Protective Effect of Echinops persicus Extract on Oxidative Stress Enzymes in Various Rat Tissues after Carbon Tetrachloride Intoxication

IF 0.5 4区生物学 Q4 BIOLOGY Biology Bulletin Pub Date : 2024-02-09 DOI:10.1134/s1062359023602562

Maryam Soori, Mohammad Taghi Goodarzi, Hassan Mehrad-Majd, Hossein Abbaspour, Seyed Hossein Hashemi, Zeynab Soori

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Abstract

Medicinal plants have been proposed as potential therapeutic agents for the treatment and prevention of various oxidative stress-related disorders. The purpose of this study was to investigate the effect of Echinops persicus (Ec.P) extract on catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in different rat tissues after carbon tetrachloride (CCl₄) intoxication. A total of 38 rats weighing 180–210 g were randomly divided into eight groups of five. Rats in group 1 received only a standard diet and served as the control group, those in group 2 were given olive oil, and the rats in group 3 received olive oil + CCl₄. Groups 4 to 8 were experimental groups. Rats of the experimental groups received olive oil + CCl₄ in a ratio of 1 : 1 v/v daily for 7 days. After this period, vitamins C and E were given in 10 mg/kg doses to groups 4 and 5, respectively. Rats of groups 6, 7, and 8 were also treated with 0.5, 1, and 2 g/kg body weight of Ec.P extract, respectively, for the next seven days. The kidney, liver, and heart supernatants of all rats were used to measure enzyme activities. Results: Decreased activity of SOD, CAT, and GPx were found in the liver, kidney, and heart after CCl₄ intoxication. The aqueous extract of Ec.P showed a significant protective effect by elevating antioxidant enzyme activities, compared to vitamins C and E in a dose and tissue-dependent manner. The obtained results of the current study highlighted the protective effect of Ec.P extract on antioxidant enzyme activities. The Ec.P could probably be significant in treating oxidative stress-related disorders.

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棘果提取物对四氯化碳中毒后大鼠各种组织中氧化应激酶的保护作用

摘要药用植物被认为是治疗和预防各种氧化应激相关疾病的潜在治疗剂。本研究旨在探讨棘果（Echinops persicus，Ec.P）提取物对四氯化碳（CCl4）中毒后不同大鼠组织中过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性的影响。38 只体重 180-210 克的大鼠被随机分为 8 组，每组 5 只。第 1 组大鼠只摄入标准饮食，作为对照组；第 2 组大鼠摄入橄榄油；第 3 组大鼠摄入橄榄油 + CCl4。第 4 至第 8 组为实验组。实验组大鼠每天按 1 : 1 v/v 的比例摄入橄榄油 + 氯化物，持续 7 天。之后，给第 4 组和第 5 组大鼠分别服用剂量为 10 毫克/千克的维生素 C 和维生素 E。第 6、第 7 和第 8 组大鼠在接下来的 7 天中也分别接受了每公斤体重 0.5、1 和 2 克的 Ec.P 提取物治疗。所有大鼠的肾脏、肝脏和心脏上清液均用于测量酶活性。结果显示发现 CCl4 中毒后，大鼠肝脏、肾脏和心脏中的 SOD、CAT 和 GPx 活性降低。与维生素 C 和 E 相比，Ec.P 的水提取物通过提高抗氧化酶的活性，以剂量和组织依赖的方式显示出显著的保护作用。本研究的结果突出了蜕皮激素提取物对抗氧化酶活性的保护作用。Ec.P可能对治疗氧化应激相关疾病有重要作用。

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来源期刊

Biology Bulletin 生物-生物学

CiteScore

0.70

自引率

20.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biology Bulletin (Izvestiya Rossiiskoi Akademii Nauk – Seriya Biologicheskaya) is an interdisciplinary journal of general biology. It focuses on fundamental studies in the fields of cell biology, biochemistry, zoology, botany, physiology, and ecology. This journal publishes current materials of experimental studies and surveys on current problems in general biology. It also publishes information on scientific conferences and new books in the fields of general biology.