Collagen‐cellulose‐poly(l‐lactide) scaffold by electrospinning and plasma‐assisting fabrication for bone tissue engineering applications

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-02-15 DOI:10.1002/ppap.202300209

Zulka Ziblim, B. Thapsukhon, Vachira Choommongkol, Dhreerawan Boonyawan, K. Inthanon, Orawan Khantamat, J. Ruangsuriya

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Abstract

Novel biomaterials suitable for bone tissue engineering are currently in demand, and reformulating natural and synthetic biomaterials has caught scientists' attention. Cellulose and collagen have been utilized in biomedical fields. This research aimed to fabricate collagen‐cellulose‐poly(l‐lactide) (Col‐Cel‐PLL) scaffold using collagen, cellulose, and poly( l‐lactide) through electrospinning and radiofrequency plasma treatment and to examine the scaffold's physicochemical and biological properties. Fourier transform infrared spectroscopy revealed its chemistry, and scanning electron microscopy showed fine interconnecting microfibrous fibers; it was super‐hydrophilic with low crystallinity (25.59%) and great Young's modulus (163.940 ± 8.008 MPa), and it was reasonably degraded. Regarding biological properties, the scaffold was biocompatible by supporting cell attachment and viability. Cells on the Col‐Cel‐PLL produced high total protein levels and collagen deposition. However, the alkaline phosphatase activity was significantly low.

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通过电纺丝和等离子辅助制造胶原-纤维素-聚（l-内酰胺）支架，用于骨组织工程应用

目前，适合骨组织工程的新型生物材料需求量很大，重新配制天然和合成生物材料已引起科学家的关注。纤维素和胶原蛋白已被应用于生物医学领域。本研究旨在利用胶原蛋白、纤维素和聚(l-内酰胺)通过电纺丝和射频等离子处理制成胶原-纤维素-聚(l-内酰胺)（Col-Cel-PLL）支架，并研究支架的物理化学和生物学特性。傅立叶变换红外光谱显示了其化学性质，扫描电子显微镜显示了细微的相互连接的微纤维；它具有超亲水性、低结晶度（25.59%）和高杨氏模量（163.940 ± 8.008 MPa），而且降解合理。在生物特性方面，该支架具有良好的生物相容性，支持细胞附着和存活。Col-Cel-PLL上的细胞可产生较高的总蛋白水平和胶原沉积。不过，碱性磷酸酶的活性明显较低。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.