Five Himalayan weeds as potential bioresources for bioactive agents: toxic compounds to valuable scaffolds

IF 7.3 2区 生物学 Q1 PLANT SCIENCES Phytochemistry Reviews Pub Date : 2024-02-14 DOI:10.1007/s11101-024-09921-3
Ekta Bala, Varun Aggarwal, Pawan Kumar, Rohit Sharma,  Saima, Manickam Selvaraj, Mohammed A. Assiri, Praveen Kumar Verma
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Abstract

Natural products are highly prevalent in Himalayan region clustered in medicinal and aromatic plants including weeds. Toxic weed plants are of serious concerns due to their hazardous effects to humans, environment, and animals. The cause of toxicity of these toxic weed plants is due to the presence of toxic secondary metabolites. Several toxic secondary metabolites have been reported and characterised in these weed plants. There are several functionalities (toxicophores) in these secondary metabolites which have been identified responsible for the toxic effects of these naturally occurring molecules. The eradication of these toxic weed plants is the major strategy to minimize the hazardous effects. Albeit, there are possibilities for the utilization of these abundantly available toxic secondary metabolites as the valuable scaffolds by their synthetic modification to alter their toxicophores. Herein, we have compiled the reports based on the synthetic modification of the toxicophores present in these secondary metabolites and evaluated for their various pharmacological potential. Several molecules have been illustrated which are present in good amount in the toxic weeds and utilised as valuable bioactive scaffolds through intervention of synthetic modifications. The current review will be highly beneficial for the future developments utilising the abundantly available toxic molecules isolated from toxic weed plants and will also provide the alternative and effective strategy for the utilization of these toxic weeds.

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作为生物活性剂潜在生物资源的五种喜马拉雅杂草:从有毒化合物到有价值的支架
喜马拉雅地区的天然产品主要集中在药用植物和芳香植物中,包括杂草。由于有毒杂草植物对人类、环境和动物造成危害,因此备受关注。造成这些有毒杂草植物毒性的原因是有毒次生代谢物的存在。据报道,这些杂草植物中存在多种有毒的次级代谢物,并对其进行了表征。在这些次生代谢物中,有几种功能性物质(发毒体)已被确认是导致这些天然分子产生毒性作用的原因。根除这些有毒杂草植物是将其危害影响降至最低的主要策略。尽管如此,我们仍有可能利用这些大量存在的有毒次生代谢物作为宝贵的支架,通过对其进行合成修饰来改变其毒性。在此,我们汇编了有关合成修饰这些次生代谢物中的毒腺并评估其各种药理潜力的报告。其中说明了一些分子,它们大量存在于有毒杂草中,并通过人工合成修饰成为有价值的生物活性支架。当前的综述将对未来利用从有毒杂草植物中分离出的大量有毒分子进行开发大有裨益,同时也将为利用这些有毒杂草提供可供选择的有效策略。
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来源期刊
Phytochemistry Reviews
Phytochemistry Reviews PLANT SCIENCES-
CiteScore
16.30
自引率
2.60%
发文量
54
审稿时长
2 months
期刊介绍: Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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