Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Integrative Medicine Research Pub Date : 2024-02-06 DOI:10.1016/j.imr.2024.101023

Shanze Wang , Chao Yang , Weimei Zeng , Hongfang Tian , Shihao Du , Jiping Zhao

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Abstract

Background

Hashimoto's thyroiditis (HT) has a high incidence rate and unresolved clinical symptoms. Although Hand Yangming Meridian Penetrating Acupuncture has been used to treat thyroid diseases in China, there is no randomized controlled trial (RCT) on HT.

Methods

This exploratory RCT aims to preliminarily evaluate the efficacy, safety, and feasibility of Hand Yangming Meridian Penetrating Acupuncture in the treatment of HT. Included subjects were randomly assigned to the acupuncture group and the waiting treatment group at a ratio of 1:1. Subjects in the acupuncture group received 16 weeks of acupuncture treatment, followed by a 16-week follow-up observation phase. Subjects in the waiting group received thyroxine supplementation for 16 weeks, followed by 16 weeks of compensation treatment. Serum thyroid peroxidase antibody (TPOab) and thyroglobulin antibody (TGab) levels were the main indicators, and Thyroid-Related Patient-Reported Outcome short form (ThyPRO-39), MOS Item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS) scores were also recorded.

Results

In total, 58 subjects were included. After 16 weeks of treatment, there was no statistical difference in the changes in TPOab levels between the two groups, but the TGab level in the acupuncture group was significantly lower than in the waiting group (difference: −141.97 [95 % CI: −222.4 to −61.5], P = 0.011). Moreover, the total ThyPRO-39 and SF-36 scores were statistically different between the two groups (P_ThyPRO-39 < 0.001, P_SF-36 = 0.005). There was no statistical difference in HADS between the two groups.

Conclusions

Hand Yangming Meridian Penetrating Acupuncture may be safe and feasible for HT hypothyroidism to improve symptoms and reduce TGab levels.

Trial registration number

This trial was registered at Acupuncture-Moxibustion Clinical Trial Registry: AMCTR-IOR-19000308 (ChiCTR1900026830, https://www.chictr.org.cn/searchprojEN.html).

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针灸治疗桥本氏甲状腺炎：一项探索性随机对照试验

背景桥本氏甲状腺炎（HT）发病率高，临床症状难以缓解。本研究旨在初步评估手阳明经针刺治疗桥本氏甲状腺炎的疗效、安全性和可行性。58名受试者按1:1的比例随机分配到针灸组和等待治疗组。针灸组受试者接受16周的针灸治疗，然后进行16周的随访观察。等待治疗组的受试者先接受16周的甲状腺素补充治疗，然后再接受16周的补偿治疗。主要指标为血清甲状腺过氧化物酶抗体（TPOab）和甲状腺球蛋白抗体（TGab）水平，同时记录甲状腺相关患者报告结果简表（ThyPRO-39）、MOS项目健康调查简表（SF-36）和医院焦虑抑郁量表（HADS）评分。结果治疗16周后，两组的TPOab水平变化无统计学差异，但针刺组的TGab水平显著低于等待组（差异：-141.97 [95% CI：-222.4 至 -61.5]，P = 0.011）。此外，两组的 ThyPRO-39 和 SF-36 总分也存在统计学差异（PThyPRO-39 < 0.001，PSF-36 = 0.005）。试验注册号：AMCTR-IOR-19000308，ChiCTR1900026830（注册名称：手阳明经穴针刺治疗桥本氏甲状腺炎临床随机对照试验。注册网站：https://www.chictr.org.cn/searchprojEN.html)

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.