Biochemical, structural characterization and assessing the biological effects of cinnamon nanoparticles

IF 2.5 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology and Bioprocess Engineering Pub Date : 2024-02-13 DOI:10.1007/s12257-024-00004-w

Zahra Sabouri, Neda Shakour, Mohammad Sabouri, Samaneh Sadat Tabrizi Hafez Moghaddas, Majid Darroudi

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Abstract

The natural polyphenolic materials that cinnamon contains are well known for their different biological applications and have a wide variety of pharmacological and therapeutic attributes. Bioactive and harmless cinnamon nanoparticles (cinnamon-NPs) can be anticancer and antidiabetic agents. For this purpose, water-soluble cinnamon-NPs were synthesized using the hydrothermal technique for the first time and in vitro studies were performed to investigate their anti-diabetic effects. The outcomes of morphology, size, and stability of cinnamon-NPs were described through Transmission electron microscopy (TEM), X-ray diffraction (XRD), Dynamic light scattering/Zeta (DLS/Zeta), Ultraviolet–visible (UV–Vis), and Fourier transform infrared (FTIR) analyses. The morphology of cinnamon-NPs was spherical and their average size was about 14.8 nm. Furthermore, the glucose consumption assay results revealed that compound cinnamon-NPs at 1.0 and 10 µM significantly lowered glucose levels (p < 0.05) in HepG2 cells exposed to 11.0 and 22.0 mM of glucose compared with standard (pioglitazone) and control groups. Therefore, the utilization of spherical NPs suspended in water could be useful for investigating therapeutic applications.

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肉桂纳米粒子的生物化学、结构特征和生物效应评估

肉桂所含的天然多酚物质因其不同的生物应用而广为人知，并具有多种药理和治疗特性。具有生物活性且无害的肉桂纳米粒子（cinnamon-NPs）可作为抗癌剂和抗糖尿病剂。为此，研究人员首次采用水热技术合成了水溶性肉桂纳米粒子，并进行了体外研究以探究其抗糖尿病作用。通过透射电子显微镜（TEM）、X射线衍射（XRD）、动态光散射/Zeta（DLS/Zeta）、紫外可见光（UV-Vis）和傅立叶变换红外（FTIR）分析，对肉桂-NPs的形态、尺寸和稳定性进行了描述。肉桂-NPs 的形态呈球形，平均粒径约为 14.8 纳米。此外，葡萄糖消耗试验结果表明，与标准组（吡格列酮）和对照组相比，1.0 µM和10 µM的复合肉桂-NPs能显著降低暴露于11.0 mM和22.0 mM葡萄糖的HepG2细胞的葡萄糖水平（p < 0.05）。因此，利用悬浮在水中的球形 NPs 可用于研究治疗应用。

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来源期刊

Biotechnology and Bioprocess Engineering 工程技术-生物工程与应用微生物

CiteScore

5.00

自引率

12.50%

发文量

审稿时长

3 months

期刊介绍： Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.