Evaluating the Effect of Moringa concanensis on Aluminium Chloride-Induced Anemia in Wistar Rats

Q4 Pharmacology, Toxicology and Pharmaceutics Journal of Natural Remedies Pub Date : 2024-02-01 DOI:10.18311/jnr/2024/34553
Rahul Kumar, M. G. Hariprasad, Moqbel Ali Moqbel Redhwan, Vidyabhushan Yadav, Apurwa Dhavale, Sourav Guha
{"title":"Evaluating the Effect of Moringa concanensis on Aluminium Chloride-Induced Anemia in Wistar Rats","authors":"Rahul Kumar, M. G. Hariprasad, Moqbel Ali Moqbel Redhwan, Vidyabhushan Yadav, Apurwa Dhavale, Sourav Guha","doi":"10.18311/jnr/2024/34553","DOIUrl":null,"url":null,"abstract":"Anemia, a widespread global health challenge, can be induced through exposure to deleterious substances such as aluminum chloride. The present investigation explores the potential ameliorative effects of Moringa concanensis - a plant acknowledged for its myriad medicinal virtues-against anemia induced by aluminium chloride. The study objective was to scrutinize the impact of Moringa concanensis on aluminium chloride-induced anemia in Wistar rats. In the experimental design, thirty Wistar rats were randomly distributed into five distinct groups: a normal control group (untreated), a diseased control group (administered with aluminium chloride at a dose of 0.5 mg/kg body weight), a standard group (treated with Ferrous ascorbate at 30 mg/kg body weight), and two groups receiving low and high doses of Moringa concanensis (200 mg/kg and 400 mg/kg body weight, respectively). All groups, with the exception of the normal control, were exposed to aluminium chloride at a dosage of 0.5 mg/kg body weight over a span of 14 days. Hematological indicators were evaluated following standard methodologies, serum ferritin levels were assessed through Electrochemiluminescence immunoassay (ECLIA), and vitamin B12 concentration was quantified using atomic absorption spectroscopy. Furthermore, histopathological alterations were identified through Hematoxylin and Eosin staining procedures. Statistical data were interpreted through one-way ANOVA, succeeded by Tukey’s post hoc analysis, considering a p-value below 0.05 as statistically significant. Upon 21 days of continuous treatment with Moringa concanensis, both low and high-dose groups exhibited elevation in hematological parameters, serum ferritin, total iron-binding capacity, and vitamin B12 in comparison to the diseased control group. Noteworthy findings were observed in the high-dose group (400 mg/kg body weight), displaying significant improvement compared to the diseased control group (P<0.001). Remarkably, the high-dose regimen restored hematological parameters to baseline levels and mirrored the efficacy observed with the standard drug (Ferrous ascorbate). These empirical findings underscore the potential of Moringa concanensis as a promising therapeutic candidate for the alleviation of aluminium chloride-induced anemia. These results pave the way for future research endeavors to unravel the precise mechanisms driving these protective effects.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"421 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Remedies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18311/jnr/2024/34553","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0

Abstract

Anemia, a widespread global health challenge, can be induced through exposure to deleterious substances such as aluminum chloride. The present investigation explores the potential ameliorative effects of Moringa concanensis - a plant acknowledged for its myriad medicinal virtues-against anemia induced by aluminium chloride. The study objective was to scrutinize the impact of Moringa concanensis on aluminium chloride-induced anemia in Wistar rats. In the experimental design, thirty Wistar rats were randomly distributed into five distinct groups: a normal control group (untreated), a diseased control group (administered with aluminium chloride at a dose of 0.5 mg/kg body weight), a standard group (treated with Ferrous ascorbate at 30 mg/kg body weight), and two groups receiving low and high doses of Moringa concanensis (200 mg/kg and 400 mg/kg body weight, respectively). All groups, with the exception of the normal control, were exposed to aluminium chloride at a dosage of 0.5 mg/kg body weight over a span of 14 days. Hematological indicators were evaluated following standard methodologies, serum ferritin levels were assessed through Electrochemiluminescence immunoassay (ECLIA), and vitamin B12 concentration was quantified using atomic absorption spectroscopy. Furthermore, histopathological alterations were identified through Hematoxylin and Eosin staining procedures. Statistical data were interpreted through one-way ANOVA, succeeded by Tukey’s post hoc analysis, considering a p-value below 0.05 as statistically significant. Upon 21 days of continuous treatment with Moringa concanensis, both low and high-dose groups exhibited elevation in hematological parameters, serum ferritin, total iron-binding capacity, and vitamin B12 in comparison to the diseased control group. Noteworthy findings were observed in the high-dose group (400 mg/kg body weight), displaying significant improvement compared to the diseased control group (P<0.001). Remarkably, the high-dose regimen restored hematological parameters to baseline levels and mirrored the efficacy observed with the standard drug (Ferrous ascorbate). These empirical findings underscore the potential of Moringa concanensis as a promising therapeutic candidate for the alleviation of aluminium chloride-induced anemia. These results pave the way for future research endeavors to unravel the precise mechanisms driving these protective effects.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
评估辣木对氯化铝诱发的 Wistar 大鼠贫血症的影响
贫血症是全球普遍存在的健康问题,可通过接触氯化铝等有害物质而诱发。本研究探讨了海桑--一种被公认具有多种药用价值的植物--对氯化铝诱发的贫血症的潜在改善作用。研究目的是仔细观察 Moringa concanensis 对氯化铝诱发的 Wistar 大鼠贫血症的影响。在实验设计中,30 只 Wistar 大鼠被随机分为五个不同的组别:正常对照组(未经处理)、疾病对照组(氯化铝剂量为 0.5 毫克/千克体重)、标准组(抗坏血酸亚铁剂量为 30 毫克/千克体重)以及接受低剂量和高剂量 Moringa concanensis(分别为 200 毫克/千克和 400 毫克/千克体重)的两个组。除正常对照组外,其他各组均在 14 天内接触氯化铝,剂量为 0.5 毫克/千克体重。血液学指标按照标准方法进行评估,血清铁蛋白水平通过电化学发光免疫分析法(ECLIA)进行评估,维生素 B12 浓度通过原子吸收光谱法进行量化。此外,还通过苏木精和伊红染色法确定组织病理学改变。统计数据通过单因素方差分析进行解释,然后进行Tukey's事后分析,认为P值低于0.05为具有统计学意义。与疾病对照组相比,在连续服用 21 天的辣木后,低剂量组和高剂量组的血液学参数、血清铁蛋白、总铁结合能力和维生素 B12 都有所提高。值得注意的是,高剂量组(400 毫克/千克体重)与疾病对照组相比有显著改善(P<0.001)。值得注意的是,高剂量疗法使血液学参数恢复到基线水平,与标准药物(抗坏血酸亚铁)的疗效相同。这些实证研究结果凸显了辣木作为缓解氯化铝引起的贫血症的候选疗法的潜力。这些结果为今后的研究工作铺平了道路,以揭示驱动这些保护作用的确切机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Natural Remedies
Journal of Natural Remedies Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.40
自引率
0.00%
发文量
27
期刊介绍: Nature can provide all the remedies, for all. All substances produced by nature can be recognized; all cells talk the same language as we all are from the same mother cell. Journal of Natural Remedies is devoted toward the understandings of all remedies from nature. Journal of Natural Remedies publishes original articles related to utilisation of any natural source for remedy including bioactive natural products. Studies related to the resources, chemistry (including analytical), biological activity, biotechnology and pharmacology (including toxicology) of archaea, bacteria, protistas, fungi, plants, animals, viruses and minerals fall within the journal’s scope.
期刊最新文献
A Study on Biologically Active Components in Morinda citrifolia Leaf Extract and its Anti-cancer Effect by In Vitro Analysis and In Silico Molecular Docking Method Ayurveda as a Supportive Treatment: A Case Report on Integrative Management of Intracranial Haemorrhage Turmocin Plus Suppresses Vascular Endothelial Growth Factor (VEGF) and Macrophage Infiltration in the Management of Perineal Wounds, Anal Fistula, Acute Anal Fissures and Haemorrhoids Management of Kotha Roga (Necrotizing Fasciitis) by Modified Ksharapichu (Wound Packing): A Case Report Phytosomes: A Contemporary Method for Delivering Novel Herbal Drugs
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1