A novel stochastic Hepatitis B virus epidemic model with second-order multiplicative α-stable noise and real data

IF 1.2 4区 数学 Q1 MATHEMATICS Acta Mathematica Scientia Pub Date : 2024-03-01 DOI:10.1007/s10473-024-0220-1
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Abstract

This work presents an advanced and detailed analysis of the mechanisms of hepatitis B virus (HBV) propagation in an environment characterized by variability and stochas-ticity. Based on some biological features of the virus and the assumptions, the corresponding deterministic model is formulated, which takes into consideration the effect of vaccination. This deterministic model is extended to a stochastic framework by considering a new form of disturbance which makes it possible to simulate strong and significant fluctuations. The long-term behaviors of the virus are predicted by using stochastic differential equations with second-order multiplicative α-stable jumps. By developing the assumptions and employing the novel theoretical tools, the threshold parameter responsible for ergodicity (persistence) and extinction is provided. The theoretical results of the current study are validated by numerical simulations and parameters estimation is also performed. Moreover, we obtain the following new interesting findings: (a) in each class, the average time depends on the value of α; (b) the second-order noise has an inverse effect on the spread of the virus; (c) the shapes of population densities at stationary level quickly changes at certain values of α. The last three conclusions can provide a solid research base for further investigation in the field of biological and ecological modeling.

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具有二阶乘法 α 稳定噪声和真实数据的新型随机乙型肝炎病毒流行模型
摘要 本研究对乙型肝炎病毒(HBV)在具有可变性和随机性特征的环境中的传播机制进行了深入细致的分析。根据病毒的一些生物学特征和假设,建立了相应的确定性模型,其中考虑了疫苗接种的影响。通过考虑一种新的干扰形式,这种确定性模型被扩展到随机框架,从而有可能模拟强烈和显著的波动。通过使用具有二阶乘法 α 稳定跃迁的随机微分方程来预测病毒的长期行为。通过建立假设和使用新颖的理论工具,提供了导致遍历性(持续性)和灭绝的阈值参数。本研究的理论结果得到了数值模拟的验证,并进行了参数估计。此外,我们还获得了以下有趣的新发现:(a) 在每个类别中,平均时间取决于 α 值;(b) 二阶噪声对病毒传播有反向影响;(c) 在固定水平上,种群密度的形状在一定的 α 值下迅速变化。 最后三个结论可为生物和生态建模领域的进一步研究提供坚实的研究基础。
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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
2614
审稿时长
6 months
期刊介绍: Acta Mathematica Scientia was founded by Prof. Li Guoping (Lee Kwok Ping) in April 1981. The aim of Acta Mathematica Scientia is to present to the specialized readers important new achievements in the areas of mathematical sciences. The journal considers for publication of original research papers in all areas related to the frontier branches of mathematics with other science and technology.
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