O. Katkhanova, Galina Nikolaevna Burtseva, Anastasia Vadimovna Solovyova
{"title":"POSSIBILITIES OF USING TOPICAL RETINOIDS AND AZELAIC ACID IN ACNE THERAPY","authors":"O. Katkhanova, Galina Nikolaevna Burtseva, Anastasia Vadimovna Solovyova","doi":"10.25208/vdv11661","DOIUrl":null,"url":null,"abstract":"Background. \nAcne therapy is an urgent problem of dermatocosmetology. The clinical manifestations of dermatosis can be alleviated, and its long-term consequences can be prevented by early diagnosis and timely treatment, which affects all parts of the pathogenesis in a multifaceted way. \nThe aim of the study was to compare the clinical efficacy and safety of the use of monotherapy of 0.1% adapalene cream (Adaklin) with combined external therapy of 0.1% adapalene cream (Adaklin) with 20% azelaic acid cream (Azix-Derm) in the treatment of mild to moderate acne. \nMethods. 50 patients aged 12 to 50 years with mild to moderate acne were under observation. Patients group 1 of observation (n = 16), were prescribed Adaklin cream, 1 time per day (evening) against the background of skin care. In the group 2 with mild to moderate papulo-pustular acne and post-inflammatory changes, patients were prescribed a combination of 0.1% adapalene cream and 20% azelaic acid cream \nResults. Total clinical remission after 6 months therapy was achieved in 70% of cases, a significant improvement in 28%.In group 1 clinical recovery was obtained in 48% of patients, a significant improvement in 50%, in patients from the group 2 clinical recovery was recorded in 58%, significant improvement in 36%; Combined treatment was able to achieve regression of dyschromia in 46% of patients, pseudoatorofy in 22%, which significantly improved the results of therapy and made it possible to achieve a good cosmetic effect. Conclusion. The combined use of drugs for external use of adapalene and AK in the treatment of papulo-pustular acne of mild and AK in the treatment of papulo-pustular acne of mild and moderate severity can significantly increase the effectiveness of treatment, achieve a stable clinical effect and remission of the disease, as well as improve the quality of life of patients.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"172 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vestnik dermatologii i venerologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25208/vdv11661","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background.
Acne therapy is an urgent problem of dermatocosmetology. The clinical manifestations of dermatosis can be alleviated, and its long-term consequences can be prevented by early diagnosis and timely treatment, which affects all parts of the pathogenesis in a multifaceted way.
The aim of the study was to compare the clinical efficacy and safety of the use of monotherapy of 0.1% adapalene cream (Adaklin) with combined external therapy of 0.1% adapalene cream (Adaklin) with 20% azelaic acid cream (Azix-Derm) in the treatment of mild to moderate acne.
Methods. 50 patients aged 12 to 50 years with mild to moderate acne were under observation. Patients group 1 of observation (n = 16), were prescribed Adaklin cream, 1 time per day (evening) against the background of skin care. In the group 2 with mild to moderate papulo-pustular acne and post-inflammatory changes, patients were prescribed a combination of 0.1% adapalene cream and 20% azelaic acid cream
Results. Total clinical remission after 6 months therapy was achieved in 70% of cases, a significant improvement in 28%.In group 1 clinical recovery was obtained in 48% of patients, a significant improvement in 50%, in patients from the group 2 clinical recovery was recorded in 58%, significant improvement in 36%; Combined treatment was able to achieve regression of dyschromia in 46% of patients, pseudoatorofy in 22%, which significantly improved the results of therapy and made it possible to achieve a good cosmetic effect. Conclusion. The combined use of drugs for external use of adapalene and AK in the treatment of papulo-pustular acne of mild and AK in the treatment of papulo-pustular acne of mild and moderate severity can significantly increase the effectiveness of treatment, achieve a stable clinical effect and remission of the disease, as well as improve the quality of life of patients.