Synthesis, structural characterization, and cytotoxicity of nickel(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridines

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-02-16 DOI:10.1007/s11243-024-00573-y

Ekaterina A. Ermakova, Yuliya A. Golubeva, Ksenia S. Smirnova, Lyubov S. Klyushova, Dmitriy G. Sheven’, Elizaveta V. Lider

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Abstract

Nickel(II) complexes of 1H-tetrazol-5-acetic acid (H₂L) and oligopyridines (1,10-phenanthroline /2,2’-bipyridine derivatives) have been synthesized and characterized by physicochemical methods (elemental and thermogravimetric analysis, powder X-ray diffraction, and IR spectroscopy). The behavior of the complexes in solution was studied by UV–Vis spectroscopy, conductometry, and mass spectrometry. The stability of the complexes over 48 h in aqueous solution and in phosphate-buffered saline was demonstrated using UV–Vis spectroscopy. These compounds were investigated for their cytotoxic and cytostatic activity against HepG2 (hepatocellular carcinoma), and Hep2 (larynx carcinoma) human cancer cell lines. Cytotoxicity was also studied on human non-cancerous cell line MRC-5 (lung fibroblast). All the compounds did not show cytotoxic activity against the tested cell lines in 1–50-µM concentration range. However, compounds showed a cytostatic effect against HepG2 and Hep2 cell lines. The most pronounced cytostatic properties were found for the complex [Ni(dmphen)₂L]·2C₂H₅OH·2H₂O (1). In addition, we report three new crystal structures: [Ni(phen)₂L]·H₂O, [Ni(dmbipy)₂L]·2C₂H₅OH, and [Ni(dmphen)₂L]·2C₂H₅OH·2H₂O, where L^2– behaves as a bidentate ligand which is coordinated to the Ni(II) ion via N,O atoms.

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镍（II）与 1H-四氮唑-5-乙酸和低聚吡啶配合物的合成、结构表征和细胞毒性

研究人员合成了 1H-四唑-5-乙酸（H2L）和寡吡啶（1,10-菲罗啉/2,2'-联吡啶衍生物）的镍（II）配合物，并通过理化方法（元素和热重分析、粉末 X 射线衍射和红外光谱）对其进行了表征。紫外可见光谱法、电导率测定法和质谱法研究了这些配合物在溶液中的行为。紫外可见光谱法证明了复合物在水溶液和磷酸盐缓冲盐水中 48 小时的稳定性。研究了这些化合物对 HepG2（肝癌）和 Hep2（喉癌）人类癌细胞系的细胞毒性和细胞抑制活性。此外，还研究了这些化合物对人类非癌细胞株 MRC-5（肺成纤维细胞）的细胞毒性。在 1-50-µM 浓度范围内，所有化合物均未显示出对受试细胞株的细胞毒性活性。但是，这些化合物对 HepG2 和 Hep2 细胞株有细胞抑制作用。复合物[Ni(dmphen)2L]-2C2H5OH-2H2O（1）具有最明显的细胞抑制特性。此外，我们还报告了三种新的晶体结构：[其中 L2- 是一种双齿配体，通过 N、O 原子与 Ni(II) 离子配位。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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