Clinicopathological analysis of 38 male patients diagnosed with breast cancer.

Breast disease Pub Date : 2024-01-01 DOI:10.3233/BD-230050

Seniha Irem Sahin, Serdar Balci, Gulnur Guler, Kadri Altundag

{"title":"Clinicopathological analysis of 38 male patients diagnosed with breast cancer.","authors":"Seniha Irem Sahin, Serdar Balci, Gulnur Guler, Kadri Altundag","doi":"10.3233/BD-230050","DOIUrl":null,"url":null,"abstract":"Background: Male breast cancer (MBC) accounts for one percent of all breast cancers. Due to the lack of awareness and routine screening programs, most patients present with systemic disease at the time of diagnosis with low overall survival.Objectives: This study aims to investigate the prognostic factors of male breast cancer and its correlation with established prognostic parameters and patient outcomes.Methods: Thirty-eight male breast cancer patients are identified from the MKA Breast Cancer Clinic database, and their corresponding clinical and pathological characteristics are obtained. Cut-off values of 1% and 10% are applied to further classify ER and PR results.Results: Older men are more likely to develop MBC than younger men and are more likely to have spread to axillary lymph nodes. Invasive ductal carcinoma is a more common histologic type in MBC. All the tested patients have ER and PR positivity. Distant metastasis developed in 17/38 (44.7%) patients. Bone metastasis is seen commonly in metastatic MBC.Conclusions: According to our cohort, MBC is seen in older males, presents in later stages, and shows hormone receptor positivity and a tendency to bone involvement. MBC is a heterogenous but distinct biological entity requiring a specific clinical and pathological approach.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10894578/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Breast disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/BD-230050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Male breast cancer (MBC) accounts for one percent of all breast cancers. Due to the lack of awareness and routine screening programs, most patients present with systemic disease at the time of diagnosis with low overall survival.

Objectives: This study aims to investigate the prognostic factors of male breast cancer and its correlation with established prognostic parameters and patient outcomes.

Methods: Thirty-eight male breast cancer patients are identified from the MKA Breast Cancer Clinic database, and their corresponding clinical and pathological characteristics are obtained. Cut-off values of 1% and 10% are applied to further classify ER and PR results.

Results: Older men are more likely to develop MBC than younger men and are more likely to have spread to axillary lymph nodes. Invasive ductal carcinoma is a more common histologic type in MBC. All the tested patients have ER and PR positivity. Distant metastasis developed in 17/38 (44.7%) patients. Bone metastasis is seen commonly in metastatic MBC.

Conclusions: According to our cohort, MBC is seen in older males, presents in later stages, and shows hormone receptor positivity and a tendency to bone involvement. MBC is a heterogenous but distinct biological entity requiring a specific clinical and pathological approach.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

对 38 名确诊为乳腺癌的男性患者进行临床病理分析。

背景：男性乳腺癌（MBC）占所有乳腺癌的百分之一。由于缺乏认识和常规筛查计划，大多数患者在确诊时已出现全身性疾病，总体生存率较低：本研究旨在调查男性乳腺癌的预后因素及其与既定预后参数和患者预后的相关性：方法：从 MKA 乳腺癌诊所数据库中找出 38 例男性乳腺癌患者，并获得其相应的临床和病理特征。结果：年龄较大的男性更容易罹患MMR：结果：老年男性比年轻男性更容易罹患乳腺导管癌，而且更容易扩散到腋窝淋巴结。浸润性导管癌是 MBC 更常见的组织学类型。所有受检患者的ER和PR均呈阳性。17/38（44.7%）例患者出现远处转移。骨转移常见于转移性MBC：根据我们的队列，MBC 多见于老年男性，出现于晚期，表现为激素受体阳性和骨受累倾向。MBC是一种异质但独特的生物实体，需要采用特定的临床和病理方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.