Annika Belzer, Jolanta J. Pach, Kailyn Valido, Jonathan S. Leventhal
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引用次数: 0
Abstract
Dermatologic adverse events resulting from oncologic therapy are common and negatively impact patients’ quality of life. Dermatologic adverse events include toxicity of the skin, oral mucosa, nails, and hair and are seen with cytotoxic chemotherapy, targeted therapy, immunotherapy, and radiation therapy, with distinct patterns of dermatologic adverse events by drug class. Here, we review the literature on the impact of dermatologic adverse events on quality of life. Studies on quality of life in patients with cancer have relied on scales such as the Dermatologic Life Quality Index and Skindex to demonstrate the association between dermatologic adverse events and declining quality of life. This relationship is likely due to a variety of factors, including physical discomfort, changes to body image, decreased self-esteem, and an effect on social interactions. Addressing such quality-of-life concerns for patients with cancer is critical, not only for patients’ well-being but also because decreased satisfaction with treatment can lead to discontinuation of treatment or dose reduction. Prophylactic treatment and early management of dermatologic adverse events by experienced dermatologists can alleviate the negative effects on quality of life and allow continuation of life-prolonging treatment.
肿瘤治疗引起的皮肤不良反应很常见,会对患者的生活质量产生负面影响。皮肤科不良事件包括皮肤、口腔粘膜、指甲和头发的毒性,常见于细胞毒性化疗、靶向治疗、免疫治疗和放射治疗,不同药物类别的皮肤科不良事件有不同的模式。在此,我们回顾了有关皮肤病不良事件对生活质量影响的文献。有关癌症患者生活质量的研究依赖于皮肤病生活质量指数(Dermatologic Life Quality Index)和Skindex等量表来证明皮肤病不良事件与生活质量下降之间的关系。这种关系可能是由多种因素造成的,包括身体不适、身体形象改变、自尊心下降以及对社会交往的影响。解决癌症患者的这些生活质量问题至关重要,这不仅关系到患者的福祉,还因为对治疗的满意度下降可能导致治疗中断或剂量减少。由经验丰富的皮肤科医生进行预防性治疗并及早处理皮肤科不良反应,可减轻对生活质量的负面影响,使延长生命的治疗得以继续。
期刊介绍:
The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.