Integrative Medicine Research最新文献

英文中文

Comparative effectiveness of Chinese herbal medicine versus liraglutide for weight loss in adults with obesity: A 12-month real-world target trial emulation study 中草药与利拉鲁肽对成人肥胖患者减肥的比较效果：一项为期12个月的真实世界目标试验模拟研究

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2026-01-06 DOI: 10.1016/j.imr.2026.101291

Yu-Ning Liao , Tsung-Hsien Yang , Yi-Chin Lu , Liang-Wei Tseng , Ching-Wei Yang , Yu-Tung Huang , Hsing-Yu Chen

Background

Chinese herbal medicine (CHM) is commonly used for weight control in Taiwan. This study aimed to compare the effectiveness and mechanisms of a fixed combination of CHM with liraglutide using a target trial emulation real-world study.

Methods

From January 1, 2013, to December 31, 2018, subjects from the multi-institutional Chang Gung Research Database (CGRD) with a BMI ≥ 25 kg/m² received a fixed combination of Ma-Xing-Gan-Shi-Tang and Coptis chinensis Franch, namely Ma-Xing-Gan-Shi-Tang and Coptis chinensis Franch LOwering Weight formula (MCLOW), were compared with those using liraglutide for weight control for a 12-month follow-up course with overlap weighting for baseline inequality.

Results

Among 376 subjects, 135 (35.9%) used MCLOW, who lost more weight from baseline (-6.07 [95% CI:6.90 to -5.24] vs. -1.66 [95% CI:2.22 to -1.1] kg; p-value < 0.001), and had a higher proportion achieved weight reductions of ≥ 5% and ≥ 10% (68.15% vs. 23.65%, p < 0.001 and 32.59% vs. 7.05%, p-value < 0.001, respectively). The results were consistent with overlap and inverse probability of treatment weighting models. By using network pharmacology, use of MCLOW was associated with lipid metabolism and immune-related pathways, while liraglutide was linked to insulin-secretion pathways.

Conclusion

The CHM formula MCLOW appears to have promising effects on weight loss, with mechanisms differing from but complementary to those of Western medicines.

在台湾，中草药（CHM）常被用来控制体重。本研究旨在通过目标试验模拟现实世界研究，比较中药与利拉鲁肽固定联合的有效性和机制。方法2013年1月1日至2018年12月31日，来自多机构长庚研究数据库（CGRD）的BMI≥25 kg/m²的受试者，接受了固定的马行甘湿汤和黄连的组合，即马行甘湿汤和黄连的降体重公式（MCLOW），并与使用利拉鲁tide进行体重控制的患者进行了12个月的随访，基线不平等进行重叠加权。结果在376名受试者中，135名（35.9%）使用MCLOW，比基线体重减轻更多（-6.07 [95% CI:6.90至-5.24]对-1.66 [95% CI:2.22至-1.1]kg， p值<； 0.001），体重减轻≥5%和≥10%的比例更高（68.15%对23.65%,p <； 0.001和32.59%对7.05%，p值<； 0.001）。结果与处理加权模型的重叠和逆概率一致。通过网络药理学，MCLOW的使用与脂质代谢和免疫相关途径有关，而利拉鲁肽与胰岛素分泌途径有关。结论中药复方MCLOW具有良好的减肥效果，其作用机制与西药不同，但与西药互补。

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引用次数: 0

Efficacy of personalized acupuncture combined with accelerated deep transcranial magnetic stimulation in mild cognitive impairment: A randomized controlled trial 个体化针刺联合加速深经颅磁刺激治疗轻度认知障碍的疗效：一项随机对照试验

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2026-01-05 DOI: 10.1016/j.imr.2026.101289

Jing Xia , Xinhe Wu , Zitao Wang , Lei Zhang , Ping Xu , Peipei Zhao , Peilong Liu , Yanan Shao , Xipeng Zhang , Yiran Lu , Xiaojie Qin , Xinjian Song

Background

This study evaluated the efficacy of combining personalized acupuncture with accelerated deep transcranial magnetic stimulation (adTMS) for mild cognitive impairment (MCI).

Methods

In this randomized, double-blind, controlled trial, 120 MCI patients were assigned to a Combined group (personalized acupuncture + active adTMS), a Single Stimulation group (active adTMS + sham acupuncture), or a Placebo group (sham TMS + sham acupuncture). The primary outcome was the change in Montreal Cognitive Assessment (MoCA) score at 12 weeks. Secondary outcomes included P300 latency, magnetic resonance spectroscopy (MRS) NAA/Cr ratio, serum brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), interleukin-6 (IL-6), and the Modified Barthel Index (MBI).

Results

The Combined group showed a significantly greater improvement in MoCA scores (3.2 ± 1.3 points) compared to the Single Stimulation (1.9 ± 1.2 points; mean difference 1.3, 95 % CI 0.4 to 2.2) and Placebo groups (1.1 ± 1.0 points; mean difference 2.1, 95 % CI 1.2 to 3.0). The Combined group also demonstrated greater reductions in P300 latency and increases in NAA/Cr ratio and serum BDNF levels than the other groups.

Conclusion

The combination of personalized acupuncture and adTMS significantly improves cognitive function in MCI patients, supported by positive changes in electrophysiological and metabolic markers. This integrative approach represents a promising non-pharmacological strategy for MCI.

Trial registration: International Traditional Medicine Clinical Trials Registry (ITMCTR2025000652).

本研究评价个体化针刺联合加速深经颅磁刺激（adTMS）治疗轻度认知障碍（MCI）的疗效。方法随机、双盲、对照试验将120例MCI患者分为联合组（个性化针灸+主动adTMS）、单刺激组（主动adTMS +假针灸）和安慰剂组（假TMS +假针灸）。主要结果是12周时蒙特利尔认知评估（MoCA）评分的变化。次要指标包括P300潜伏期、磁共振波谱（MRS） NAA/Cr比值、血清脑源性神经营养因子（BDNF）、c反应蛋白（CRP）、白细胞介素-6 （IL-6）和改良Barthel指数（MBI）。结果联合组MoCA评分（3.2±1.3分）较单纯刺激组（1.9±1.2分，平均差异1.3分，95% CI 0.4 ~ 2.2）和安慰剂组（1.1±1.0分，平均差异2.1分，95% CI 1.2 ~ 3.0）有显著性改善。与其他组相比，联合治疗组也表现出P300潜伏期的更大降低，NAA/Cr比率和血清BDNF水平的增加。结论个体化针刺与adTMS联合治疗可显著改善MCI患者的认知功能，并伴有电生理和代谢指标的积极变化。这种综合方法代表了一种有希望的MCI非药物治疗策略。试验注册：国际传统医学临床试验注册中心（ITMCTR2025000652）。

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引用次数: 0

Integrating east Asian traditional medicine into National Dementia care: A comparative policy analysis of China, Japan, and South Korea 将东亚传统医学纳入国家痴呆症护理：中国、日本和韩国的比较政策分析

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2026-01-05 DOI: 10.1016/j.imr.2026.101290

Chan-Young Kwon , Chen Shen , Tetsuhiro Yoshino , Jihyeon Lee , Yujin Han

引用次数: 0

Misleading readers without lies: understanding spin and its relevance to acupuncture research 没有谎言的误导读者：理解旋转及其与针灸研究的相关性

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-12-31 DOI: 10.1016/j.imr.2025.101288

Inhu Bae , Yu-jin Ji , Hyangsook Lee

This article provides an overview of spin in general and the current state of spin research in acupuncture studies. We introduce the definition and historical background of spin and provide an overview of its types with illustrative examples. Spin, reporting strategies that emphasise benefits or distract from non-significant results, may still be unfamiliar to many researchers, despite its critical impact on physicians and decision-makers by distorting interpretation and misrepresenting findings. We discuss not only the current state of spin research in the acupuncture field, but also specific types of spin commonly observed in acupuncture publications. Finally, we issue a call to action for researchers, journal editors, reviewers, and decision-makers to prevent spin in research articles. Reducing spin requires multifaceted efforts, including strict adherence to reporting guidelines, rigorous editorial and peer review processes, and increased awareness and training among researchers. By adopting a multidimensional approach, acupuncture researchers can become more alert to misleading reporting practices and ultimately improve the overall quality of reporting.

本文综述了自旋在针刺研究中的研究现状。介绍了自旋的定义和历史背景，并通过实例对其类型进行了概述。Spin，即强调益处或分散对非显著结果的报道策略，可能对许多研究人员来说仍然是陌生的，尽管它通过扭曲解释和歪曲发现对医生和决策者产生了关键影响。我们不仅讨论了自旋在针灸领域的研究现状，还讨论了在针灸出版物中常见的自旋的具体类型。最后，我们向研究人员、期刊编辑、审稿人和决策者发出行动呼吁，以防止研究文章中的虚假报道。减少虚假报道需要多方面的努力，包括严格遵守报告准则、严格的编辑和同行评议程序，以及提高对研究人员的认识和培训。通过采用多维度的方法，针灸研究人员可以更加警惕误导性的报告实践，最终提高报告的整体质量。

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引用次数: 0

Demographic and behavioral correlation of red ginseng consumption in Korea 韩国红参消费的人口统计学和行为学相关性

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-12-31 DOI: 10.1016/j.imr.2025.101287

DeYu Tian , KeunOh Choi , Yong-ung Kim , YoungJoo Lee

Background

As one of the most famous ginseng products, red ginseng has had a huge market and influence in the healthcare market.

Methods

We recruited 3000 adults of all ages and social classes from different parts of Korea to conduct a questionnaire survey for statistical analysis and analyzed the results of the questionnaire survey through logistic regression. The questionnaire included information on the experience of red ginseng intake in a year, whether or not they consumed red ginseng on a regular basis, as well as information on income, age, and family composition that may affect red ginseng intake.

Results

The results showed that men and high-income groups had a higher acceptance of red ginseng; children number of the family has a non-linear effect on the probability of trying red ginseng; and groups who take other dietary supplements were also more willing to take red ginseng.

Conclusions

These results provide valuable information for understanding the demographic and behavioral characteristics of red ginseng consumers and highlight the need to consider integrated health strategies, as well as providing data to inform the development of red ginseng products and the direction of campaigns to promote red ginseng applications.

红参作为最著名的人参产品之一，在保健市场上有着巨大的市场和影响。方法从韩国不同地区招募3000名不同年龄、社会阶层的成年人进行问卷调查，并对问卷调查结果进行logistic回归分析。调查问卷包括一年内摄入红参的经历，是否定期食用红参，以及收入、年龄和家庭构成等可能影响红参摄入量的信息。结果男性和高收入人群对红参的接受程度较高；家庭子女数对尝试红参的概率呈非线性影响；服用其他膳食补充剂的人也更愿意服用红参。结论本研究结果为了解红参消费者的人口学特征和行为特征提供了有价值的信息，强调了综合健康策略的必要性，并为红参产品的开发和推广红参应用的运动方向提供了数据。

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引用次数: 0

Concurrent Chinese and Western medication use and risk of acute exacerbations in chronic obstructive pulmonary disease: A national cohort study 慢性阻塞性肺疾病患者同时使用中西药和急性加重风险：一项国家队列研究

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-12-31 DOI: 10.1016/j.imr.2025.101286

Ming-Chia Lee , Chih-Yuan Wu , Shih-Ming Chen , Ya-Hui Chang , Tzu-Rong Peng , Jin-Hua Chen , Shoko Satake , Jen-Ai Lee , Chih-Hsin Lee , Jann-Yuan Wang

Background

This study examined whether concurrent use of Chinese medications (CMs) and Western medications (WMs) was associated with a reduced risk of acute exacerbation (AE) in patients with chronic obstructive pulmonary disease (COPD).

Methods

Using Taiwan’s National Health Insurance Research Database (2003–2019), we identified patients aged ≥40 years with COPD receiving specific medications. CM users were matched with nonusers using propensity score matching. The primary outcome was the occurrence of moderate or severe AE within 730 days. Cox proportional hazard models were used to estimate AE risks.

Results

A total of 86,510 CM users were matched with 346,034 nonusers. The incidence of AE was lower in the CM users (9.7%) than in the nonusers (10.7%) as was the incidence of severe AE (2.78% vs. 3.79%). Kaplan–Meier analysis showed significantly lower risks of AE in the CM users (p < 0.001). In multivariate models, CM use was consistently associated with a reduced risk of AE (adjusted hazard ratios: 0.76 to 0.91). Subgroup analyses confirmed these benefits across all subgroups.

Conclusions

Concurrent CM–WM use is associated with a decreased risk of AE in patients with COPD. Integrating CM into conventional management may offer clinical benefits, though further studies are needed to elucidate the underlying mechanisms.

本研究探讨了同时使用中药（CMs）和西药（WMs）是否与慢性阻塞性肺疾病（COPD）患者急性加重（AE）风险降低相关。使用倾向得分匹配将CM使用者与非使用者进行匹配。主要终点为730天内发生中度或重度AE。采用Cox比例风险模型估计AE风险。结果共匹配了86510名CM用户和346034名非CM用户。CM使用者的AE发生率（9.7%）低于非使用者（10.7%），严重AE的发生率（2.78%比3.79%）也低于CM使用者（10.7%）。Kaplan-Meier分析显示CM使用者发生AE的风险显著降低（p < 0.001）。在多变量模型中，CM的使用始终与AE风险降低相关（校正风险比：0.76 - 0.91）。亚组分析证实了所有亚组的这些益处。结论：慢性阻塞性肺病患者同时使用CM-WM与AE风险降低相关。虽然需要进一步的研究来阐明潜在的机制，但将CM纳入常规管理可能会提供临床益处。

{"title":"Concurrent Chinese and Western medication use and risk of acute exacerbations in chronic obstructive pulmonary disease: A national cohort study","authors":"Ming-Chia Lee , Chih-Yuan Wu , Shih-Ming Chen , Ya-Hui Chang , Tzu-Rong Peng , Jin-Hua Chen , Shoko Satake , Jen-Ai Lee , Chih-Hsin Lee , Jann-Yuan Wang","doi":"10.1016/j.imr.2025.101286","DOIUrl":"10.1016/j.imr.2025.101286","url":null,"abstract":"<div><h3>Background</h3><div>This study examined whether concurrent use of Chinese medications (CMs) and Western medications (WMs) was associated with a reduced risk of acute exacerbation (AE) in patients with chronic obstructive pulmonary disease (COPD).</div></div><div><h3>Methods</h3><div>Using Taiwan’s National Health Insurance Research Database (2003–2019), we identified patients aged ≥40 years with COPD receiving specific medications. CM users were matched with nonusers using propensity score matching. The primary outcome was the occurrence of moderate or severe AE within 730 days. Cox proportional hazard models were used to estimate AE risks.</div></div><div><h3>Results</h3><div>A total of 86,510 CM users were matched with 346,034 nonusers. The incidence of AE was lower in the CM users (9.7%) than in the nonusers (10.7%) as was the incidence of severe AE (2.78% vs. 3.79%). Kaplan–Meier analysis showed significantly lower risks of AE in the CM users (<em>p</em> < 0.001). In multivariate models, CM use was consistently associated with a reduced risk of AE (adjusted hazard ratios: 0.76 to 0.91). Subgroup analyses confirmed these benefits across all subgroups.</div></div><div><h3>Conclusions</h3><div>Concurrent CM–WM use is associated with a decreased risk of AE in patients with COPD. Integrating CM into conventional management may offer clinical benefits, though further studies are needed to elucidate the underlying mechanisms.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101286"},"PeriodicalIF":3.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145972788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlicensed medical practice as a public health risk: Implications for Korean Medicine 作为公共健康风险的无证医疗行为：对韩国医学的影响

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-12-23 DOI: 10.1016/j.imr.2025.101285

Yong-Suk Kim

引用次数: 0

Unmeasured corticosteroid burden may mask safety signals in herbal medicine users: A call for dosage adjustment 未测量的皮质类固醇负担可能掩盖草药使用者的安全信号：剂量调整的呼吁

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-12-22 DOI: 10.1016/j.imr.2025.101284

Mengjiao Li , Chenyu Lu , Qiang Zhan

引用次数: 0

Therapeutic mechanisms of acupuncture therapy for acute pain in the emergency department 针刺治疗急诊科急性疼痛的治疗机制

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-12-18 DOI: 10.1016/j.imr.2025.101283

Arya Nielsen , Natalie L. Dyer , Kiran Faryar , Jeffery A. Dusek

Acupuncture has been used for millennia to treat pain and in recent decades included as an evidence-based strategy for comprehensive pain care. More recently, acupuncture has also been used to treat acute peri‑operative pain and acute pain in the Emergency department (ED). While there are models of acupuncture’s effect on chronic pain, the lack of application of those models for acute pain represents a gap in our scientific understanding.

Acupuncture in the ED is a single-session dose intervention. In the context of clarifying significant details of an acupuncture intervention including needle insertion, needle perturbation (to obtain de qi), and needle retention, point specificity, adequate dose using local and distal acupoints, and functional MRI (fMRI) brain studies of acupuncture treatment for pain, a body and auricular model of acupuncture’s specific effects in acute pain reduction is presented. The biomechanisms of body acupuncture are shown to be an interaction between local physiological responses at a needling site and peripheral and central analgesic responses. An auricular model conceptualizes how stimulation of the auricular branch of the vagus nerve also modulates autonomic and central nervous systems. Nonspecific effects of acupuncture are also discussed.

The purpose of this review is to illustrate the biomechanisms of acupuncture for acute pain as a complex intervention that integrates patterns of change at physiological and molecular levels that can inform existing and future effectiveness research and facilitate assimilation of acupuncture in the ED.

几千年来，针灸一直被用于治疗疼痛，最近几十年，针灸被作为一种基于证据的综合疼痛治疗策略。最近，针灸也被用于治疗急性围手术期疼痛和急诊科（ED）的急性疼痛。虽然有针灸治疗慢性疼痛的模型，但缺乏对急性疼痛模型的应用，这表明我们在科学理解上存在差距。针刺在急诊科是一种单次剂量干预。在阐明针刺干预的重要细节的背景下，包括针的插入、针的扰动（以获得德气）、针的保留、穴位特异性、使用局部和远端穴位的适当剂量，以及针灸治疗疼痛的功能MRI （fMRI）脑研究，提出了针灸在急性疼痛减轻中的特异性作用的身体和耳穴模型。体针的生物机制被证明是针刺部位局部生理反应与外周和中枢镇痛反应之间的相互作用。耳穴模型概念化了迷走神经耳穴分支的刺激如何调节自主神经系统和中枢神经系统。针刺的非特异性效应也进行了讨论。这篇综述的目的是阐明针灸治疗急性疼痛的生物机制，作为一种综合了生理和分子水平变化模式的复杂干预措施，可以为现有和未来的有效性研究提供信息，并促进针灸在ED中的同化。

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引用次数: 0

Traditional Chinese medicine for non-small cell lung carcinoma: An evidence mapping 中药治疗非小细胞肺癌：证据图谱

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-12-17 DOI: 10.1016/j.imr.2025.101281

Zelei Dai , Xi Chen , Nian Li , Chenfeng Tan , Yonggang Zhang , Ying Wang , Renjie Zhao , Kefan Li , Mike Clarke , Lei Liu , Lingmin Chen

Background

Although many systematic reviews and meta-analyses have explored Traditional Chinese Medicine (TCM) for non-small cell lung carcinoma (NSCLC), uncertainty remains about the pooled efficacy, safety, and methodological quality of these reviews and the interventions they assessed. This study aimed to address this gap by analyzing TCM treatments for NSCLC using evidence mapping.

Methods

A comprehensive search across six databases identified relevant systematic reviews and meta-analyses up to August 2025. The AMSTAR-2 tool was used to assess methodological quality, and Python was used for statistical analysis and visualization. Evidence maps were created to group reviews by treatment types (chemotherapy, targeted therapy, radiotherapy, immunotherapy and supportive care) and by specific outcomes such as objective response rate (ORR), leukopenia, and quality of life (QoL).

Results

Out of 196 systematic reviews, 42 TCM interventions and 55 outcomes were identified. Most reviews examined TCM combined with chemotherapy, particularly Aidi, Kanglaite, and Shenqi Fuzheng injections. These combinations showed potential benefits in ORR, QoL, and chemotherapy-induced leukopenia. TCM combined with targeted therapies, such as EGFR-TKIs and Astragalus, also indicated benefits in progression-free survival and immune function. However, most systematic reviews were of "critically low" quality, limiting evidence reliability.

Conclusion

While TCM shows promise in enhancing conventional NSCLC treatments, high-quality, rigorously conducted randomised trials and reviews are essential to confirm these findings and guide clinical integration.

尽管许多系统综述和荟萃分析已经探讨了中医药治疗非小细胞肺癌（NSCLC），但这些综述及其评估的干预措施的综合疗效、安全性和方法学质量仍然存在不确定性。本研究旨在通过使用证据图谱分析非小细胞肺癌的中医治疗来解决这一空白。方法对截至2025年8月的6个数据库进行综合检索，确定相关的系统综述和荟萃分析。使用AMSTAR-2工具评估方法学质量，使用Python进行统计分析和可视化。根据治疗类型（化疗、靶向治疗、放疗、免疫治疗和支持治疗）和特定结果（如客观缓解率（ORR）、白细胞减少率和生活质量（QoL））创建证据图进行分组评价。结果在196个系统评价中，确定了42个中医干预措施和55个结局。大多数评论研究了中药联合化疗，特别是爱地、康莱特和参芪扶正注射液。这些组合在ORR、QoL和化疗诱导的白细胞减少方面显示出潜在的益处。中药联合靶向治疗，如EGFR-TKIs和黄芪，也显示出在无进展生存和免疫功能方面的益处。然而，大多数系统评价的质量“极低”，限制了证据的可靠性。结论：虽然中医药在加强传统非小细胞肺癌治疗方面有希望，但高质量、严格进行的随机试验和评价对于证实这些发现和指导临床整合至关重要。

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引用次数: 0

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