POSSIBILITIES OF USING TOPICAL RETINOIDS AND AZELAIC ACID IN ACNE THERAPY

Q4 Medicine Vestnik dermatologii i venerologii Pub Date : 2024-02-15 DOI:10.25208/vdv11661
O. Katkhanova, Galina Nikolaevna Burtseva, Anastasia Vadimovna Solovyova
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Abstract

Background. Acne therapy is an urgent problem of dermatocosmetology. The clinical manifestations of dermatosis can be alleviated, and its long-term consequences can be prevented by early diagnosis and timely treatment, which affects all parts of the pathogenesis in a multifaceted way. The aim of the study was to compare the clinical efficacy and safety of the use of monotherapy of 0.1% adapalene cream (Adaklin) with combined external therapy of 0.1% adapalene cream (Adaklin) with 20% azelaic acid cream (Azix-Derm) in the treatment of mild to moderate acne. Methods. 50 patients aged 12 to 50 years with mild to moderate acne were under observation. Patients group 1 of observation (n = 16), were prescribed Adaklin cream, 1 time per day (evening) against the background of skin care. In the group 2 with mild to moderate papulo-pustular acne and post-inflammatory changes, patients were prescribed a combination of 0.1% adapalene cream and 20% azelaic acid cream Results. Total clinical remission after 6 months therapy was achieved in 70% of cases, a significant improvement in 28%.In group 1 clinical recovery was obtained in 48% of patients, a significant improvement in 50%, in patients from the group 2 clinical recovery was recorded in 58%, significant improvement in 36%; Combined treatment was able to achieve regression of dyschromia in 46% of patients, pseudoatorofy in 22%, which significantly improved the results of therapy and made it possible to achieve a good cosmetic effect. Conclusion. The combined use of drugs for external use of adapalene and AK in the treatment of papulo-pustular acne of mild and AK in the treatment of papulo-pustular acne of mild and moderate severity can significantly increase the effectiveness of treatment, achieve a stable clinical effect and remission of the disease, as well as improve the quality of life of patients.
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在痤疮治疗中使用外用维甲酸和杜鹃花酸的可能性
背景。痤疮治疗是皮肤美容学亟待解决的问题。皮肤病的临床表现可以通过早期诊断和及时治疗得到缓解,其长期后果可以通过多方面影响发病机制的各个环节来预防。本研究旨在比较使用 0.1%阿达帕林乳膏(Adaklin)单一疗法与 0.1%阿达帕林乳膏(Adaklin)联合 20%杜鹃花酸乳膏(Azix-Derm)外用疗法治疗轻中度痤疮的临床疗效和安全性。研究方法观察 50 名年龄在 12 至 50 岁之间的轻中度痤疮患者。观察组 1 的患者(16 人)在进行皮肤护理的同时,每天(晚上)使用 1 次阿达克林乳膏。第 2 组患者为轻度至中度丘疹脓疱型痤疮和炎症后变化,处方为 0.1% 阿达帕林乳膏和 20% 杜鹃花酸乳膏。第 1 组有 48% 的患者临床痊愈,50% 的患者明显好转,第 2 组有 58% 的患者临床痊愈,36% 的患者明显好转;通过联合治疗,46% 的患者色素沉着消退,22% 的患者假性色素沉着消退,从而显著改善了治疗效果,并取得了良好的美容效果。结论阿达帕林与AK联合外用药物治疗轻、中度丘疹性脓疱性痤疮,能够明显提高治疗效果,达到临床疗效稳定、病情缓解的目的,同时还能提高患者的生活质量。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
40
审稿时长
8 weeks
期刊最新文献
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