Revolutionizing diabetic wound healing: Targeted therapeutic strategies based on growth factors

Abstract

Wound healing in diabetic patients, particularly diabetic wound, poses a substantial challenge compared to typical wounds and can frequently worsen, potentially leading to amputation. Conventional treatments often fall short in effectively healing diabetic wounds and addressing their numerous complications. Growth factors are recognized as pivotal in orchestrating the intricate process of diabetic wound healing. Various growth factors, such as transforming growth factor beta 1, insulin-like growth factor, and vascular endothelial growth factor, assume distinct roles in this healing process. This suggests that therapeutic interventions capable of modulating multiple growth factors to align with the specific needs of wound healing could significantly enhance the treatment of diabetic wounds. Furthermore, some existing treatments have demonstrated the ability to facilitate the healing of diabetic wounds by influencing specific growth factors. The objective of this study was to investigate that the individual contributions of each growth factor in therapeutic strategies, with the aim of stimulating further innovative approaches to diabetes wound care.