Immunotherapy for colorectal cancer: insight from inherited genetics.

IF 14.3 1区 医学 Q1 ONCOLOGY Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-02-14 DOI:10.1016/j.trecan.2024.01.008
Nijole Pollock Tjader, Amanda Ewart Toland
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Abstract

Immunotherapy shows efficacy for multiple cancer types and potential for expanded use. However, current immune checkpoint inhibitors (ICIs) are ineffective against microsatellite-stable colorectal cancer (CRC), which is more commonly diagnosed. Immunotherapy strategies for non-responsive CRC, including new targets and new combination therapies, are being tested to address this need. Importantly, a subset of inherited germline genetic variants associated with CRC risk are predicted to regulate genes with immune functions, including genes related to existing ICIs, as well as new potential targets in the major histocompatibility complex (MHC) region and immunoregulatory cytokines. We review discoveries in the inherited genetics of CRC related to the immune system and draw connections with ongoing developments and emerging immunotherapy targets.

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结直肠癌免疫疗法:遗传基因的启示。
免疫疗法对多种癌症类型都有疗效,并有扩大应用的潜力。然而,目前的免疫检查点抑制剂(ICIs)对微卫星稳定型结直肠癌(CRC)无效,而这种癌症的诊断率更高。为了满足这一需求,目前正在测试针对无反应性 CRC 的免疫疗法策略,包括新靶点和新的联合疗法。重要的是,与 CRC 风险相关的一部分遗传种系基因变异预计会调控具有免疫功能的基因,包括与现有 ICIs 相关的基因,以及主要组织相容性复合体(MHC)区域和免疫调节细胞因子中的新潜在靶点。我们回顾了与免疫系统相关的 CRC 遗传学发现,并将其与当前的发展和新兴的免疫疗法靶点联系起来。
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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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