Stochastic model of free radical yields in oriented DNA exposed to densely ionizing radiation at 77K.

J H Miller, W E Wilson, C E Swenberg, L S Myers, D E Charlton
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引用次数: 10

Abstract

Monte Carlo simulation techniques were used to calculate the probability that thymine radical anions (T.-), formed by the slowing-down of high-energy protons in oriented DNA, will undergo a secondary protonation reaction. By assuming a large asymmetry in the thermal conductivity of oriented DNA fibres we predict a significant enhancement of protonation of T.- when the proton flux is incident on the sample parallel to the orientation of the DNA. These results are in qualitative agreement with experimental data on the production of TH. radicals when oriented DNA is exposed to fast neutrons.

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取向DNA在77K强电离辐射下自由基产率的随机模型。
利用蒙特卡罗模拟技术计算了胸腺嘧啶自由基阴离子(t -)发生二次质子化反应的概率。胸腺嘧啶自由基阴离子是由定向DNA中的高能质子减速形成的。通过假设定向DNA纤维的热导率存在很大的不对称性,我们预测当质子通量平行于DNA取向入射到样品上时,t -质子化的显著增强。这些结果与TH生产的实验数据在定性上一致。当有取向的DNA暴露在快中子中时,就会产生自由基。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Repair of potentially lethal damage in unfed plateau phase cultures of Ehrlich ascites tumour cells. I. Suspension cultures. Effects of ionizing radiation on the metabolism and longitudinal growth of cartilaginous embryonic chick tibiae in vitro. Effect of non-volatile scavengers of hydroxyl radicals on thymine radical formation induced by gamma-rays and ultrasound. Stochastic model of free radical yields in oriented DNA exposed to densely ionizing radiation at 77K. Induction of sister chromatid exchanges (SCE) in G0 lymphocytes by plutonium-238 alpha-particles.
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