Synthesis, structural characterization, and cytotoxicity of nickel(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridines

IF 1.6 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Transition Metal Chemistry Pub Date : 2024-02-16 DOI:10.1007/s11243-024-00573-y

Ekaterina A. Ermakova, Yuliya A. Golubeva, Ksenia S. Smirnova, Lyubov S. Klyushova, Dmitriy G. Sheven’, Elizaveta V. Lider

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Abstract

Nickel(II) complexes of 1H-tetrazol-5-acetic acid (H₂L) and oligopyridines (1,10-phenanthroline /2,2’-bipyridine derivatives) have been synthesized and characterized by physicochemical methods (elemental and thermogravimetric analysis, powder X-ray diffraction, and IR spectroscopy). The behavior of the complexes in solution was studied by UV–Vis spectroscopy, conductometry, and mass spectrometry. The stability of the complexes over 48 h in aqueous solution and in phosphate-buffered saline was demonstrated using UV–Vis spectroscopy. These compounds were investigated for their cytotoxic and cytostatic activity against HepG2 (hepatocellular carcinoma), and Hep2 (larynx carcinoma) human cancer cell lines. Cytotoxicity was also studied on human non-cancerous cell line MRC-5 (lung fibroblast). All the compounds did not show cytotoxic activity against the tested cell lines in 1–50-µM concentration range. However, compounds showed a cytostatic effect against HepG2 and Hep2 cell lines. The most pronounced cytostatic properties were found for the complex [Ni(dmphen)₂L]·2C₂H₅OH·2H₂O (1). In addition, we report three new crystal structures: [Ni(phen)₂L]·H₂O, [Ni(dmbipy)₂L]·2C₂H₅OH, and [Ni(dmphen)₂L]·2C₂H₅OH·2H₂O, where L^2– behaves as a bidentate ligand which is coordinated to the Ni(II) ion via N,O atoms.

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镍（II）与 1H-四氮唑-5-乙酸和低聚吡啶配合物的合成、结构表征和细胞毒性

研究人员合成了 1H-四唑-5-乙酸（H2L）和寡吡啶（1,10-菲罗啉/2,2'-联吡啶衍生物）的镍（II）配合物，并通过理化方法（元素和热重分析、粉末 X 射线衍射和红外光谱）对其进行了表征。紫外可见光谱法、电导率测定法和质谱法研究了这些配合物在溶液中的行为。紫外可见光谱法证明了复合物在水溶液和磷酸盐缓冲盐水中 48 小时的稳定性。研究了这些化合物对 HepG2（肝癌）和 Hep2（喉癌）人类癌细胞系的细胞毒性和细胞抑制活性。此外，还研究了这些化合物对人类非癌细胞株 MRC-5（肺成纤维细胞）的细胞毒性。在 1-50-µM 浓度范围内，所有化合物均未显示出对受试细胞株的细胞毒性活性。但是，这些化合物对 HepG2 和 Hep2 细胞株有细胞抑制作用。复合物[Ni(dmphen)2L]-2C2H5OH-2H2O（1）具有最明显的细胞抑制特性。此外，我们还报告了三种新的晶体结构：[其中 L2- 是一种双齿配体，通过 N、O 原子与 Ni(II) 离子配位。

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来源期刊

Transition Metal Chemistry 化学-无机化学与核化学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

1.3 months

期刊介绍： Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc. Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.