Pub Date : 2026-01-12DOI: 10.1016/j.obmed.2026.100683
Andrej Belančić , Bojan Jelaković
{"title":"Beyond class effects: The need for agent-level stratification and hierarchical composite analysis in cardiovascular outcome trials","authors":"Andrej Belančić , Bojan Jelaković","doi":"10.1016/j.obmed.2026.100683","DOIUrl":"10.1016/j.obmed.2026.100683","url":null,"abstract":"","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"60 ","pages":"Article 100683"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.obmed.2025.100672
N. Pavithra , S. Ankul Singh , Rukaiah Fatma Begum , Krishna Undela , S. Nirenjen , B. Keerthana , Anuragh Singh , R. Mageswari , Sarvesh Sabarathinam
Epsilon (ε) cells represent the rarest endocrine population within the pancreatic islets but serve as the exclusive intra-islet source of ghrelin, a hormone increasingly recognized as a regulator of glucose homeostasis, β-cell function, and lipid metabolism. Once considered primarily an orexigenic signal, ghrelin is now understood to influence intra-islet crosstalk through direct β-cell inhibition and indirect somatostatin-mediated suppression of insulin secretion. Advances in single-cell and multi-omic technologies have refined the molecular identity of ε-cells, uncovering PDX1-low, NKX6.1-negative ghrelin-lineage signatures and non-coding RNA networks that stabilize their fate. ε-cell number and ghrelin output change dynamically across fetal development, adulthood, aging, and metabolic disease. In type 1 diabetes, ε-cell dysfunction occurs against a backdrop of autoimmune β-cell destruction, whereas in type 2 diabetes, impaired ghrelin signaling contributes directly to β-cell failure and metabolic deterioration. Obesity presents a paradox of suppressed circulating ghrelin yet preserved intra-islet activity, mediated partly by the LEAP2–GHSR1a axis. These insights highlight ε-cells as modulators of glucose and energy balance and identify ghrelin-axis interventions, including GHSR antagonists, GOAT inhibitors, and LEAP2 analogs, as emerging therapeutic strategies. This review synthesizes current knowledge on ε-cell biology, their context-dependent roles in diabetes and obesity, and future directions for targeting ε-cell pathways to improve metabolic health.
{"title":"The emerging role of epsilon cells in glucose homeostasis and lipostasis","authors":"N. Pavithra , S. Ankul Singh , Rukaiah Fatma Begum , Krishna Undela , S. Nirenjen , B. Keerthana , Anuragh Singh , R. Mageswari , Sarvesh Sabarathinam","doi":"10.1016/j.obmed.2025.100672","DOIUrl":"10.1016/j.obmed.2025.100672","url":null,"abstract":"<div><div>Epsilon (ε) cells represent the rarest endocrine population within the pancreatic islets but serve as the exclusive intra-islet source of ghrelin, a hormone increasingly recognized as a regulator of glucose homeostasis, β-cell function, and lipid metabolism. Once considered primarily an orexigenic signal, ghrelin is now understood to influence intra-islet crosstalk through direct β-cell inhibition and indirect somatostatin-mediated suppression of insulin secretion. Advances in single-cell and multi-omic technologies have refined the molecular identity of ε-cells, uncovering PDX1-low, NKX6.1-negative ghrelin-lineage signatures and non-coding RNA networks that stabilize their fate. ε-cell number and ghrelin output change dynamically across fetal development, adulthood, aging, and metabolic disease. In type 1 diabetes, ε-cell dysfunction occurs against a backdrop of autoimmune β-cell destruction, whereas in type 2 diabetes, impaired ghrelin signaling contributes directly to β-cell failure and metabolic deterioration. Obesity presents a paradox of suppressed circulating ghrelin yet preserved intra-islet activity, mediated partly by the LEAP2–GHSR1a axis. These insights highlight ε-cells as modulators of glucose and energy balance and identify ghrelin-axis interventions, including GHSR antagonists, GOAT inhibitors, and LEAP2 analogs, as emerging therapeutic strategies. This review synthesizes current knowledge on ε-cell biology, their context-dependent roles in diabetes and obesity, and future directions for targeting ε-cell pathways to improve metabolic health.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"59 ","pages":"Article 100672"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.obmed.2025.100680
Reem J. Al Argan , Safi G. Alqatari , Abrar J. Alwaheed , Manal A. Hasan , Shaya Y. AlQahtani , Mohammed D. Al Shubbar , Abdullah H. Alnasser , Safia M. Al Abbas , Noor H. AlYousef
<div><h3>Background</h3><div>Obesity is a global public health crisis, contributing to substantial morbidity and mortality due to its strong association with chronic diseases such as type 2 diabetes, cardiovascular disorders, and malignancies. Concurrently, vitamin D deficiency has become widespread, affecting nearly one billion people worldwide. Epidemiological studies consistently demonstrate an inverse relationship between obesity and vitamin D levels, with emerging hypotheses suggesting a bidirectional link.</div></div><div><h3>Objectives</h3><div>This review examines the association between obesity and vitamin D status, the underlying biological mechanisms, the role of vitamin D in metabolic disease, and the implications of vitamin D supplementation in obese populations.</div></div><div><h3>Results</h3><div>Epidemiological studies confirm that obese individuals exhibit significantly lower circulating 25-hydroxyvitamin D [25(OH)D] levels than their normal-weight counterparts. Mendelian randomization analyses further establish a causal link, indicating that obesity leads to vitamin D deficiency, rather than vice versa. Proposed biological mechanisms include volumetric dilution due to increased adipose tissue, sequestration of vitamin D in fat stores, and obesity-related impairments in vitamin D metabolism. Vitamin D plays a crucial role in metabolic health by influencing insulin secretion, lipid metabolism, and blood pressure regulation. Deficiency has been associated with insulin resistance, dyslipidemia, and overactivation of the renin-angiotensin-aldosterone system (RAAS), exacerbating obesity-related metabolic complications. However, while vitamin D supplementation effectively raises serum 25(OH)D levels, its impact on improving metabolic outcomes remains inconsistent across interventional studies. In addition, the joint impact of obesity and vitamin D deficiency on bone health remains unexplored, despite distinct mechanisms suggesting additive or synergistic harm. Targeted studies are needed to assess their combined effects using robust designs and comprehensive skeletal outcomes.</div></div><div><h3>Conclusions</h3><div>The strong inverse relationship between obesity and vitamin D status highlights the need for targeted interventions. While weight loss modestly improves vitamin D levels, BMI-adjusted vitamin D supplementation may be the most effective strategy for correcting deficiency in obese populations. Current guidelines suggest that obese individuals require higher doses of vitamin D to achieve optimal serum levels. However, further research is necessary to refine dosing strategies and determine the long-term impact of supplementation on metabolic health outcomes. Future investigations should integrate personalized supplementation approaches with lifestyle and pharmacological interventions to mitigate obesity-related metabolic disturbances effectively. Furthermore, obesity and vitamin D deficiency may jointly exacerbate skeletal de
{"title":"Vitamin D deficiency in obesity: Epidemiological evidence, biological mechanisms, and clinical considerations","authors":"Reem J. Al Argan , Safi G. Alqatari , Abrar J. Alwaheed , Manal A. Hasan , Shaya Y. AlQahtani , Mohammed D. Al Shubbar , Abdullah H. Alnasser , Safia M. Al Abbas , Noor H. AlYousef","doi":"10.1016/j.obmed.2025.100680","DOIUrl":"10.1016/j.obmed.2025.100680","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is a global public health crisis, contributing to substantial morbidity and mortality due to its strong association with chronic diseases such as type 2 diabetes, cardiovascular disorders, and malignancies. Concurrently, vitamin D deficiency has become widespread, affecting nearly one billion people worldwide. Epidemiological studies consistently demonstrate an inverse relationship between obesity and vitamin D levels, with emerging hypotheses suggesting a bidirectional link.</div></div><div><h3>Objectives</h3><div>This review examines the association between obesity and vitamin D status, the underlying biological mechanisms, the role of vitamin D in metabolic disease, and the implications of vitamin D supplementation in obese populations.</div></div><div><h3>Results</h3><div>Epidemiological studies confirm that obese individuals exhibit significantly lower circulating 25-hydroxyvitamin D [25(OH)D] levels than their normal-weight counterparts. Mendelian randomization analyses further establish a causal link, indicating that obesity leads to vitamin D deficiency, rather than vice versa. Proposed biological mechanisms include volumetric dilution due to increased adipose tissue, sequestration of vitamin D in fat stores, and obesity-related impairments in vitamin D metabolism. Vitamin D plays a crucial role in metabolic health by influencing insulin secretion, lipid metabolism, and blood pressure regulation. Deficiency has been associated with insulin resistance, dyslipidemia, and overactivation of the renin-angiotensin-aldosterone system (RAAS), exacerbating obesity-related metabolic complications. However, while vitamin D supplementation effectively raises serum 25(OH)D levels, its impact on improving metabolic outcomes remains inconsistent across interventional studies. In addition, the joint impact of obesity and vitamin D deficiency on bone health remains unexplored, despite distinct mechanisms suggesting additive or synergistic harm. Targeted studies are needed to assess their combined effects using robust designs and comprehensive skeletal outcomes.</div></div><div><h3>Conclusions</h3><div>The strong inverse relationship between obesity and vitamin D status highlights the need for targeted interventions. While weight loss modestly improves vitamin D levels, BMI-adjusted vitamin D supplementation may be the most effective strategy for correcting deficiency in obese populations. Current guidelines suggest that obese individuals require higher doses of vitamin D to achieve optimal serum levels. However, further research is necessary to refine dosing strategies and determine the long-term impact of supplementation on metabolic health outcomes. Future investigations should integrate personalized supplementation approaches with lifestyle and pharmacological interventions to mitigate obesity-related metabolic disturbances effectively. Furthermore, obesity and vitamin D deficiency may jointly exacerbate skeletal de","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"59 ","pages":"Article 100680"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.obmed.2025.100666
S. Arin Natania
I found the recent study by Alkhalfan et al. for identifying uric acid as a potential biomarker for lipedema and lymphedema through untargeted plasma metabolomics. To further enhance the clinical translation of these findings, I, propose a structured framework comprising baseline control characterization, longitudinal uric acid profiling across treatment phases, multi-analyte biomarker integration, and endocrine-based stratification. This approach aims to improve diagnostic specificity, accommodate inter-individual variability, and establish uric acid as a reliable tool in differentiating and monitoring lymphatic disorders.
{"title":"Letter to the editor regarding the article “Exploring uric acid as a biomarker in lipedema and lymphedema: A metabolomics study with prospective validation”","authors":"S. Arin Natania","doi":"10.1016/j.obmed.2025.100666","DOIUrl":"10.1016/j.obmed.2025.100666","url":null,"abstract":"<div><div>I found the recent study by Alkhalfan et al. for identifying uric acid as a potential biomarker for lipedema and lymphedema through untargeted plasma metabolomics. To further enhance the clinical translation of these findings, I, propose a structured framework comprising baseline control characterization, longitudinal uric acid profiling across treatment phases, multi-analyte biomarker integration, and endocrine-based stratification. This approach aims to improve diagnostic specificity, accommodate inter-individual variability, and establish uric acid as a reliable tool in differentiating and monitoring lymphatic disorders.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"59 ","pages":"Article 100666"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.obmed.2025.100681
Elaine Chiquette , Louise Thisted , Michael Feigh , Stephen Daly , James Besser , David G. Maggs
Subcutaneous pump delivery of the GLP1-receptor-agonist exenatide reduced body weight and improved glycemia in the DIO mouse. Basal-bolus administration conferred advantage over basal alone. This mode of incretin-based therapy offers an alternative to conventional intermittent dosing and further examination of this approach is warranted.
{"title":"Elucidating the potential benefit of pump-delivered subcutaneous GLP-1R agonist: an exploratory study in the diet-induced obese mouse","authors":"Elaine Chiquette , Louise Thisted , Michael Feigh , Stephen Daly , James Besser , David G. Maggs","doi":"10.1016/j.obmed.2025.100681","DOIUrl":"10.1016/j.obmed.2025.100681","url":null,"abstract":"<div><div>Subcutaneous pump delivery of the GLP1-receptor-agonist exenatide reduced body weight and improved glycemia in the DIO mouse. Basal-bolus administration conferred advantage over basal alone. This mode of incretin-based therapy offers an alternative to conventional intermittent dosing and further examination of this approach is warranted.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"59 ","pages":"Article 100681"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.obmed.2025.100679
Tatiana Sampaio , Samuel Encarnação , Bruna Amaro , Joana Ribeiro , Luís Branquinho , António M. Monteiro , José E. Teixeira , Soukaina Hattabi , Andrew Sortwell , Luciano Bernardes Leite , Alexandra Malheiro , Pedro Rodrigues , Beat Knechtle , Pedro Flores , Pedro Forte
The escalating prevalence of obesity among adolescents has emerged as a critical global public health challenge. Machine learning techniques have been used to predict obesity in adolescents. This study aimed to develop and validate a robust obesity prediction model for adolescents using this hybrid approach, leveraging data from a diverse cross-sectional population-based study. The hybrid method combines statistical inference with non-linear machine learning to enhance prediction accuracy. Physical fitness data were collected from the FITescola® tests. Multiple tests were employed to evaluate physical fitness. Multiple Poisson's multiple regression method was applied to identify the most predictive variables set of the adolescent's body mass index (BMI) classification. The model's goodness-of-fit statistics indicate a strong fit, with a log-likelihood of −8068.6 and a Pseudo R-squared value of 0.8853, where the aerobic fitness (AF), upper limb strength (ULS) and lower limb flexibility (LLF) presented an inverse association with the adolescent's BMI. In contrast the adolescent's core strength presented a positive association with their body mass. The random forest regression showed that an average of 35 repetition on the yo-yo test predicted a healthy BMI percentile [predBMIperc = 0.31]. In addition, the model presented good validity [MAE = 0.36, MSE = 0.20, RMSE = 0.45, R2 = 0.54]. The model's strong fit and accurate random forest regression's predictions suggest that physical fitness components, such as aerobic fitness, upper limb strength, lower limb power, and core strength, play a significant role in obesity risk among adolescents.
{"title":"Machine learning prediction of adolescent obesity using physical fitness data","authors":"Tatiana Sampaio , Samuel Encarnação , Bruna Amaro , Joana Ribeiro , Luís Branquinho , António M. Monteiro , José E. Teixeira , Soukaina Hattabi , Andrew Sortwell , Luciano Bernardes Leite , Alexandra Malheiro , Pedro Rodrigues , Beat Knechtle , Pedro Flores , Pedro Forte","doi":"10.1016/j.obmed.2025.100679","DOIUrl":"10.1016/j.obmed.2025.100679","url":null,"abstract":"<div><div>The escalating prevalence of obesity among adolescents has emerged as a critical global public health challenge. Machine learning techniques have been used to predict obesity in adolescents. This study aimed to develop and validate a robust obesity prediction model for adolescents using this hybrid approach, leveraging data from a diverse cross-sectional population-based study. The hybrid method combines statistical inference with non-linear machine learning to enhance prediction accuracy. Physical fitness data were collected from the FITescola® tests. Multiple tests were employed to evaluate physical fitness. Multiple Poisson's multiple regression method was applied to identify the most predictive variables set of the adolescent's body mass index (BMI) classification. The model's goodness-of-fit statistics indicate a strong fit, with a log-likelihood of −8068.6 and a Pseudo R-squared value of 0.8853, where the aerobic fitness (AF), upper limb strength (ULS) and lower limb flexibility (LLF) presented an inverse association with the adolescent's BMI. In contrast the adolescent's core strength presented a positive association with their body mass. The random forest regression showed that an average of 35 repetition on the yo-yo test predicted a healthy BMI percentile [predBMIperc = 0.31]. In addition, the model presented good validity [MAE = 0.36, MSE = 0.20, RMSE = 0.45, R2 = 0.54]. The model's strong fit and accurate random forest regression's predictions suggest that physical fitness components, such as aerobic fitness, upper limb strength, lower limb power, and core strength, play a significant role in obesity risk among adolescents.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"59 ","pages":"Article 100679"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetic foot ulcers (DFUs) are one of the serious complications of diabetes mellitus, contributing to lower limb amputations and leading to decreased quality of life (QoL). Despite many advancements in the pathological approach of DFU, including neuropathy, ischemia, infection, and impaired wound healing, translating scientific breakthroughs into a clinical setup is still a major challenge. This review highlights current advancements in DFU management by bridging the gap between scientific innovations and clinical applications. It focuses on the role of emerging therapies, such as stem cell therapies, 3D bioprinting, and nanotechnology applications. 3D printing customised wound coverings, such as Manipulated Autologous Extracellular Matrix (MA-ECM), demonstrated accelerated wound recovery compared to standard of care. In addition, the review highlights integrative approaches such as negative-pressure wound therapy, hyperbaric oxygen therapy, and diagnostic advancements enabled by artificial intelligence tools. The review explores the antimicrobial and biofilm targeting by using silver nanoparticles, bacteriophages, and photodynamic and blue light therapies. The review further describes the role of AI and ML in wound assessment, and the role of biophysical and electro-magnetic therapies in management.
{"title":"Therapeutic Frontiers in diabetic foot ulcers: Bridging science and clinical practice","authors":"Palwinder Kaur , Amani Gilbert Mfinanga , Vancha Harish , Sharfuddin Mohd , J.P. Yanadaiah , Palakurthi Yanadaiah , Krishnaveni Manubolu","doi":"10.1016/j.obmed.2025.100678","DOIUrl":"10.1016/j.obmed.2025.100678","url":null,"abstract":"<div><div>Diabetic foot ulcers (DFUs) are one of the serious complications of diabetes mellitus, contributing to lower limb amputations and leading to decreased quality of life (QoL). Despite many advancements in the pathological approach of DFU, including neuropathy, ischemia, infection, and impaired wound healing, translating scientific breakthroughs into a clinical setup is still a major challenge. This review highlights current advancements in DFU management by bridging the gap between scientific innovations and clinical applications. It focuses on the role of emerging therapies, such as stem cell therapies, 3D bioprinting, and nanotechnology applications. 3D printing customised wound coverings, such as Manipulated Autologous Extracellular Matrix (MA-ECM), demonstrated accelerated wound recovery compared to standard of care. In addition, the review highlights integrative approaches such as negative-pressure wound therapy, hyperbaric oxygen therapy, and diagnostic advancements enabled by artificial intelligence tools. The review explores the antimicrobial and biofilm targeting by using silver nanoparticles, bacteriophages, and photodynamic and blue light therapies. The review further describes the role of AI and ML in wound assessment, and the role of biophysical and electro-magnetic therapies in management.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"59 ","pages":"Article 100678"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.obmed.2025.100676
Sanja Lepić , Sonja Marjanović
Objective
Healthcare personnel are pivotal in promoting healthy lifestyles, including balanced nutrition. This study compares nutritional knowledge and its relationship with anthropometric measures between healthcare and non-healthcare personnel at a tertiary healthcare facility.
Methods
A cross-sectional study of 200 participants (100 healthcare, 100 non-healthcare personnel; equal gender distribution) used questionnaires to assess nutritional knowledge across four domains and measured anthropometric indices (BMI, PBF). Statistical analyses included t-tests, chi-square tests, and ANOVA.
Results
Healthcare personnel demonstrated significantly better nutritional knowledge (p < 0.01) and health awareness (p < 0.05) than non-healthcare personnel. Females scored higher in dietary habits (p = 0.03) and health awareness (p = 0.04). While no direct correlation between total nutrition scores and BMI/PBF was found, higher physical activity scores were linked to healthier anthropometric measures (p < 0.05).
Conclusions
Enhanced nutritional knowledge among healthcare personnel, particularly women, may influence healthier body composition. This study highlights the need to address nutritional knowledge gaps and promote healthier lifestyles. Further research should explore targeted interventions for knowledge application in obesity prevention.
{"title":"Nutritional knowledge and obesity in healthcare vs. non-healthcare hospital personnel","authors":"Sanja Lepić , Sonja Marjanović","doi":"10.1016/j.obmed.2025.100676","DOIUrl":"10.1016/j.obmed.2025.100676","url":null,"abstract":"<div><h3>Objective</h3><div>Healthcare personnel are pivotal in promoting healthy lifestyles, including balanced nutrition. This study compares nutritional knowledge and its relationship with anthropometric measures between healthcare and non-healthcare personnel at a tertiary healthcare facility.</div></div><div><h3>Methods</h3><div>A cross-sectional study of 200 participants (100 healthcare, 100 non-healthcare personnel; equal gender distribution) used questionnaires to assess nutritional knowledge across four domains and measured anthropometric indices (BMI, PBF). Statistical analyses included t-tests, chi-square tests, and ANOVA.</div></div><div><h3>Results</h3><div>Healthcare personnel demonstrated significantly better nutritional knowledge (p < 0.01) and health awareness (p < 0.05) than non-healthcare personnel. Females scored higher in dietary habits (p = 0.03) and health awareness (p = 0.04). While no direct correlation between total nutrition scores and BMI/PBF was found, higher physical activity scores were linked to healthier anthropometric measures (p < 0.05).</div></div><div><h3>Conclusions</h3><div>Enhanced nutritional knowledge among healthcare personnel, particularly women, may influence healthier body composition. This study highlights the need to address nutritional knowledge gaps and promote healthier lifestyles. Further research should explore targeted interventions for knowledge application in obesity prevention.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"59 ","pages":"Article 100676"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimizing post-bariatric surgery weight management: The role of semaglutide","authors":"Tannaz Jamialahmadi , Wael Almahmeed , Salim S. Virani , Amirhossein Sahebkar","doi":"10.1016/j.obmed.2025.100675","DOIUrl":"10.1016/j.obmed.2025.100675","url":null,"abstract":"","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"59 ","pages":"Article 100675"},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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