Drug delivery in thermo-responsive silicone catheters by grafting of N-vinylcaprolactam using gamma radiation

IF 1.8 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY MRS Communications Pub Date : 2024-02-08 DOI:10.1557/s43579-024-00528-5
Manuel U. Ramirez-Fuentes, Lorena Duarte-Peña, Emilio Bucio
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Abstract

Radiation-induced graft polymerization of poly(N-vinylcaprolactam) onto silicone catheters by direct irradiation method was studied. The effects of the irradiation dose, as well as the monomer concentration, on the grafting efficiency were studied. The conditions for achieving maximum grafting yield were observed at 30% of monomer concentration in toluene at 50 kGy. The graft polymerization was examined by different characterization methods, including measurements such as thermogravimetric analysis, infrared, water contact angle, and swelling. The temperature-responsive behavior of smart grafted copolymer was studied by swelling at different temperatures. Differently from pristine silicone catheter, the N-vinylcaprolactam-grafted catheters were able to load vancomycin and sustain the release for 30 h.

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利用伽马射线接枝 N-乙烯基己内酰胺在热响应硅导管中给药
通过直接辐照法研究了聚(N-乙烯基己内酰胺)在硅树脂导管上的辐射诱导接枝聚合。研究了辐照剂量和单体浓度对接枝效率的影响。在单体浓度为 30% 的甲苯中,辐照剂量为 50 kGy 时,接枝率最高。接枝聚合采用了不同的表征方法,包括热重分析、红外线、水接触角和溶胀等测量方法。通过在不同温度下溶胀,研究了智能接枝共聚物的温度响应行为。与原始硅胶导管不同,N-乙烯基己内酰胺接枝导管能够负载万古霉素并持续释放30小时。
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来源期刊
MRS Communications
MRS Communications MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
2.60
自引率
10.50%
发文量
166
审稿时长
>12 weeks
期刊介绍: MRS Communications is a full-color, high-impact journal focused on rapid publication of completed research with broad appeal to the materials community. MRS Communications offers a rapid but rigorous peer-review process and time to publication. Leveraging its access to the far-reaching technical expertise of MRS members and leading materials researchers from around the world, the journal boasts an experienced and highly respected board of principal editors and reviewers.
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