Integrative Medicine Research最新文献

Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients 服用灵芝后的症状改善和不良反应：癌症患者横断面调查

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-09-30 DOI: 10.1016/j.imr.2024.101089

Xiaotong Li , Lingyun Sun , Susan Chimonas , Susan Q. Li , Peng Feng , Yufei Yang , Jun J. Mao

Background

Reishi, a medicinal mushroom, is increasingly used for symptom control by cancer patients worldwide. However, data around patients' experiences with Reishi in oncology are lacking, limiting safe, effective clinical applications. We thus sought to evaluate patient reported benefits and harms of using Reishi.

Methods

We conducted a cross-sectional survey among Chinese cancer patients using Reishi products, probing for symptom improvements and/or adverse events (AEs) after taking Reishi. Multivariable logistic regression models assessed whether socio-demographic or clinical factors, as well as duration of Reishi use or combination with other TCM herbs, were associated with being a “responder” – reporting “quite a bit” or “very much” symptom improvement.

Results

Among 1374 participants, more than half of participants reported that nausea (55 %), fatigue (52 %), poor appetite (51 %), and depression (50 %) improved quite a bit or very much after taking Reishi. In multivariate analyses, age <65 years (adjusted odds ratios [AOR] = 1.76, p = 0.001), diagnosis ≥ 10 years (AOR = 1.78, p = 0.018), and duration of Reishi use ≥ 1 year (1–3 years: AOR = 1.53, p = 0.045; 3–5 years: AOR = 2.04, p = 0.001; >5 years: AOR = 2.07, p < 0.001) were significantly associated with higher responder rates for symptom improvement. However, 125 (9.1 %) also reported a range of AEs, including dry mouth (5 %), constipation (4 %), insomnia (3 %), pruritus (3 %) and vertigo (3 %).

Conclusion

While majority of cancer patients using Reishi reported symptom improvements, some reported adverse effects. This information can assist clinicians in advising cancer patients on safe and effective use of Reishi and help identify specific outcomes for assessment in future prospective clinical trials.

背景灵芝是一种药用蘑菇，越来越多地被世界各地的癌症患者用于控制症状。然而，有关患者使用灵芝治疗肿瘤的经验的数据却很缺乏，这限制了灵芝安全、有效的临床应用。因此，我们试图评估患者报告的使用灵芝的益处和害处。方法我们对使用灵芝产品的中国癌症患者进行了横断面调查，探究服用灵芝后症状改善情况和/或不良事件（AEs）。多变量逻辑回归模型评估了社会人口学或临床因素、服用灵芝的持续时间或与其他中草药合用是否与 "反应者"--症状改善 "相当多 "或 "非常多"--有关。结果在 1374 名参与者中，超过一半的人表示服用灵芝后恶心（55%）、疲劳（52%）、食欲不振（51%）和抑郁（50%）症状改善 "相当多 "或 "非常多"。在多变量分析中，年龄为 65 岁（调整后的几率比 [AOR] = 1.76，P = 0.001）、确诊时间≥ 10 年（AOR = 1.78，P = 0.018）、服用灵芝时间≥ 1 年（1-3 年，AOR = 1.53，P = 0.018）：AOR=1.53，p=0.045；3-5 年：AOR=2.04，p=0.001；>5 年：AOR=2.07，p=0.001）与较高的症状改善应答率明显相关。然而，也有 125 人（9.1%）报告了一系列不良反应，包括口干（5%）、便秘（4%）、失眠（3%）、瘙痒（3%）和眩晕（3%）。这些信息有助于临床医生指导癌症患者安全有效地使用灵芝，并有助于确定未来前瞻性临床试验的具体评估结果。

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引用次数: 0

Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial 草药提取物（林奈鹿、当归和黄芪）可改善慢性疲劳：随机、安慰剂对照、双盲试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-09-11 DOI: 10.1016/j.imr.2024.101085

SoYoung Ahn , Parivash Jamrasi , Byunggul Lim , Ji-won Seo , Xinxing Li , Shu Jiang , Yunho Sung , Seo Hyun Ahn , Chaeyoung Shin , Dongjin Noh , Bora Jin , Seonjoo Lee , Ki Won Lee , Jin Soo Kim , Young Tae Koo , Wook Song

Background

Chronic fatigue syndrome (CFS) reduces the health-related quality of life in the working-age population; however, studies have rarely investigated this group. A mixture of Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge (CAA) may be an effective anti-fatigue supplement. However, few clinical trials have explored the anti-fatigue effects of herbal medicines in human participants. Therefore, this study aimed to investigate the effects of the CAA herbal complex on muscle fatigue and endurance capacity in a randomized, placebo-controlled, double-blind trial.

Methods

In an 8-week trial, 80 patients with chronic fatigue symptoms were randomly assigned to the CAA (43.5 ± 1.2 years) or placebo group (41.8 ± 1.3 years). Fatigue and cardiorespiratory endurance were measured at baseline, interim, and post-intervention. Fatigue-related blood biomarkers were assessed before and at the end of the intervention.

Results

A significant improvement in overall fatigue scores was observed on the fatigue severity scale (p = 0.038), multidimensional fatigue inventory (p = 0.037), and 24-hour visual analog scale (p = 0.002) in the CAA group compared to those in the placebo group. Fatigue improvement was observed in the CAA group, as well as physiological variables, such as increased maximal exercise time to exhaustion (p = 0.003), distance until exhaustion (p = 0.003), and maximum oxygen consumption (p = 0.039).

Conclusion

CAA positively and significantly affected fatigue and cardiorespiratory endurance in patients with chronic fatigue, suggesting the potential use of herbal supplements for treating chronic fatigue.

Trial registration

Clinical Research Information Service (CRIS, https://cris.nih.go.kr/): KCT0005613.

背景慢性疲劳综合征（CFS）降低了工作年龄人群与健康相关的生活质量；然而，很少有研究对这一群体进行调查。林奈鹿、当归和黄芪的混合物（CAA）可能是一种有效的抗疲劳补充剂。然而，很少有临床试验探讨草药对人体的抗疲劳作用。因此，本研究旨在通过一项随机、安慰剂对照、双盲试验，研究 CAA 草本复方对肌肉疲劳和耐力能力的影响。方法在一项为期 8 周的试验中，80 名慢性疲劳症状患者被随机分配到 CAA 组（43.5 ± 1.2 岁）或安慰剂组（41.8 ± 1.3 岁）。分别在基线、中期和干预后测量疲劳和心肺耐力。结果与安慰剂组相比，CAA 组在疲劳严重程度量表（p = 0.038）、多维疲劳量表（p = 0.037）和 24 小时视觉模拟量表（p = 0.002）上的总体疲劳评分均有显著改善。结论CAA对慢性疲劳患者的疲劳和心肺耐力有积极而显著的影响，表明草药补充剂可能用于治疗慢性疲劳：KCT0005613。

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引用次数: 0

Acupuncture treatment is associated with a decreased risk of dementia in patients with rheumatoid arthritis in Taiwan: A propensity-score matched cohort study 针灸治疗与台湾类风湿关节炎患者痴呆症风险的降低有关：倾向分数匹配队列研究

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-09-08 DOI: 10.1016/j.imr.2024.101086

Hou-Hsun Liao , Ming-Cheng Huang , Yu-Chen Lee , Cheng-Li Lin , Mei-Yao Wu , Peter Karl Mayer , Hung-Rong Yen

Background

The purpose of this study was to understand whether acupuncture can decrease the risk of dementia in patients with rheumatoid arthritis (RA).

Methods

Using the registry from the National Health Insurance Research Database of Taiwan, we carried out a 1:1 propensity-score matched cohort study to analyze patients with RA diagnosed between 2000 and 2010. The patients who received acupuncture therapy were grouped as acupuncture users (n = 9,919), while the others were grouped as non-acupuncture users (n = 19,331). After propensity-score matching, the final sample included 9,218 matched participants in both groups, and these participants were followed up until the end of 2011. We used a Cox regression model to adjust for age, sex, comorbidiy, and conventional drugs and compared the hazard ratios (HRs) of developing dementia in the acupuncture and non-acupuncture groups.

Results

Acupuncture users tended to be more female-dominant and younger than non-acupuncture users. After propensity-score matching, both groups have comparable demographic characteristics. Acupuncture users had a lower risk of dementia than non-acupuncture users (adjusted HR: 0.55, 95% CI: 0.46–0.66). The cumulative incidence of dementia in the acupuncture group was significantly lower than that in the non-acupuncture group (log-rank test, p < 0.001). Patients who received the combinational treatment of conventional drugs and acupuncture had a significantly lower risk of developing dementia (adjusted HR: 0.64, 95% CI: 0.56–0.73) compared to those who only received conventional drugs.

Conclusion

Acupuncture therapy is associated with a reduced risk of dementia in patients with RA. Further clinical and mechanistic studies are needed.

背景本研究旨在了解针灸能否降低类风湿性关节炎（RA）患者的痴呆风险。方法我们利用台湾国民健康保险研究数据库的登记资料，对2000年至2010年间确诊的RA患者进行了1:1倾向得分匹配队列研究。接受针灸治疗的患者被归类为针灸使用者（n = 9919），其他患者被归类为非针灸使用者（n = 19331）。经过倾向分数匹配后，最终样本包括两组中的 9218 名匹配参与者，并对这些参与者进行随访至 2011 年底。我们使用 Cox 回归模型对年龄、性别、合并症和常规药物进行了调整，并比较了针灸组和非针灸组患痴呆症的危险比（HRs）。经过倾向分数匹配后，两组的人口统计学特征相当。针灸使用者患痴呆症的风险低于非针灸使用者（调整HR：0.55，95% CI：0.46-0.66）。针灸组痴呆的累积发病率明显低于非针灸组（对数秩检验，P < 0.001）。与仅接受常规药物治疗的患者相比，接受常规药物和针灸联合治疗的患者患痴呆症的风险明显降低（调整HR：0.64，95% CI：0.56-0.73）。结论针灸治疗与降低RA患者痴呆风险有关，还需要进一步的临床和机理研究。

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引用次数: 0

Long-term follow-up of the treatment for severe COVID-19 with qigong exercise and acupressure: A randomized controlled trial 气功锻炼和穴位按摩治疗重度 COVID-19 的长期随访：随机对照试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-09-05 DOI: 10.1016/j.imr.2024.101084

Shuting Liu , Ranran Zhu , Chongjie Yao , Chao Zhan , Jinxiang Wang , Min Fang , Lei Fang

Background

Most clinical trials have reported significant short-term effects of traditional medicine therapies on COVID-19 patients. However, there is no clinical trial to determine the long-term effects of traditional medicine therapies on severe COVID-19 patients.

Methods

A total of 128 patients with severe COVID-19, who were recruited in our previous clinical trial following hospital discharge, were monitored at months 14 and 28. This trial aims to evaluate the long-term effect of an early Qigong exercise and acupressure rehabilitation program on patients with severe COVID-19.The intervention group received qigong exercise and acupressure therapy, plus standard therapies. The control group received standard therapies.The study was a single-center, parallel, randomized, prospective follow-up study. The outcomes of the study included changes in the modified Borg dyspnea scale (MBS), the modified Medical Research Council dyspnea scale (mMRC), the patient health questionnaire-9 scale (PHQ-9), the activity of daily living (ADL), the remaining clinical symptoms and any intervention related adverse events.

Results

The intervention group showed a statistically significant improvement in the mMRC scores (−0.4, 95 % CI (−0.6, 0.2), P < 0.001) and the MBS scores (−0.6, 95 % CI (−0.9, −0.3), P < 0.001) after 14 months of discharge compared with the control group. At 28 months of discharge, the intervention group, compared with the control group alone, significantly increased their MBS scores (−0.4, 95 % CI (−0.7, −0.1), P = 0.024) and a significantly decreased positive rate of dyspnea symptoms after 14 months of discharge (P < 0.05). However, ADL and PHQ-9 scores showed no significant difference between the two groups during the follow-up (P > 0.05).

Conclusions

QARP had long-term sustained efficacy for dyspnea, chest tightness, and cough in patients with COVID-19, especially in young and middle-aged patients, and the effect was significant at the 14th month of follow-up.

Trial registration

This trial was registered at the China Clinical Trial Registry (ChiCTR2100044572).

背景大多数临床试验报告了传统药物疗法对COVID-19患者的短期疗效。方法我们在之前的临床试验中招募了 128 名出院后的重度 COVID-19 患者，对他们进行了第 14 个月和第 28 个月的监测。本试验旨在评估早期气功锻炼和穴位按摩康复计划对重度COVID-19患者的长期影响。该研究是一项单中心、平行、随机、前瞻性随访研究。研究结果包括改良博格呼吸困难量表（MBS）、改良医学研究委员会呼吸困难量表（mMRC）、患者健康问卷-9量表（PHQ-9）、日常生活活动能力（ADL）、其余临床症状以及任何与干预相关的不良事件的变化。结果与对照组相比，干预组在出院 14 个月后的 mMRC 评分（-0.4，95 % CI (-0.6, 0.2)，P < 0.001）和 MBS 评分（-0.6，95 % CI (-0.9, -0.3)，P < 0.001）均有统计学意义上的显著改善。出院 28 个月时，干预组与对照组相比，出院 14 个月后，干预组的 MBS 评分显著增加（-0.4，95 % CI (-0.7，-0.1)，P = 0.024），呼吸困难症状阳性率显著下降（P < 0.05）。结论QARP对COVID-19患者，尤其是中青年患者的呼吸困难、胸闷和咳嗽有长期持续疗效，在随访第14个月时疗效显著。

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引用次数: 0

Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats 高丽红参水提取物对左甲状腺素诱导的甲状腺功能亢进和丙基硫氧嘧啶诱导的甲状腺功能减退大鼠的保护作用

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-08-17 DOI: 10.1016/j.imr.2024.101071

Lei Huang , Won Young Jang , Ji Hye Yoon , Zhenyan Piao , Jinghan Su , Dong Seon Kim , Ki Woong Kwon , Ji Won Kim , Sang Hee Park , Sunggyu Kim , Jong-Hoon Kim , Jae Youl Cho

Background

Korean red ginseng extract (KRGE) (Family: Araliaceae) is one of the most widely used traditional herbs in Asia. Multiple studies have shown that KRGE has anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects.

Methods

Sprague-Dawley rats were divided into five groups for PTU-induced hypothyroidism and six groups for LT4-induced hyperthyroidism. At the experiment's conclusion, rats were sacrificed, and blood, thyroid gland, and liver samples were collected. Body weight was recorded weekly, and serum hormone levels were assessed using enzyme-linked immunoassay. Thyroid gland and liver tissues were stained with hematoxylin and eosin. KRGE was prepared in 0.5% CMC and stored at 4 °C before administration.

Results

In the LT4-induced hyperthyroidism model, KRGE prevented decreases in body weight, thyroid gland weight, liver weight, serum glucose, and thyroid hormone levels compared to the PTU group. It also reduced increases in T3, T4, and serum aspartate aminotransferase levels after LT4 treatment. Additionally, KRGE improved thyroid gland and liver histopathology, effects not observed in the PTU-induced hypothyroidism model.

Conclusion

All things considered, our research points to KRGE's potential protective role in rat hyperthyroidism caused by LT4 by lowering thyroid hormone production.

背景韩国红参提取物（KRGE）（五加科）是亚洲使用最广泛的传统草药之一。方法将Sprague-Dawley大鼠分为5组进行PTU诱导的甲状腺功能减退症实验，6组进行LT4诱导的甲状腺功能亢进症实验。实验结束后，处死大鼠并采集血液、甲状腺和肝脏样本。每周记录体重，并使用酶联免疫法评估血清激素水平。甲状腺和肝组织用苏木精和伊红染色。结果在 LT4 诱导的甲亢模型中，与 PTU 组相比，KRGE 可防止体重、甲状腺重量、肝脏重量、血清葡萄糖和甲状腺激素水平的下降。它还能降低 LT4 治疗后 T3、T4 和血清天冬氨酸氨基转移酶水平的升高。此外，KRGE 还能改善甲状腺和肝脏组织病理学，这在 PTU 诱导的甲状腺功能减退症模型中没有观察到。

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引用次数: 0

An evidence map on traditional medicine across health outcomes 传统医学在健康成果方面的证据图谱

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-07-25 DOI: 10.1016/j.imr.2024.101070

Lin Ang , Eunhye Song , Miek C Jong , Terje Alræk , Barbara Wider , Tae-Young Choi , Ji Hee Jun , Boram Lee , Yujin Choi , Hye Won Lee , Changsop Yang , Mi Hong Yim , Hitoshi Yamashita , Zhaochen Ji , Haiyin Hu , Junhua Zhang , Jianping Liu , Yaolong Chen , Yishan Qin , Liming Lu , Myeong Soo Lee

Background

Traditional medicine (TM) plays a significant role in healthcare either as part of the primary healthcare system or as an adjunct to conventional medicine. This study aimed to map systematic reviews (SRs) of TM modalities across health conditions and identify gaps in the research literature to facilitate priority setting in future TM research.

Methods

We searched 17 databases from January 2018 to December 2022. Reviewers in pairs independently performed the database search, screened each record for inclusion, extracted data, and performed quality assessments using the AMSTAR 2 - A Measurement Tool to Assess systematic Reviews. To be included in this evidence map, the studies had to be SRs of clinical studies that evaluated the effectiveness of a TM modalities. The included SRs were analyzed according to TM modality, ICD-11 disease classification, and health outcomes, and visualized using graphical plots.

Results

We retrieved 241,509 records. After excluding duplicate records, 181,616 titles and abstracts were screened and 20,856 records were selected for full-text assessment, of which 18,137 records were further excluded. The final 2719 included SRs were primarily in adults (2591) with only 128 SRs in the pediatric population. The most commonly evaluated health conditions were diseases of the digestive system, circulatory system, and genitourinary system, with herbal medicine (n = 1867) and acupuncture (n = 471) being the most investigated TM modalities in treating these illnesses. Based on AMSTAR 2 criteria, the methodology quality of the included SRs is considerably low.

Conclusion

This evidence map provides a comprehensive overview of the extent and nature of the available research onTM modalities across health conditions. It provides an initial step towards characterizing the global evidence base and outlining gaps in the existing evidence. We regard this study as laying the basis for future research of TM modalities.

Registration

The protocol of this map is registered in PROSPERO (CRD42023416355).

背景传统医学（TM）作为初级医疗保健系统的一部分或传统医学的辅助手段，在医疗保健领域发挥着重要作用。本研究旨在绘制不同健康状况下传统医学模式的系统综述（SR）图，并找出研究文献中的空白点，以便于确定未来传统医学研究的优先次序。方法我们检索了2018年1月至2022年12月期间的17个数据库。审稿人两人一组独立进行数据库检索、筛选每条记录以纳入、提取数据，并使用 AMSTAR 2 - 系统性综述评估测量工具进行质量评估。纳入本证据图谱的研究必须是评估 TM 方式有效性的临床研究 SR。我们根据 TM 方式、ICD-11 疾病分类和健康结果对纳入的 SR 进行了分析，并使用图表对其进行可视化。在排除重复记录后，我们筛选了 181616 条标题和摘要，并选择了 20856 条记录进行全文评估，进一步排除了其中的 18137 条记录。最终收录的 2719 条 SR 主要针对成年人（2591 条），只有 128 条 SR 针对儿童群体。最常评估的健康状况是消化系统、循环系统和泌尿生殖系统疾病，其中草药（n = 1867）和针灸（n = 471）是治疗这些疾病的最常用的中医疗法。根据 AMSTAR 2 标准，纳入的 SR 的方法学质量相当低。它为确定全球证据基础的特征和概述现有证据的差距迈出了第一步。我们认为本研究为未来的 TM 模式研究奠定了基础。注册本地图的协议已在 PROSPERO 注册（CRD42023416355）。

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引用次数: 0

Effectiveness and safety of Liriope Tuber (Liriopis seu Ophiopogonis Tuber, Maidong) included traditional herbal medicine for patients with paroxysmal atrial fibrillation: A systematic review, meta-analysis, and network analysis 包括麦冬在内的传统草药对阵发性心房颤动患者的有效性和安全性：系统综述、荟萃分析和网络分析

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-07-23 DOI: 10.1016/j.imr.2024.101069

Hanbit Jin , Sukjong Kang , Dasol Park , Yeun-Ja Mun , Jungtae Leem

Background

Conventional medicine (CM) for paroxysmal atrial fibrillation (PAF) have limitations and side effects. Integrative approaches, including traditional herbal medicines like Liriope Tuber, are being explored for potential benefits, although evidence remains limited.

Methods

In April 2023, a literature search was conducted across nine databases, focusing on randomized controlled trials assessing the effects of Liriope Tuber in traditional herbal medicine (LTHM) on PAF. The risk of bias was evaluated using Version 2 of the Cochrane risk-of-bias tool for randomized trials. A random-effects model was employed for the meta-analysis.

Results

A total of 43 studies with 3,743 participants were included. The meta-analysis indicated that adding LTHM to CM reduced PAF frequency (SMD = -0.99, 95 % CI = -1.40 to -0.57, I² = 88 %, N = 16, n = 1266), left atrium diameter (LAD) (MD = -2.39 mm, 95 % CI = -3.09 to -1.68), P-wave dispersion (Pd) (MD = -6.41 ms, 95 % CI = -8.44 to -4.37), high sensitive C-Reactive Protein (hs-CRP) (MD = -1.10 mg/l, 95 % CI = -1.73 to -0.47), and improved left ventricular ejection fraction (LVEF) (MD = 4.71 %, 95 % CI = 3.17 to 6.25). Thirty-four studies raised concerns about bias, with eight showing high risk. Certainty of evidence was rated as "low" for PAF frequency, LAD, Pd, hs-CRP, and LVEF.

Conclusion

LTHM combined with CM may reduce PAF frequency. However, due to the complexity of interventions, with Liriope Tuber being only one component of the regimen, high risk of bias, substantial heterogeneity, and indirectness, interpretations should be cautious.

Study registration

PROSPERO (ID: CRD42023477926).

背景治疗阵发性心房颤动（PAF）的传统药物（CM）具有局限性和副作用。2023 年 4 月，研究人员在 9 个数据库中进行了文献检索，重点是评估传统草药（LTHM）中 Liriope Tuber 对 PAF 影响的随机对照试验。采用科克伦随机试验偏倚风险工具第 2 版对偏倚风险进行了评估。结果共纳入 43 项研究，3743 人参与。荟萃分析表明，在 CM 中加入 LTHM 可降低 PAF 频率（SMD = -0.99，95 % CI = -1.40 至 -0.57，I² = 88 %，N = 16，n = 1266）、左心房直径（LAD）（MD = -2.39 mm，95 % CI = -3.09 至 -1.68）、P 波频散（Pd）（MD = -6.41 ms，95 % CI = -8.44 to -4.37）、高敏感 C 反应蛋白（hs-CRP）（MD = -1.10 mg/l，95 % CI = -1.73 to -0.47）和左室射血分数（LVEF）改善（MD = 4.71 %，95 % CI = 3.17 to 6.25）。34项研究提出了偏倚问题，其中8项研究显示存在高风险。PAF频率、LAD、Pd、hs-CRP和LVEF的证据确定性被评为 "低"。然而，由于干预措施的复杂性（Liriope Tuber 只是治疗方案中的一个组成部分）、高偏倚风险、大量异质性和间接性，解释时应谨慎。

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引用次数: 0

How can meta-research be used to evaluate and improve the quality of research in the field of traditional, complementary, and integrative medicine? 如何利用元研究来评估和提高传统医学、补充医学和中西医结合医学领域的研究质量？

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-07-08 DOI: 10.1016/j.imr.2024.101068

Jeremy Y. Ng , Myeong Soo Lee , Jian-ping Liu , Amie Steel , L. Susan Wieland , Claudia M. Witt , David Moher , Holger Cramer

The field of traditional, complementary, and integrative medicine (TCIM) has garnered increasing attention due to its holistic approach to health and well-being. While the quantity of published research about TCIM has increased exponentially, critics have argued that the field faces challenges related to methodological rigour, reproducibility, and overall quality. This article proposes meta-research as one approach to evaluating and improving the quality of TCIM research. Meta-research, also known as research about research, can be defined as “the study of research itself: its methods, reporting, reproducibility, evaluation, and incentives”. By systematically evaluating methodological rigour, identifying biases, and promoting transparency, meta-research can enhance the reliability and credibility of TCIM research. Specific topics of interest that are discussed in this article include the following: 1) study design and research methodology, 2) reporting of research, 3) research ethics, integrity, and misconduct, 4) replicability and reproducibility, 5) peer review and journal editorial practices, 6) research funding: grants and awards, and 7) hiring, promotion, and tenure. For each topic, we provide case examples to illustrate meta-research applications in TCIM. We argue that meta-research initiatives can contribute to maintaining public trust, safeguarding research integrity, and advancing evidence based TCIM practice, while challenges include navigating methodological complexities, biases, and disparities in funding and academic recognition. Future directions involve tailored research methodologies, interdisciplinary collaboration, policy implications, and capacity building in meta-research.

传统医学、补充医学和综合医学（TCIM）因其对健康和福祉的整体性研究方法而受到越来越多的关注。虽然发表的有关传统、补充和整合医学的研究数量呈指数增长，但批评者认为该领域在方法的严谨性、可重复性和整体质量方面面临挑战。本文提出元研究作为评估和提高 TCIM 研究质量的一种方法。元研究，也被称为关于研究的研究，可以定义为 "对研究本身的研究：研究方法、报告、再现性、评估和激励机制"。通过系统地评估研究方法的严谨性、识别偏差和提高透明度，元研究可以提高 TCIM 研究的可靠性和可信度。本文讨论的具体主题包括以下几个方面：1) 研究设计和研究方法；2) 研究报告；3) 研究道德、诚信和不当行为；4) 可复制性和可再现性；5) 同行评审和期刊编辑实践；6) 研究经费：拨款和奖励；7) 聘用、晋升和终身职位。对于每个主题，我们都提供了案例来说明元研究在 TCIM 中的应用。我们认为，元研究计划有助于维护公众信任、保障研究诚信和推进循证 TCIM 实践，而面临的挑战包括如何应对方法论的复杂性、偏见以及资金和学术认可方面的差异。未来的方向涉及量身定制的研究方法、跨学科合作、政策影响以及元研究的能力建设。

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引用次数: 0

A practical guide to implementing artificial intelligence in traditional East Asian medicine research 在传统东亚医学研究中应用人工智能的实用指南

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-07-07 DOI: 10.1016/j.imr.2024.101067

Hyojin Bae , Sa-Yoon Park , Chang-Eop Kim

In this paper, we present a comprehensive guide for implementing artificial intelligence (AI) techniques in traditional East Asian medicine (TEAM) research. We cover essential aspects of the AI model development pipeline, including research objective establishment, data collection and preprocessing, model selection, evaluation, and interpretation. The unique considerations in applying AI to TEAM datasets, such as data scarcity, imbalance, and model interpretability, are discussed. We provide practical tips and recommendations based on best practices and our own experience. The potential of large language models in TEAM research is also highlighted. Finally, we discuss the challenges and future directions of AI application in TEAM, emphasizing the need for standardized data collection and sharing platforms.

本文介绍了在传统东亚医学（TEAM）研究中实施人工智能（AI）技术的综合指南。我们介绍了人工智能模型开发流程的基本方面，包括研究目标的确立、数据收集和预处理、模型选择、评估和解释。讨论了将人工智能应用于 TEAM 数据集的独特考虑因素，如数据稀缺性、不平衡性和模型可解释性。我们将根据最佳实践和自身经验提供实用的提示和建议。我们还强调了大型语言模型在 TEAM 研究中的潜力。最后，我们讨论了在 TEAM 中应用人工智能的挑战和未来方向，强调了标准化数据收集和共享平台的必要性。

引用次数: 0

Herbal medicine Oryeongsan (Wulingsan): Cardio-renal effects via modulation of renin-angiotensin system and atrial natriuretic peptide system 草药 Oryeongsan（五灵山）：通过调节肾素-血管紧张素系统和心房利钠肽系统实现心肾功效

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-06-22 DOI: 10.1016/j.imr.2024.101066

Ho Sub Lee , Hye Yoom Kim , You Mee Ahn , Kyung Woo Cho

Background

Oryeongsan (Wulingsan, Goreisan) has long been used for the treatment of impaired body fluid metabolism. However, the action mechanisms have not been clearly defined. Recently, effects of Oryeongsan on the body fluid and Na⁺ metabolism and the action mechanisms have been shown more clearly. The present review focuses on the recent findings on the effects of Oryeongsan in the cardio-renal system in relation with body fluid metabolism and action mechanisms leading to a decrease in blood pressure in animal models of hypertension.

Methods

The new and recent findings were searched by using searching systems including PubMed-NCBI and Google-Scholar.

Results

Oryeongsan induced an increase in glomerular filtration rate, and natriuresis and diuresis with a decreased osmolality and resulted in a contraction of the body fluid and Na⁺ balance. These findings were associated with a suppression of abundance of Na⁺-H⁺-exchanger isoform 3 expression and V₂ receptor/aquaporin2 water channel signaling pathway in the kidney. Further, treatment with Oryeongsan accentuated atrial natriuretic peptide secretion in the atria from spontaneously hypertensive rats in which the secretion was suppressed. In addition, Oryeongsan ameliorated impaired vasodilation in spontaneously hypertensive rats.

Conclusion

The effects of Oryeongsan in the kidney, atria, and vessel were accompanied by a suppression of AT₁ receptor and concurrent accentuation of abundance of AT₂/Mas receptors expression and modulation of the natriuretic peptide system in these organs from hypertensive rats. The review shows multiple sites of action of Oryeongsan and mechanisms involved in the regulation of volume and pressure homeostasis in the body.

背景御灵丹（五灵丹，Goreisan）长期以来一直被用于治疗体液代谢障碍。然而，其作用机制尚未明确。最近，奥利昂散对体液和 Na+ 代谢的影响及其作用机制得到了更明确的显示。本综述重点介绍了最近关于欧龙山对心肾系统的影响与体液代谢的关系以及导致高血压动物模型血压下降的作用机制的研究结果。方法使用 PubMed-NCBI 和 Google-Scholar 等搜索系统搜索最新研究结果。这些发现与抑制肾脏中 Na+-H+- exchanger isoform 3 的大量表达和 V2 受体/quaporin2 水通道信号通路有关。此外，用 Oryeongsan 治疗自发性高血压大鼠心房时，其心房钠尿肽的分泌受到抑制，而用 Oryeongsan 治疗自发性高血压大鼠心房时，其心房钠尿肽的分泌则会增加。结论欧龙山对高血压大鼠肾脏、心房和血管的作用是抑制 AT1 受体，同时提高 AT2/Mas 受体的表达量，并调节这些器官的利钠肽系统。综述显示了御灵散的多个作用位点以及参与调节体内容量和压力平衡的机制。

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引用次数: 0