: 0

Corrigendum to “Stickler A, Hawkey AB, Gondal A, Natarajan S, Mead M, Levin ED. Embryonic exposures to cadmium and PAHs cause long-term and interacting neurobehavioral effects in zebrafish” [Neurotoxicol Teratol. 2024 Mar-Apr;102:107339. doi: 10.1016/j.ntt.2024.107339. Epub 2024 Mar 6] [j]张建军，张建军，李建军，等。多环芳烃和镉对斑马鱼的影响[j] .中国生物医学工程学报，2003,19(2):334 - 334。doi: 10.1016 / j.ntt.2024.107339。[j]。

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology

Pub Date : 2024-11-01 DOI: 10.1016/j.ntt.2024.107405

E.D. Levin

引用次数: 0