Bastian Engel, Ahmed Alaswad, Alejandro Campos-Murguia, Martijn Zoodsma, Anne Klingbeil, Kinan Chihab, Emily A. Bosselmann, Sophia Heinrich, Björn Hartleben, Danny D. Jonigk, Murielle Verboom, Michael Hallensleben, Robert Geffers, Heiner Wedemeyer, Cheng-Jian Xu, Elmar Jaeckel, Yang Li, Richard Taubert
{"title":"Molecular signatures of chronic antibody-mediated rejection in human liver transplants","authors":"Bastian Engel, Ahmed Alaswad, Alejandro Campos-Murguia, Martijn Zoodsma, Anne Klingbeil, Kinan Chihab, Emily A. Bosselmann, Sophia Heinrich, Björn Hartleben, Danny D. Jonigk, Murielle Verboom, Michael Hallensleben, Robert Geffers, Heiner Wedemeyer, Cheng-Jian Xu, Elmar Jaeckel, Yang Li, Richard Taubert","doi":"10.1101/2024.02.08.24302515","DOIUrl":null,"url":null,"abstract":"<strong>Background&Aims</strong> The role of antibody-mediated rejection (ABMR) after liver transplantation (LT) remains controversial. Chronic ABMR (cABMR) is often subclinical and potentially missed without surveillance biopsies (svLbx) which are not established in most LT centers. Transcriptome analysis previously characterized molecular changes in T cell-mediated rejection (TCMR) after solid organ transplantation. We aimed to identify molecular cABMR signatures after LT for a more comprehensive understanding of cABMR.","PeriodicalId":501561,"journal":{"name":"medRxiv - Transplantation","volume":"30 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Transplantation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.02.08.24302515","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background&Aims The role of antibody-mediated rejection (ABMR) after liver transplantation (LT) remains controversial. Chronic ABMR (cABMR) is often subclinical and potentially missed without surveillance biopsies (svLbx) which are not established in most LT centers. Transcriptome analysis previously characterized molecular changes in T cell-mediated rejection (TCMR) after solid organ transplantation. We aimed to identify molecular cABMR signatures after LT for a more comprehensive understanding of cABMR.
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